Highly sensitive electrochemical quantification of carbendazim via synergistic enhancement of ring-opening metathesis polymerization and polyethyleneimine modified graphene oxide.

A novel aptamer-based sensor was developed using the signal amplification strategy of ring-opening metathesis polymerization (ROMP) and polyethyleneimine modified graphene oxide to achieve trace detection of carbendazim (CBZ). The dual identification of aptamer and antibody was used to avoid false positive results and improve the selectivity. Polyethyleneimine modified graphene oxide (GO-PEI), as a substrate material with excellent conductivity, was modified on the surface of a glassy carbon electrode (GCE) to increase the grafting amount of aptamer on the electrode surface.

A controllable Y-shaped DNA structure assisted aptasensor for the simultaneous detection of AFB and OTA based on ARGET ATRP.

The development of a simple, rapid, and sensitive technology for the simultaneous detection of mycotoxins is of great significance in ensuring the safety of foods and drugs. Herein, a fluorescence aptasensor with high sensitivity and reproducibility for the simultaneous detection of aflatoxin B (AFB) and ochratoxin A (OTA) was developed. In this sensing system, AFB and OTA aptamers were co-immobilized on the surface of magnetic beads (MBs) to form a Y-shaped structure through the principle of complementary base pairing, and were used as recognition probes to specifically capture the target.

Sex-dependent difference in the relationship between thyroid hormones and gallstone disease in euthyroid subjects.

The relationship between thyroid dysfunction and gallstone disease (GSD) has been examined by some observational studies. However, evidence about the relationship between thyroid function and GSD among euthyroid subjects was scarce. The aim of this study was to investigate the association between thyroid function and the presence of GSD in a large-sample euthyroid subjects.

RFTN1 facilitates gastric cancer progression by modulating AKT/p38 signaling pathways.

Gastric cancer (GC), a malignant tumor originating from the epithelium of the gastric mucosa, has been endangering human health for many years. The current standard surgical resection is not ideal for advanced gastric cancer. Therefore, it is urgent to find new prognostic indicators as well as drug targets.

Control of Laves Precipitation in a FeCrAl-based Alloy Through Severe Thermomechanical Processing.

In recent years, the development of nuclear grade FeCrAl-based alloys with enhanced accident tolerance has been carried out for light water reactor (LWR) fuel cladding to serve as a substitute for zirconium-based alloys. To achieve excellent microstructure stability and mechanical properties, the control of precipitation particles is critical for application of FeCrAl-based alloys. In this paper, the effect of thermomechanical processing on the microstructure and precipitation behavior of hot-rolled FeCrAl alloy plates was examined.

Influence of grapefruit juice on pharmacokinetics of triptolide in rats grapefruit juice on the effects of triptolide.

1. Triptolide, a major pharmacological component isolated from Tripterygium wilfordii Hook F (TWHF), is a substrate of both CYP3A4 and P-glycoprotein (P-gp). 2.

Effects of type 2 diabetes mellitus on the pharmacokinetics of berberine in rats.

Context: Berberine is an active alkaloid isolated from Rhizoma coptidis [Coptis chinensis Franch. (Ranunculaceae)] that is widely used for the treatment of diabetes, hyperlipidemia and hypertension. However, the pharmacokinetics of berberine in normal rats and type 2 diabetes mellitus (T2DM) model rats are not clear.