Publications by authors named "Z Al Deesi"
Article Synopsis
- A study was conducted to analyze the clinical and genetic features of Middle Eastern patients with Multisystem Inflammatory Syndrome in Children (MIS-C), focusing on those of Arab and Asian descent.
- Involving 45 MIS-C patients and 25 healthy controls, researchers used whole exome sequencing to identify genetic variants and correlate them to the symptoms and severity of the illness.
- Findings revealed significant dysregulation of inflammatory markers in MIS-C patients, with common symptoms including mucocutaneous and gastrointestinal issues, cardiac complications, and rare genetic variants found in immune-related genes.
We describe the protocol for identifying COVID-19 severity specific cell types and their regulatory marker genes using single-cell transcriptomics data. We construct COVID-19 comorbid disease-associated gene list using multiple databases and literature resources. Next, we identify specific cell type where comorbid genes are upregulated.
View Article and Find Full Text PDFUnderstanding host cell heterogeneity is critical for unraveling disease mechanism. Utilizing large-scale single-cell transcriptomics, we analyzed multiple tissue specimens from patients with life-threatening COVID-19 pneumonia, compared with healthy controls. We identified a subtype of monocyte-derived alveolar macrophages (MoAMs) where genes associated with severe COVID-19 comorbidities are significantly upregulated in bronchoalveolar lavage fluid of critical cases.
View Article and Find Full Text PDFBackground: Gram-negative organisms harbouring carbapenem resistance genes (CRGs) are spreading globally, including in Gulf Cooperation Council (GCC) countries. However, relatively few data are available about carriage of CRGs in hospitalized patients in this region.
Aim: To determine prevalence of CRG carriage and risk factors for colonization among patients in GCC hospitals.
Saliva for molecular detection of SARS-CoV-2 in school-age children.
Clin Microbiol Infect
September 2021
Objectives: The high diagnostic accuracy indices for saliva severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcriptase PCR (RT-PCR) reported in adults has not been demonstrated in children, and adequately powered studies focused on the paediatric population are lacking. This study was carried out to determine the diagnostic accuracy of saliva for SARS-CoV-2 RT-PCR in ambulatory children.
Methods: During 1 to 23 October 2020, we recruited a population-based sample of children presenting for coronavirus disease 2019 (COVID-19) screening in Dubai, United Arab Emirates.