Genetically Engineered Macrophages Co-Loaded with CD47 Inhibitors Synergistically Reconstruct Efferocytosis and Improve Cardiac Remodeling Post Myocardial Ischemia Reperfusion Injury.

Efferocytosis, mediated by the macrophage receptor MerTK (myeloid-epithelial-reproductive tyrosine kinase), is a significant contributor to cardiac repair after myocardial ischemia-reperfusion (MI/R) injury. However, the death of resident cardiac macrophages (main effector cells), inactivation of MerTK （main effector receptor), and overexpression of "do not eat me" signals (brake signals, such as CD47), collectively lead to the impediment of efferocytosis in the post-MI/R heart. To date, therapeutic strategies targeting individual above obstacles are relatively lacking, let alone their effectiveness being limited due to constraints from the other concurrent two.

High resolution mapping of nighttime light and air pollutants during the COVID-19 lockdown in Wuhan.

Unlabelled: The novel coronavirus (COVID-19) has induced unprecedented improvements of air quality due to drastic shrinking of human activities during the pandemic lockdown in 2020. While declines of most air pollutants have been globally evidenced in most cities worldwide, there is few detailed spatial knowledge at local scale. Therefore, we present here a high resolution mapping of the 2018-2020 evolution of human activities and air pollutants in Wuhan.