The NLR family pyrin domain-containing 11 protein contributes to the regulation of inflammatory signaling.

Mammalian Nod-like receptor (NLR) proteins contribute to the regulation and induction of innate and adaptive immunity in mammals, although the function of about half of the currently identified NLR proteins remains poorly characterized. Here we analyzed the function of the primate-specific gene product. We show that is highly expressed in immune cells, including myeloid cells, B cells, and some B cell lymphoma lines.