Early diagnosis of acute myocardial infarction in patients with mild elevations of cardiac troponin.

Background: The early diagnosis of acute myocardial infarction (AMI) in patients with mild elevations of high-sensitivity cardiac troponin (hs-cTn) is a challenge. It is unclear whether copeptin, a marker of endogenous stress, or 1h-hs-cTn changes are better suited to address this important unmet clinical need.

Methods: We prospectively enrolled patients presenting with symptoms suggestive of AMI to the emergency department (ED).