[The influence of amylin on the bile acid spectrum in rats].

In acute experiments on the rats with cannulated common biliary duct, the influence ofamylin on the level of bile secretion and bile acids spectrum was investigated. It was shown that subcutaneous administration of amylin at the dose 1 mg/kg body weight doesn't affect the volume of secreted bile. Under these conditions, the concentration of taurocholic acid was increased and the concentration of tauroconjugates of chenodeoxycholic and deoxycholic acids was decreased in the bile.

[The influence of calcitonin on the liver secretory function in rats].

The influence of calcitonin on the choleresis level and bile acids spectrum was investigated in acute experiments on the rats with common biliary duct cannulated. We determined the intensity of bile secretion during 3 hours and quantitative content of conjugated and free bile acids using thin-layer chromatography. It was shown that intramuscular introduction of synthetic salmon calcitonin (200 ng/kg) increases the secreted bile volume and the content of conjugated bile acids in the bile.

[The effect of desmopressin on changes of bile acids specter in rats].

We studied the effect of the synthetic analogue of antidiuretic hormone-desmopressin on the level of choleresis and the bile acids spectrum in acute experiments in bile duct-cannulated rats. It is shown that desmopressin increases bile flow and concentration of taurin-conjugated bile acids. In this situation, the concentration ofglycocholates practically is not changed, and concentration of free bile acids is diminished, which results in increase in the conjugation coefficient.