Publications by authors named "Yvonne Buttle"
Article Synopsis
- - Neonatal encephalopathy (NE) leads to multiorgan injury in newborns, with therapeutic hypothermia being the common treatment; this study aims to identify effective scoring systems for assessing organ dysfunction in NE.
- - A systematic review of 628 articles was conducted, identifying 12 relevant studies, which showed a correlation between the severity of NE and multiorgan dysfunction, but highlighted significant differences across scoring systems used.
- - For a comprehensive scoring system, the study suggests including assessments of various organ systems (renal, hepatic, respiratory, neurological, hematological, and cardiovascular), while noting that further validation and standardization are necessary for effective use, especially considering the impact of therapeutic hypothermia.
Many studies show the importance of biological sex for the onset, progression, and response to treatment in brain disorders. In line with these reports, health agencies have requested that all trials, both at the clinical and preclinical level, use a similar number of male and female subjects to correctly interpret the results. Despite these guidelines, many studies still tend to be unbalanced in the use of male and female subjects.
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