Publications by authors named "Yuze Mi"
Background: Observational studies suggest that gut microbiome (GM) may contribute to acute anterior uveitis (AAU) development, but causality remains unclear. This study was conducted to test whether specific GM taxa were causally associated with AAU.
Methods: The GM data were obtained from the DMP, which included 7738 individuals' faecal samples and an analysis of host genotype-taxa abundance associations.
Article Synopsis
- - High myopia is increasingly linked to blindness and can negatively affect mental health by influencing the brain and gut microbiome, making it important for understanding overall health connections.
- - The study hypothesized that visual issues from high myopia might disrupt gut health, potentially leading to anxiety and depression, testing this through genetic analysis in large cohorts.
- - Results indicated a significant genetic link between high myopia and anxiety, with part of this effect mediated by gut microbiome changes, suggesting a need for new approaches in preventive medicine.
The causal association between plasma caffeine and frailty: A two-sample mendelian randomization study.
Arch Gerontol Geriatr
March 2025
Article Synopsis
- The study investigates the causal link between caffeine in the blood and frailty in older adults, amidst previous observational claims that caffeine may reduce frailty risk.
- Researchers used a Mendelian Randomization analysis with data from large cohorts (over 175,000 participants) to determine the effect of genetic variations related to caffeine on frailty measurements.
- Results showed a significant negative association between higher plasma caffeine levels and measures of frailty, suggesting that increased caffeine could potentially help prevent frailty in aging populations.
Purpose: We aimed to determine the causal effects of physical activities with different frequencies, durations, and intensities on the risk of senile cataracts using Mendelian randomization (MR).
Methods: A bidirectional two-sample MR approach was used to determine the association between physical activity and senile cataract risk. Our primary analysis used the inverse variance weighted method, and secondary analyses included MR-Egger regression, MR-PRESSO, and Cochran's Q statistic to evaluate heterogeneity and pleiotropy.
Objectives: In this study, we compared the dynamic changes in body composition during XELOX/SOX chemotherapy in patients with gastric cancer. Furthermore, we investigated the potential impact of these changes on the occurrence of toxic side effects.
Methods: Patients with gastric cancer who received adjuvant or first-line XELOX/SOX chemotherapy between January 2020 and June 2023 were enrolled.
Age-related eye diseases (AREDs), including age-related cataracts (ARCs), age-related macular degeneration (AMD), diabetic retinopathy (DR), and glaucoma, are a leading cause of visual loss globally. This study aimed to explore the effects of dietary water intake on AREDs using Mendelian randomization. In the European population, genome-wide association study (GWAS) summary statistics of water intake and AREDs were obtained from the UK Biobank database and the FinnGen Consortium, respectively.
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