Cinnamaldehyde nanoemulsion decorated with rhamnolipid for inhibition of methicillin-resistant biofilm formation: and assessment.

Background: () biofilm associated infections are prevalent and persistent, posing a serious threat to human health and causing significant economic losses in animal husbandry. Nanoemulsions demonstrate significant potential in the treatment of bacterial biofilm associated infections due to their unique physical, chemical and biological properties. In this study, a novel cinnamaldehyde nanoemulsion with the ability to penetrate biofilm structures and eliminate biofilms was developed.

Cinnamaldehyde Restores Ceftriaxone Susceptibility against Multidrug-Resistant .

In recent years, infections caused by multidrug-resistant (MDR) bacteria have greatly threatened human health and imposed a burden on global public health. To overcome this crisis, there is an urgent need to seek effective alternatives to single antibiotic therapy to circumvent drug resistance and prevent MDR bacteria. According to previous reports, cinnamaldehyde exerts antibacterial activity against drug-resistant spp.

Cinnamaldehyde Resist Typhimurium Adhesion by Inhibiting Type I Fimbriae.

Typhimurium (. Typhimurium), a common foodborne pathogen, severely harms the public and food security. Type I fimbriae (T1F) of .

Geraniol inhibits biofilm formation of methicillin-resistant and increase the therapeutic effect of vancomycin .

Methicillin-resistant (MRSA) is among the common drug resistant bacteria, which has gained worldwide attention due to its high drug resistance and infection rates. Biofilms produced by are known to increase antibiotic resistance, making the treatment of infections even more challenging. Hence, inhibition of biofilm formation has become an alternative strategy for controlling persistent infections.

Thymol Inhibits Biofilm Formation, Eliminates Pre-Existing Biofilms, and Enhances Clearance of Methicillin-Resistant (MRSA) in a Mouse Peritoneal Implant Infection Model.

Methicillin-resistant (MRSA) is a common human pathogen that causes several difficult-to-treat infections, including biofilm-associated infections. The biofilm-forming ability of plays a pivotal role in its resistance to most currently available antibiotics, including vancomycin, which is the first-choice drug for treating MRSA infections. In this study, the ability of thymol (a monoterpenoid phenol isolated from plants) to inhibit biofilm formation and to eliminate mature biofilms, was assessed.