Practical application of good participatory practices for trials of emerging pathogens: Developing materials for use in ACTIV-3, -3b, and ACTIV-associated COVID-19 trials.

The emergence of the COVID-19 pandemic required an immediate global clinical research response. The ACTIV (Accelerating COVID-19 Therapeutic Interventions and Vaccines)-3 trials and the ACTIV-associated Outpatient Treatment with Anti-Coronavirus Immunoglobulin trial used Good Participatory Practices (GPP) to develop materials for study implementation from a global network perspective. GPP guidelines offer a framework for engaging stakeholders throughout the research process.

ACTIV trials: cross-trial lessons learned for master protocol implementation.

The United States Government (USG) public-private partnership "Accelerating COVID-19 Treatment Interventions and Vaccines" (ACTIV) was launched to identify safe, effective therapeutics to treat patients with Coronavirus Disease 2019 (COVID-19) and prevent hospitalization, progression of disease, and death. Eleven original master protocols were developed by ACTIV, and thirty-seven therapeutic agents entered evaluation for treatment benefit. Challenges encountered during trial implementation led to innovations enabling initiation and enrollment of over 26,000 participants in the trials.

Forging a sustainable response to HIV/AIDS in the Caribbean--the strategic role of a regional conference.

The paper provides a rationale for a Caribbean HIV/AIDS Conference as a key ingredient to the regional response mechanism. This initiative stems from the need to address crucial elements of the regional response within the realities of the present regional economic situation and global financial climate, as well as epidemiological and demographic trends. A mixed method approach was adopted for this study, drawing on both primary and secondary data collection techniques.

Health priorities in developing countries.

In essence then, the health sector in developing countries is weak and fragile; it is vulnerable to external financial pressures and the vagaries of national budget priorities. Throughout the world, leaders in health must seek more effective ways of impressing upon others who make national policy the long term consequences of crises which disrupt health services. Above all, the impact of disinvestment in health in creating underdevelopment and the value of investment in health in creating development must be demonstrably established.