Publications by authors named "Yuzhao Jin"
Ubiquitination-related Gene UBTD1 Mediates Poor Prognosis of Colorectal Cancer and Affects Colorectal Cancer Cell Proliferation and Ferroptosis.
Recent Pat Anticancer Drug Discov
January 2025
Background: Colorectal cancer (CRC) is the third most common cancer worldwide, and its occurrence and progression are often regulated by genetic and hereditary factors. Ubiquitination and the associated ubiquitin-binding enzymes and ligases regulate the tumor microenvironment and antitumor immunity to mediate tumor pathogenesis and progression. In this study, we examined the molecular characteristics and immunomodulatory effects of ubiquitination-associated genes that mediate CRC prognosis.
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- After RFA treatment for liver cancer, there's a notable increase in the expression of /xCT and the number of dendritic cells (DCs) in the tumor microenvironment (TME).
- /xCT is associated with poor prognosis in liver cancer and is primarily found in DCs within the TME.
- Combining xCT targeting in DCs with RFA treatment boosts anti-tumor immune responses, reduces tumor growth, and suggests a potential strategy for better treatment outcomes in liver cancer.
Radiotherapy (RT) remodels the tumor immune microenvironment (TIME) and modulates the immune response to indirectly destroy tumor cells, in addition to directly killing tumor cells. RT combined with immunotherapy may significantly enhance the efficacy of RT in colorectal cancer by modulating the microenvironment. However, the molecular mechanisms by which RT acts as an immunomodulator to modulate the immune microenvironment remain unclear.
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