Cohort profile: the CARTaGENE Cohort Nutrition Study (Quebec, Canada).

Purpose: To address emerging nutritional epidemiological research questions, data from contemporary cohorts are needed. CARTaGENE is the largest ongoing prospective cohort study of men and women in Québec, Canada. Dietary information was collected making it a rich resource for the exploration of diet in the aetiology of many health outcomes.

Five-year absolute risk estimates of colorectal cancer based on CCRAT model and polygenic risk scores: A validation study using the Quebec population-based cohort CARTaGENE.

The objective was to evaluate the predictive performance of the Colorectal Cancer Risk Assessment Tool (CCRAT) and three polygenic risk scores (Hsu et al., 2015; Law et al., 2019, Archambault et al.

Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses.

Objectives: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer.

Methods: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology.

Epidemiological characteristics of the COVID-19 spring outbreak in Quebec, Canada: a population-based study.

Background: By mid-July 2020, more than 108,000 COVID-19 cases had been diagnosed in Canada with more than half in the province of Quebec. In this context, we launched a study to analyze the epidemiological characteristics and the socio-economic impact of the spring outbreak in the population.

Method: We conducted an online survey of the participants of the CARTaGENE population-based cohort, composed of middle-aged and older adults.

Validation of breast cancer risk assessment tools on a French-Canadian population-based cohort.

Objectives: Evaluate the accuracy of the Breast Cancer Risk Assessment Tool (BCRAT), International Breast Cancer Intervention Study risk evaluation tool (IBIS), Polygenic Risk Scores (PRS) and combined scores (BCRAT+PRS and IBIS +PRS) to predict the occurrence of invasive breast cancers at 5 years in a French-Canadian population.

Design: Population-based cohort study.

Setting: We used the population-based cohort CARTaGENE, composed of 43 037 Quebec residents aged between 40 and 69 years and broadly representative of the population recorded on the Quebec administrative health insurance registries.

Agreement in the CARTaGENE cohort between self-reported medication use and claim data.

Objectives: To describe the agreement of self-reported medication use with claim prescription records and to ascertain factors associated with agreement between the two data sources.

Methods: Baseline data on self-reported medication use was extracted from CARTaGENE, a cohort study in Quebec, Canada, and from the provincial health insurance records (dispensation database) of the same individuals. Kappa statistics were used to estimate concordance beyond chance between the two data sources.

Quantifying the Predictive Accuracy of a Polygenic Risk Score for Predicting Incident Cancer Cases : Application to the CARTaGENE Cohort.

With the increasing use of polygenic risk scores (PRS) there is a need for adapted methods to evaluate the predictivity of these tools. In this work, we propose a new pseudo- criterion to evaluate PRS predictive accuracy for time-to-event data. This new criterion is related to the score statistic derived under a two-component mixture model.

Green space associations with mental health and cognitive function: Results from the Quebec CARTaGENE cohort.

Unlabelled: Urban green space may be important to mental health, but the association between long-term green space exposures and depression, anxiety, and cognitive function in adults remains unknown.

Methods: We examined 8,144 adults enrolled in the CARTaGENE cohort in Quebec Canada. Average green space and change in green space with residential mobility were assessed using satellite-derived normalized difference vegetation index from 5-year residential address histories.

Cohort profile of the CARTaGENE study: Quebec's population-based biobank for public health and personalized genomics.

The CARTaGENE (CaG) study is both a population-based biobank and the largest ongoing prospective health study of men and women in Quebec. In population-based cohorts, participants are not recruited for a particular disease but represent a random selection among the population, minimizing the need to correct for bias in measured phenotypes. CaG targeted the segment of the population that is most at risk of developing chronic disorders, that is 40-69 years of age, from four metropolitan areas in Quebec.

Use and reimbursement costs of smoking cessation medication under the Quebec public drug insurance plan.

Objectives: Since October 2000, the nicotine patch, nicotine gum and bupropion have been reimbursed under Quebec's public drug insurance plan. The objective of this study is to describe use of these medications between October 2000 and December 2004 by smokers covered by the public plan, as well as the costs of reimbursing these medications.

Methods: Data from the Régie de l'assurance maladie du Québec were used to analyze prescriptions for smoking cessation medication issued to persons insured under the public drug insurance plan.

Correlation of wavefront data and corneal asphericity with contrast sensitivity after laser in situ keratomileusis for myopia.

Purpose: To investigate the relationship between contrast sensitivity (CS), Zernike wavefront aberrations (WFA), and asphericity after laser in situ keratomileusis (LASIK) for myopia.

Methods: LASIK was performed using the Nidek EC-5000 excimer laser with custom aspheric transition zone (CATz) ablations. Total and high order (HO) WFA of 71 eyes (37 patients) undergoing LASIK in March 2003 were measured before and at 1 month postoperatively with the Nidek OPD-Scan aberrometer at a 4-mm pupil entrance; asphericity was measured at 6 mm (Q index).

Initial results of endothelial cell counts after Artisan lens for phakic eyes: an evaluation of the United States Food and Drug Administration Ophtec Study.

Purpose: To evaluate the endothelial cell count change in eyes implanted with the iris-claw phakic Artisan lens for treatment of moderate to high myopia.

Design: Prospective, multicenter clinical trial.

Participants: The first 765 eyes enrolled at 25 North American sites in the United States Food and Drug Administration Ophtec clinical trial of the myopic Artisan IOL.

Refractive lens exchange versus iris-claw Artisan phakic intraocular lens for hyperopia.

Purpose: To study a paired-match comparison between refractive lens exchange with pseudophakic IOL implant (RLE) and Artisan phakic IOL for high hyperopia.

Methods: Nineteen eyes (12 patients, 20 to 41 years old) with an Artisan phakic IOL (Model 203: 1.00-D increment) for hyperopia from +2.

Risk factors for night vision complaints after LASIK for myopia.

Purpose: To study the preoperative risk factors for night vision complaints (NVCs) after LASIK in a clinical setting.

Design: Retrospective noncomparative case series.

Participants: Seven hundred ninety-five patients (1488 eyes) who underwent LASIK for myopia up to -9.

Ultrasound biomicroscopy of the Artisan phakic intraocular lens in hyperopic eyes.

Purpose: To study in situ the intraocular position of the Artisan iris-claw intraocular lens (IOL) (model 203) (Ophtec) in phakic hyperopic eyes using ultrasound biomicroscopy (UBM).

Methods: Echograms of the anterior chamber were taken preoperatively and 24 to 317 days postoperatively in 4 eyes implanted with the Artisan IOL (power +4.0 to +6.

Comparison of the pupil card and pupillometer in measuring pupil size.

Purpose: To determine the difference in pupil size measured with the Colvard pupillometer in mesopic and scotopic luminance and with the Rosenbaum pupil card in mesopic luminance between 2 examiners.

Setting: Michel Pop Clinics, Montreal, Quebec, Canada.

Methods: Two examiners used the Colvard pupillometer and the Rosenbaum card to measure pupil size in 58 eyes.