Publications by authors named "Z A Lone"
Objectives: To assess whether the effect of sarcopenia on neoadjuvant chemotherapy (NAC) toxicity is modified by borderline renal function (estimated glomerular filtration rate [eGFR] 40-65 mL/min) and whether sarcopenia and borderline renal function are independently associated with NAC toxicity risk.
Patients And Methods: All patients with muscle-invasive bladder cancer (MIBC) who underwent radical cystectomy (RC) between 2010 and 2022, with available cross-sectional imaging prior to NAC initiation, were included. Skeletal mass was measured from axial computed tomography images obtained at the level of the L3 vertebral body, using Aquarius Intuition software.
Article Synopsis
- The study investigates the effects of prolonged ischaemia during partial nephrectomy (PN) on kidney function, highlighting a lack of research in this area despite its clinical importance.
- Among 1371 patients, the analysis focused on 759 who had assessments on kidney function pre- and post-surgery, looking at recovery rates related to ischaemia type and duration.
- Findings revealed that while warm ischaemia showed a significant negative impact on kidney recovery after 30 minutes, cold ischaemia maintained higher recovery rates, suggesting the need to limit warm ischaemia duration for better patient outcomes.
Article Synopsis
- Micropapillary variant urothelial carcinoma (MPUC) is linked to higher treatment failure risks and occult lymph node metastasis, impacting outcomes after radical cystectomy (RC).
- The study evaluated 67 patients with MPUC to see how the percentage of MPUC in tissue samples affects lymph node positivity and patient survival following treatment.
- Results indicated that a higher percentage of MPUC (≥30%) and advanced clinical stage (≥T2) were significant predictors of lymph node metastasis at RC, with patients having cT1 disease showing the lowest metastasis rates.
Purpose: To study the pathologic and short-term oncological and survival outcomes following Transvesical Single-Port Robot-Assisted Radical Prostatectomy.
Materials And Methods: A retrospective review was performed on prospectively collected data on 169 patients with low and intermediate-risks prostate cancer, who either underwent Single-Port Transvesical or Multi-Port Transperitoneal Radical Prostatectomy by a single surgeon between 2015 and 2022. Preoperative clinicopathologic characteristics, as well as final histopathology outcomes, were compared.