Publications by authors named "Z A Cole"
Background: Proton pump inhibitors (PPIs) are often prescribed to manage corticosteroid-induced gastrointestinal toxicity during glioblastoma (GBM) treatment, but were recently identified as strong inducers of aldehyde dehydrogenase-1A1 (ALDH1A1). ALDH1A1 is a primary metabolic enzyme impacting the outcome of chemotherapy, including temozolomide. High expression of ALDH1A1 is associated with poor prognosis in multiple cancers, suggesting PPIs may have a negative impact on survival.
View Article and Find Full Text PDFArticle Synopsis
- Patient Initiated Follow-Up (PIFU) is being adopted in the NHS to improve outpatient care by enabling patients to manage their follow-ups, especially in high-demand areas like rheumatology.
- PIFU has shown similar safety and results compared to traditional methods, while enhancing personalized care and efficiency, potentially reducing patient backlogs.
- Successful implementation requires careful patient selection, education for both patients and staff, clear operational guidelines, and effective use of digital tools like ePROMs for patient monitoring.
Grade IV glioma, formerly known as glioblastoma multiforme (GBM) is the most aggressive and lethal type of brain tumor, and its treatment remains challenging in part due to extensive interpatient heterogeneity in disease driving mechanisms and lack of prognostic and predictive biomarkers. Using mechanistic inference of node-edge relationship (MINER), we have analyzed multiomics profiles from 516 patients and constructed an atlas of causal and mechanistic drivers of interpatient heterogeneity in GBM (gbmMINER). The atlas has delineated how 30 driver mutations act in a combinatorial scheme to causally influence a network of regulators (306 transcription factors and 73 miRNAs) of 179 transcriptional "programs", influencing disease progression in patients across 23 disease states.
View Article and Find Full Text PDFPurpose: There is an increasing focus on using motion in augmentative and alternative communication (AAC) systems. In considering brain-computer interface access to AAC (BCI-AAC), motion may provide a simpler or more intuitive avenue for BCI-AAC control. Different motion techniques may be utilized in supporting competency with AAC devices including simple (e.
View Article and Find Full Text PDFObjective: To evaluate the safety of repeated applications of permethrin concentrations (0% control, 1.5%, 5%, and 10%) to the necks and faces of horses and assess the efficacy and longevity of permethrin as an equine tick repellent.
Animals: 5 healthy adult Quarter Horses.