Publications by authors named "Yvette Unoarumhi"
Group A streptococcal strains potentially acquire new M protein gene types through genetic recombination (emm switching). To detect such variants, we screened 12,596 invasive GAS genomes for strains of differing emm types that shared the same multilocus sequence type (ST). Through this screening we detected a variant consisting of 16 serum opacity factor (SOF)-positive, emm pattern E, emm82 isolates that were ST36, previously only associated with SOF-negative, emm pattern A, emm12.
View Article and Find Full Text PDFThis report describes genome sequences for nine Listeria innocua strains that varied in hemolytic phenotypes on sheep blood agar. All strains were sequenced using Pacific Biosciences (PacBio) single-molecule real-time (SMRT) chemistry; overall, the average read length of these sequences was 2,869,880 bp, with an average GC content of 37%.
View Article and Find Full Text PDFComplete Genome Sequences of Four Macrolide-Resistant Nondiphtheritic Isolates.
Microbiol Resour Announc
September 2022
This report describes the complete genome sequences of four isolates of the nondiphtheritic (NDC) species Corynebacterium pseudodiphtheriticum and Corynebacterium propinquum, recovered during investigation of a large diphtheria outbreak in Bangladesh. These data will assist in better delineating the boundary between these related species and understanding their virulence potential.
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- Genomic surveillance is essential for monitoring emerging SARS-CoV-2 variants, which can impact public health by affecting transmissibility and immune response.
- Between June 2021 and January 2022, the CDC enhanced its data collection methods to provide more accurate estimates of variant proportions by utilizing public repositories and refining analysis techniques.
- During this time, the Delta variant initially dominated infections but was quickly supplanted by the Omicron variant, which accounted for nearly all U.S. cases by January 2022, highlighting the need for ongoing surveillance in pandemic response.
PacBio and Illumina MiSeq platforms were used for genomic sequencing of a strain isolated from a patient infected in Pakistan. PacBio assemblies were generated using Flye v2.4 and polished with MiSeq data.
View Article and Find Full Text PDFWe investigated an autochthonous case of cutaneous leishmaniasis caused by a genetically different Leishmania sp. in a patient in Arizona, USA. This parasite was classified into the subgenus Leishmania on the basis of multilocus DNA sequence and phylogenetic analyses of the rRNA locus and 11 reference genes.
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- Whooping cough, primarily caused by Bordetella pertussis, has seen a resurgence in the U.S., highlighting the need to study the chromosome structural fluidity of its strains, which involves rearrangement and deletion.
- Researchers analyzed complete genome sequences from 167 species isolates and 469 other isolates to understand the patterns of chromosome rearrangement among related pathogens in the Bordetella genus.
- The study found that large inversions in gene order are mainly observed in species with multiple insertion sequence (IS) elements, indicating that while some species show less chromosomal diversity, they still experience similar mutations in gene order.
Background: Bacterial global regulators each regulate the expression of several hundred genes. In Escherichia coli, the top seven global regulators together control over half of all genes. Leucine-responsive regulatory protein (Lrp) is one of these top seven global regulators.
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