Publications by authors named "Yuzuru Hosoda"
Article Synopsis
- - A 63-year-old man with adult T-cell leukemia-lymphoma received a bone marrow transplant from an unrelated donor and was later diagnosed with invasive pulmonary aspergillosis (IPA) 17 days post-transplant.
- - He initially improved with treatment using liposomal amphotericin B, but was switched to voriconazole due to worsening kidney function, and later experienced neurological issues.
- - The patient passed away on day 62, with an autopsy revealing fungal infection in the lungs and a ruptured cerebral aneurysm, emphasizing the need for careful monitoring of transplant patients for fungal-related complications.
Article Synopsis
- A 58-year-old female with a history of bone marrow transplantation for myelodysplastic syndrome developed invasive pneumococcal disease (IPD) 14 years post-transplant.
- Despite being vaccinated against pneumococcus twice in the past, she presented with pneumonia and was hospitalized with a confirmed infection, receiving antibiotics.
- Unfortunately, she passed away three days later, highlighting the need for ongoing vigilance and preventive strategies against pneumococcal infections long after stem cell transplantation.
Article Synopsis
- Diffuse large B-cell lymphoma, not otherwise specified (DLBCL-NOS) is the most common type of lymphoma, and this study explores the clinical factors related to MYC protein expression in patients.
- A total of 110 DLBCL-NOS patients treated with R-CHOP chemotherapy were analyzed, revealing that a higher MYC positivity rate (above 55%) correlated with lower overall survival rates (57.7% vs 84.7%) and progression-free survival rates.
- The study proposes a new scoring system categorizing patients based on age, MYC positivity, and interleukin-2 receptor levels, which effectively stratifies risk and predicts survival outcomes, with survival rates of 100%, 83
Chronic active Epstein-Barr virus infection (CAEBV) is a subtype of EBV-associated T/NK cell lymphoproliferative disease and is only curable by allogeneic hematopoietic stem cell transplantation. However, finding a human leukocyte antigen (HLA)-matched donor at a suitable time can sometimes be difficult. We report the case of a 60-year-old woman who received prednisolone (PSL) after being diagnosed with autoimmune hepatitis 3 years earlier.
View Article and Find Full Text PDFBackground: Emicizumab, a bispecific monoclonal antibody for hemophilia A (HA), has strong pharmacodynamic effects in several coagulation assays resulting in dosing difficulties with Factor VIII (FVIII) concentrates during bleeding emergencies.
Materials And Methods: Single and multiple regression models were studied to estimate FVIII activity using 27 archived plasma samples from three patients with HA without inhibitor under emicizumab treatment. Explanatory variables were FVIII chromogenic assay (CSA), Ad|min1|, Ad|min2|, the number of seconds of APTT, and the FVIII one-stage assay (OSA), which were measured without idiotype antibodies.
A 60-year-old woman developed a fifth thoracic spine fracture with progressive paraplegia and underwent posterior spine fusion in June 2018. Based on the histopathological analysis of the surgical specimen, she was diagnosed with KIT D816V-positive systemic mastocytosis (SM). In June 2019, peripheral blood examination revealed remarkable eosinophilia.
View Article and Find Full Text PDFBackground: Several prognostic indices for diffuse large B-cell lymphoma (DLBCL) have been developed. Which index is appropriate for Japanese patients with DLBCL treated in real-world practice is unknown.
Methods: The prognostic performances of the original international prognostic index (IPI), age-adjusted IPI, National Comprehensive Cancer Network-IPI, elderly IPI and revised IPI were compared using patients with DLBCL treated in a single institute in the Yonago area in Japan.
Chemotherapy for lymphoma may be avoided in the presence of coincident cytopenia. In case of immune cytopenia secondary to lymphoma, treatment of cytopenia is the same for primary cases, however, chemotherapy for lymphoma may be effective at the cost of severe hematological toxicity. The present study reports a complex case of thrombocytopenia and direct antiglobulin test-negative hemolytic anemia, thus mimicking Evans syndrome, secondary to cluster of differentiation 5-positive B-cell lymphoma with massive splenomegaly, in a patient suffering from rheumatoid arthritis for two decades.
View Article and Find Full Text PDFA 73-year-old man with a history of lethargy, fever and dyspnea was admitted to Tottori University Hospital. A computed tomography (CT) scan revealed splenomegaly and diffusely spreading ground-glass opacities (GGOs) in both lungs. A video-assisted thoracoscopic surgery (VATS)-guided lung biopsy revealed intravascular proliferation of large atypical lymphoid cells in the arteries, veins and alveolar walls.
View Article and Find Full Text PDFBackground: Acute promyelocytic leukemia (APL) is a disease characterized by expression of α (α) chimeric mRNA. Although APL is curable, early death due to hemorrhage is a major problem. Here, we report the development of a simple and rapid diagnostic method for APL based on reverse transcription loop-mediated isothermal amplification (RT-LAMP).
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