An adeno-associated virus-mediated immunotherapy for Alzheimer's disease.

Disease-modifying passive immunotherapies focusing on removal of abnormal phosphorylated Tau (p-Tau) constitute promising treatments for Alzheimer's disease (AD). Although several prior immunotherapies targeting p-Tau appear to be beneficial against AD, they have limitations such as the low blood-brain barrier (BBB) penetration rate, short half-life of antibodies, and the likelihood of inflammation. To address these issues, we designed a novel immunotherapy for AD.

Occurrence and risks of antibiotics in an urban river in northeastern Tibetan Plateau.

There is a dearth of information on the occurrence and risks of antibiotics in the urban rivers from plateau areas. This study investigated 83 antibiotics in water and sediments of an urban river and effluents of sewage treatment plants (E-STPs) in Xining, Qinghai (northeastern Tibetan Plateau). Fifty-three antibiotics were detected, and the concentrations of individual antibiotics varied in the range of undetected (ND)-552 ng/L in water, ND-164 ng/g in sediments, and ND-3821 ng/L in E-STPs.

Enrichment of antibiotics in an inland lake water.

Inland water is very susceptible to the input of pollutants. However, little is known about the occurrence of antibiotics in inland lakes. In this study, a total of 83 target antibiotics were quantified in water and sediment samples collected from the Qinghai Lake, the largest inland lake of China located on the northeast of Qinghai-Tibet plateau, and its inflowing rivers.

Occurrence and removal of antibiotics and antibiotic resistance genes in natural and constructed riverine wetlands in Beijing, China.

Simultaneous elimination of antibiotics and antibiotic resistance genes (ARGs) is rarely investigated in full-scale riverine wetlands. Here, we compared the occurrence, abundance, and removal of 60 antibiotics and 27 ARGs in natural (Yeya Lake (YL)) and constructed (Bai River (BR)) riverine wetlands in Beijing, China. The concentrations of antibiotics in YL wetland were ND-51.

Antibiotics in water and sediments of Danjiangkou Reservoir, China: Spatiotemporal distribution and indicator screening.

Danjiangkou Reservoir is the largest artificial freshwater lake in China. The occurrence and spatiotemporal distribution of 77 antibiotics in water and sediment samples from Danjiangkou Reservoir were investigated. Approximately 90% of the detectable concentrations of the 61 and 54 antibiotics found in water and sediment samples were lower than 5.