Publications by authors named "Yuzo Kawashima"
Article Synopsis
- TPA application to transgenic mice resulted in high tumor incidence, with rates increasing steadily over 9 weeks.
- Exposure to blue light after TPA decreased tumor incidence and size significantly.
- Histological examination indicated that while TPA caused various skin changes, blue light treatment led to more severe keratinization, suggesting potential therapeutic benefits in skin tumor management.
Article Synopsis
- The study examined how blue light affects B16 melanoma cells and their ability to spread to the lungs in mice.
- B16 melanoma cells exposed to blue light showed reduced growth for a week, but then their growth returned to normal levels when incubated further.
- Mice injected with melanoma cells exposed to blue light had delayed and smaller lung nodules compared to those that were not exposed, indicating that blue light may help suppress the spread of these cancer cells.
Article Synopsis
- The study investigates the effects of blue light on cell growth in leukemia patients through extracorporeal circulation therapy.
- While circulating HL60 leukemia cells exposed to blue light for 5 hours showed significant growth suppression,
- experiments with rat blood had similar results; leukemic cells were inhibited after 3 hours of exposure, while normal lymphocytes remained unaffected.
- This indicates that blue light may selectively target and suppress cancer cells more effectively than normal cells.
Although a number of studies have been carried out to examine the biological effects of radiation and ultraviolet radiation (UV), little is known concerning the effects of visible light. In the present study, exposure of B16 melanoma cells to blue light (wavelength 470 nm, irradiance 5.7 mW / cm(2)) from a light-emitting diode (LED) inhibited cell growth in proportion to the period of exposure, with no increase observed in the number of dead cells.
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