Publications by authors named "Yvonne D Rollins"
Objectives: To characterize the prevalence of cognitive and behavioral symptoms using a cognitive/behavioral screening battery in a large prospective multicenter study of amyotrophic lateral sclerosis (ALS).
Methods: Two hundred seventy-four patients with ALS completed 2 validated cognitive screening tests and 2 validated behavioral interviews with accompanying caregivers. We examined the associations between cognitive and behavioral performance, demographic and clinical data, and C9orf72 mutation data.
ALS Multicenter Cohort Study of Oxidative Stress (ALS COSMOS): study methodology, recruitment, and baseline demographic and disease characteristics.
Amyotroph Lateral Scler Frontotemporal Degener
June 2014
Abstract In a multicenter study of newly diagnosed ALS patients without a reported family history of ALS, we are prospectively investigating whether markers of oxidative stress (OS) are associated with disease progression. Methods utilize an extensive structured telephone interview ascertaining environmental, lifestyle, dietary and psychological risk factors associated with OS. Detailed assessments were performed at baseline and at 3-6 month intervals during the ensuing 30 months.
View Article and Find Full Text PDFUp to 50% of persons with amyotrophic lateral sclerosis (ALS) develop cognitive impairments, particularly of executive function (EF). The Frontal Assessment Battery (FAB) provides a method for rapid assessment of EF. We investigated the FAB as an assessment of cognitive impairment among 16 subjects with ALS, and evaluated their performance on the FAB and the Mini-Mental State Examination (MMSE).
View Article and Find Full Text PDFArticle Synopsis
- Morvan's syndrome is linked to peripheral nervous system issues and often features voltage-gated potassium channel antibodies.
- A case study showcased a 64-year-old man with this syndrome experiencing reduplicative paramnesia (RP) alongside traditional symptoms.
- Treatment with immunotherapy improved his RP and myoclonus, suggesting that RP can occur with Morvan's syndrome and may respond to similar treatments.
Article Synopsis
- The study aims to investigate the genetics behind very early onset Alzheimer's disease (VEOAD), which occurs before the age of 35.
- The researchers analyzed a case of a man with symptoms resembling frontotemporal dementia but who was diagnosed with Alzheimer's disease at autopsy; histological and genetic assessments were conducted.
- The findings indicate that most VEOAD cases are linked to PSEN1 mutations, emphasizing the importance of genetic testing for individuals under 35 with dementia for accurate diagnosis and family counseling.