Hyaluronic acid modified Cu/Mn-doped metal-organic framework nanocatalyst for chemodynamic therapy.

Chemodynamic therapy (CDT) is a new method for cancer treatment that produces highly toxic reactive oxygen species (ROS) in the tumor microenvironment to induce cancer cell apoptosis or necrosis. However, the therapeutic effect of CDT is often hindered by intracellular HOdeficiency and the activity of antioxidants such as glutathione (GSH). In this study, a nano-catalyst HCM was developed using a self-assembled Cu/Mn-doped metal-organic framework, and its surface was modified with hyaluronic acid to construct a tumor-targeting CDT therapeutic agent with improved the efficiency and specificity.

Research Progress on the Mechanism and Function of Histone Acetylation Regulating the Interaction between Pathogenic Fungi and Plant Hosts.

Histone acetylation is a crucial epigenetic modification, one that holds the key to regulating gene expression by meticulously modulating the conformation of chromatin. Most histone acetylation enzymes (HATs) and deacetylation enzymes (HDACs) in fungi were originally discovered in yeast. The functions and mechanisms of HATs and HDACs in yeast that have been documented offer us an excellent entry point for gaining insights into these two types of enzymes.

Molecular Iridium Catalyzed Electrochemical Formic Acid Oxidation: Mechanistic Insights.

Electrochemical formic acid oxidation reaction (FAOR) is a pivotal model for understanding organic fuel oxidation and advancing sustainable energy technologies. Here, we present mechanistic insights into a novel molecular-like iridium catalyst (Ir-N-C) for FAOR. Our studies reveal that isolated sites facilitate a preferential dehydrogenation pathway, circumventing catalyst poisoning and exhibiting high inherent activity.

N-methyl Formamide Electrolyte Additive Enabling Highly Reversible Zn Anodes.

Parasitic side reactions and dendrites formation hinder the application of aqueous zinc ion batteries due to inferior cycling life and low reversibility. Against this background, N-methyl formamide (NMF), a multi-function electrolyte additive is applied to enhance the electrochemical performance. Studied via advanced synchrotron radiation spectroscopy and DFT calculations, the NMF additive simultaneously modifies the Zn solvation structure and ensures uniform zinc deposition, thus suppressing both parasitic side reactions and dendrite formation.

Phase Engineering and Synchrotron-Based Study on Two-Dimensional Energy Nanomaterials.

In recent years, there has been significant interest in the development of two-dimensional (2D) nanomaterials with unique physicochemical properties for various energy applications. These properties are often derived from the phase structures established through a range of physical and chemical design strategies. A concrete analysis of the phase structures and real reaction mechanisms of 2D energy nanomaterials requires advanced characterization methods that offer valuable information as much as possible.

Asymmetric dinitrogen-coordinated nickel single-atomic sites for efficient CO electroreduction.

Developing highly efficient, selective and low-overpotential electrocatalysts for carbon dioxide (CO) reduction is crucial. This study reports an efficient Ni single-atom catalyst coordinated with pyrrolic nitrogen and pyridinic nitrogen for CO reduction to carbon monoxide (CO). In flow cell experiments, the catalyst achieves a CO partial current density of 20.

Insights into an NEk2 inhibitory profile of nitidine chloride by molecular docking and biological evaluation.

Deregulation of NEK2(NIMA-related serine/threonine 2) confers chemotherapeutic resistance to apoptosis and is closely correlated with poor prognosis in hepatocellular carcinoma (HCC). Here, we find that nanoparticles are prepared through hemisynthesis from natural nitidine chloride (NC) with enhanced antitumor activity. Nitidine chloride nanoparticle (TPGS-FA/NC) treatment show good therapy effect in Li-7 hepatocellular carcinoma cells.

A novel nitidine chloride nanoparticle overcomes the stemness of CD133EPCAM Huh7 hepatocellular carcinoma cells for liver cancer therapy.

Background: Stemness of CD133EPCAM hepatocellular carcinoma cells ensures cancer resistance to apoptosis,which is a challenge to current liver cancer treatments. In this study, we evaluated the tumorcidal activity of a novel nanoparticle of nitidine chloride (TPGS-FA/NC, TPGS-FA: folic acid modified D-α-tocopheryl polyethylene glycol 1000 succinate, NC: nitidine chloride), against human hepatocellular carcinoma (HCC) cell line Huh7 growth in vitro and in vivo.

Methods: Huh7 cells were treated with TPGS-FA/NC.

Confining High-Valence Iridium Single Sites onto Nickel Oxyhydroxide for Robust Oxygen Evolution.

Enhancing activity and stability of iridium- (Ir-) based oxygen evolution reaction (OER) catalysts is of great significance in practice. Here, we report a vacancy-rich nickel hydroxide stabilized Ir single-atom catalyst (Ir-Ni(OH)), which achieves long-term OER stability over 260 h and much higher mass activity than commercial IrO in alkaline media. In situ X-ray absorption spectroscopy analysis certifies the obvious structure reconstruction of catalyst in OER.

Synergic Reaction Kinetics over Adjacent Ruthenium Sites for Superb Hydrogen Generation in Alkaline Media.

Ruthenium (Ru)-based electrocatalysts as platinum (Pt) alternatives in catalyzing hydrogen evolution reaction (HER) are promising. However, achieving efficient reaction processes on Ru catalysts is still a challenge, especially in alkaline media. Here, the well-dispersed Ru nanoparticles with adjacent Ru single atoms on carbon substrate (Ru -NC) is demonstrated to be a superb electrocatalyst for alkaline HER.

Localized Defects on Copper Sulfide Surface for Enhanced Plasmon Resonance and Water Splitting.

Surficial defects in semiconductor can induce high density of carriers and cause localized surface plasmon resonance which is prone to light harvesting and energy conversion, while internal defects may cause serious recombination of electrons and holes. Thus, it is significant to precisely control the distribution of defects, although there are few successful examples. Herein, an effective strategy to confine abundant defects within the surface layer of Cu S nanoflake arrays (NFAs) is reported, leaving a perfect internal structure.

Freestanding Ultrathin Metallic Nanosheets: Materials, Synthesis, and Applications.

Freestanding ultrathin metallic nanosheets (FUMNSs) with atomic thickness attract extensive attention because they display remarkable advantages over their bulk counterparts by virtue of their large specific area, high aspect ratio, and unsaturated surface coordination. The state of the art of research on FUMNSs is reviewed here, wherein the important progress from the aspects of material category, synthetic strategy, and practical application are introduced, and it is demonstrated that FUMNSs will play an important role in the fields of optoelectrics, catalysis, and magnetism.

[Detection and functional analysis of CD-4+ CD-25+ regulatory T cells in the peripheral blood of patients with generalized aggressive periodontitis].

Objective: To investigate the changes of proportion and suppression function of CD-4+ CD-25+ regulatory T cells in the peripheral blood of patients with aggressive periodontitis.

Methods: Flow cytometric analysis was used to detect the frequency of CD-4+ CD-25+ regulatory T cells in the peripheral blood of 16 patients with generalized aggressive periodontitis and 17 patients with chronic periodontitis, as well as 17 periodontal healthy controls. Furthermore, CD-4+ CD-25+ regulatory T cells and CD-4+ CD-25- T cells were separated from peripheral blood of each enrolling subject using magnetic cell sorting technology.

[Use of angulated radiograph in clinical judgement of obturation quality of molars with multiple root canals].

Objective: To investigate different angle projection technique for clinical judgment of obturation quality of molars with multiple root canals.

Methods: Eighty-seven maxillary first molars with second mesiobuccal canal (MB2) and 105 mandibular first molars were selected. The canals were instrumented by Ni-Ti rotary instruments and obturated with lateral condensation technique.

[Clinical management of lateral canal perforation with MTA].

Purpose: To evaluate the clinical effect of repair of lateral root canal perforation with mineral trioxide aggregate (MTA).

Methods: 18 teeth with root canal perforation were selected. The root canals were shaped and cleaned, and then obturated with gutta-percha before or after MTA was used to repair the perforation.