Publications by authors named "Yuzhu Song"

Rabies, caused by the rabies virus (RABV; scientific name Rabies lyssavirus), is invariably fatal, and currently, there is no specific drug for its treatment. Previous studies have demonstrated the relationship between CD9 and the RABV. However, it remains unclear whether CD9 and IL-16 affect the RABV life cycle.

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An aptasensor was developed based on surface-enhanced Raman spectroscopy (SERS) to detect alpha-fetoprotein (AFP) using a mirror aptamer. AFP triggered and altered SERS signaling molecules through the release recognition mechanism as they are released. Two signaling molecules, cyanine 3 (Cy3) and 2-mercaptobenzimidazole-5-carboxylic acid (MBIA), were used to quantify AFP.

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Lattice distortion and disorder in the chemical environment of magnetic atoms within high-entropy compounds present intriguing issues in the modulation of magnetic functional compounds. However, the complexity inherent in high-entropy disordered systems has resulted in a relative scarcity of comprehensive investigations exploring the magnetic functional mechanisms of these alloys. Herein, we investigate the magnetocaloric effect (MCE) of the high-entropy intermetallic compound GdTbDyHoErCo.

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Article Synopsis
  • Iron alloys, particularly steels and magnetic materials, are crucial in various industries but struggle with high thermal expansion, limiting their precision applications.
  • A new strategy has been developed to embed a nano-scale negative thermal expansion (NTE) phase within the iron matrix, effectively reducing the thermal expansion coefficient of an example alloy (Fe-Zr10-Nb6) to about half of standard iron.
  • This alloy demonstrates impressive mechanical properties, achieving 1.5 GPa compressive strength and 17.5% ultimate strain, while the NTE phase helps counterbalance the thermal expansion, indicating a promising method for creating low thermal expansion iron alloys with enhanced performance.
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The emergence of chronic wound infections and bacterial resistance presents substantial clinical challenges that impact millions worldwide. Antimicrobial peptides (AMPs), recognized for their potent antimicrobial properties, are considered promising alternatives to conventional antibiotics in light of escalating drug resistance. In previous research, we isolated an AMP named cathelicidin-DM from Duttaphrynus melanostictus, which exhibited broad-spectrum efficacy against multidrug-resistant bacteria and demonstrated wound-healing capabilities.

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Tuberculosis is a highly infectious bacterial disease caused by . The spread of this agent has caused serious health problems worldwide, and the rapid and accurate detection of is essential for controlling the spread of infection and for preventing the emergence of multidrug-resistant strains. In this study, the cleavage ability of CRISPR-Cas12a against single-stranded DNA was combined with hybridization chain reaction and chemiluminescent signal to establish an imaging sensor for the hypersensitive detection of DNA.

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Tuberculosis is a highly infectious disease caused by the bacterium Mycobacterium tuberculosis, and the spread of this agent has caused serious health problems worldwide. The rapid and accurate detection of M. tuberculosis is essential for controlling the spread of infection and for preventing the emergence of multidrug-resistant strains.

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  • Vancomycin is a key antibiotic for treating MRSA infections, but its overuse has led to increased bacterial resistance, prompting this study to find better alternatives.
  • The research analyzed data from 38 trials involving 6,281 patients, measuring clinical success rates and adverse reactions of various antibiotics, including linezolid and combinations of other drugs with vancomycin.
  • Results indicated that linezolid and certain drug combinations outperformed vancomycin in treating MRSA infections, showing higher success rates and lower resistance, while also highlighting the risks of more side effects with some treatments.
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  • * Research highlights the large barocaloric effect (BCE) in MnPt, showing a significant temperature change strength of 9.77 K per 100 MPa, driven by low pressure and geometrical frustration.
  • * The study reveals that geometrical frustration enhances BCE by inducing strong spin fluctuations and magnetic moment changes, leading to greater sensitivity in magnetic phase transitions and advancing barocaloric refrigeration research.
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This study investigated the effects of pulp (LBP) on the properties of mixed dough and gluten protein. The results showed that appropriate addition of LBP (5 %) significantly improved the performance of the dough, promoted the aggregation of gluten protein, enhanced the water binding ability, and delayed the gelatinization of starch during cooking. Compared with the control group, the peak temperature (T) of the LBP sample gradually increased from 63.

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  • * A new strategy enhances the thermal conductivity and machinability of negative thermal expansion alloy (Zr,Nb)Fe by incorporating eutectic copper networks, resulting in over 200% increased thermal conductivity and improved mechanical strength.
  • * The addition of copper modifies the (Zr,Nb)Fe composition, leading to better thermal management and stability across a wider temperature range, while also improving bonding and stress handling capabilities of the alloy.
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New drugs for the treatment of bacterial vaginosis (BV) are yet to be developed due to concerns that they may contribute to the increase in antibiotic resistance in BV. Antimicrobial peptides (AMPs) are one of the most promising options for next-generation antibiotics. In this study, we investigated the bacteriostatic activity of the AMPs Pexiganan, plectasin, melittin, and cathelicidin-DM against Gram-negative and Gram-positive bacteria both and in a mouse model of BV infection.

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Nanozyme-mediated antioxidative therapy is a promising star for treating a myriad of important diseases through eliminating excessive reactive oxygen species (ROS) such as O and HO, a critical mechanism for inflammatory bowel disease (IBD). This work provides a high biocompatibility iodine-copper-zinc covalent doped carbon dots (Cu,Zn,I-CDs) with the catalase (CAT)-, superoxide dismutase (SOD)- and glutathione peroxidase (GPx)-like catalytic activities for treating ulcerative colitis (UC) by scavenging overproduced ROS. We found that I dopant aids in counteracting the positive charge at Cu,Zn dopants brought on by low pH, enabling Cu,Zn,I-CDs to process strong triple antioxidant nanozyme activities rather than Cu,Zn-CDs.

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The aim of this study was to prepare active intelligent gluten protein films using wheat gluten protein (WG) and apple pectin (AP) as film-forming matrices, and blueberry anthocyanin extract (BAE) as a natural indicator. SEM and FT-IR analyses demonstrated the successful immobilization of BAE in the film matrix by hydrogen bonding interactions and its compatibility with WG and AP. The resultant WG-AP/BAE indicator films demonstrated notable antioxidant activity, color stability, barrier qualities, pH and ammonia response sensitivity, and mechanical properties.

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Magnetic refrigeration technology can achieve higher energy efficiency based on the magnetocaloric effect (MCE). However, the practical application of MCE materials is hindered by their poor mechanical properties, making them challenging to process into devices. Conventional strengthening strategies usually lead to a trade-off with refrigeration capacity reduction.

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Antibiotic resistance has emerged as a grave threat to global public health, leading to an increasing number of treatment failures. Antimicrobial peptides (AMPs) are widely regarded as potential substitutes for traditional antibiotics since they are less likely to induce resistance when used. A novel AMP named Brevinin-1BW (FLPLLAGLAASFLPTIFCKISRKC) was obtained by the Research Center of Molecular Medicine of Yunnan Province from the skin of the .

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Objective: The limited existing knowledge regarding resistance to antimicrobial peptides (AMPs) is hindering their broad utilization. The aim of this study is to enhance the understanding of AMP resistance, a pivotal factor in the exploration of alternative drug development in response to the escalating challenge of antibiotic resistance.

Methods: We utilized metagenomic functional selection to analyze genes resistant to AMPs, with a specific focus on the microbiota in soil and the human gut.

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Japanese encephalitis virus (JEV), a member of the Flaviviridae family and a flavivirus, is known to induce acute encephalitis. Vimentin protein has been identified as a potential receptor for JEV, engaging in interactions with the viral membrane protein. The Fc fragment, an integral constituent of immunoglobulins, plays a crucial role in antigen recognition by dendritic cells (DCs) or phagocytes, leading to subsequent antigen presentation, cytotoxicity, or phagocytosis.

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Accidental ingestion of poisonous mushrooms leading to poisoning is a global issue. The most important and lethal toxin causing mushroom poisoning is α-amanitin, with a lethal dose of about 0.1 mg kg.

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Hepatitis B virus (HBV) infection is a global public health problem that is closely related to liver cirrhosis and hepatocellular carcinoma (HCC). The prevalence of acute and chronic HBV infection, liver cirrhosis, and HCC has significantly decreased as a result of the introduction of universal HBV vaccination programs. The first hepatitis B vaccine approved was developed by purifying the hepatitis B surface antigen (HBsAg) from the plasma of asymptomatic HBsAg carriers.

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Gastrointestinal cancer is a common clinical malignant tumor disease that seriously endangers human health and lacks effective treatment methods. As part of the innate immune defense of many organisms, antimicrobial peptides not only have broad-spectrum antibacterial activity but also can specifically kill tumor cells. The positive charge of antimicrobial peptides under neutral conditions determines their high selectivity to tumor cells.

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Article Synopsis
  • Rabies is a deadly virus that has plagued humans for centuries, with nearly a 100% fatality rate, leading researchers to seek effective vaccines.
  • This study involved creating a rabies DNA vaccine by using E. coli to deliver a highly antigenic polypeptide that targets the rabies virus, assembled in a specific expression vector.
  • Experimental results showed that the vaccine successfully triggered antibody production in mice and improved their survival when exposed to the virus, suggesting that utilizing food-borne microorganisms as delivery vehicles could be a promising strategy in rabies eradication efforts.
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Methylmercury (MeHg) is a common form of organic mercury that is substantially more toxic than inorganic mercury and is more likely to accumulate in organisms through biological enrichment. Therefore, developing a method to enable the specific and rapid detection of MeHg in seafood is important and remains challenging to accomplish. Herein, a rapid, label-free fluorescence detection method for MeHg determination was developed based on SYBR Green I.

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Magnetic skyrmions are topologically protected quasiparticles that are promising for applications in spintronics. However, the low stability of most magnetic skyrmions leads to either a narrow temperature range in which they can exist, a low density of skyrmions, or the need for an external magnetic field, which greatly limits their wide application. In this study, high-density, spontaneous magnetic biskyrmions existing within a wide temperature range and without the need for a magnetic field were formed in ferrimagnets owing to the existence of a negative thermal expansion of the lattice.

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Negative thermal expansion (NTE) alloys possess great practical merit as thermal offsets for positive thermal expansion due to its metallic properties. However, achieving a large NTE with a wide temperature range remains a great challenge. Herein, a metallic framework-like material FeZr is found to exhibit a giant uniaxial (1D) NTE with a wide temperature range (93-1078 K, [Formula: see text]).

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