Publications by authors named "Yuying Pang"
The combination of poorly-soluble drugs with small molecule co-formers to generate amorphous solid dispersions (ASDs) has great potential to improve dissolution rate and kinetic solubility, and thus increase the bioavailability of these active ingredients. However, such ASDs are known to be unstable and to crystallise upon storage or heating. In this work, we explore the crystallisation of flufenamic acid (FFA) from ASDs prepared with trehalose.
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- Flufenamic acid (FFA) is a drug with nine known crystal structures, and this study investigates how different polymers affect its crystallization and phase transitions when heated.* -
- By using a technique that combines X-ray powder diffraction and differential scanning calorimetry, researchers found that certain polymers can stabilize a specific FFA form, preventing it from transitioning to another form during heating.* -
- The study shows that the chemical makeup of the polymers has a greater influence on preventing these transitions than their viscosity, and an unknown polymorph of FFA was identified but not fully characterized.*
Co-crystallisation is widely explored as a route to improve the physical properties of pharmaceutical active ingredients, but little is known about the fundamental mechanisms of the process. Herein, we apply a hyphenated differential scanning calorimetry-X-ray diffraction technique to mimic the commercial hot melt extrusion process, and explore the heat-induced synthesis of a series of new co-crystals containing isonicotinamide. These comprise a 1:1 co-crystal with 4-hydroxybenzoic acid, 2:1 and 1:2 systems with 4-hydroxyphenylacetic acid and a 1:1 crystal with 3,4-dihydroxyphenylactic acid.
View Article and Find Full Text PDF[Epidemic characteristics of student pulmonary tuberculosis analysis in Yuman province, 2013].
Zhonghua Liu Xing Bing Xue Za Zhi
June 2015
Objective: To compare the intraocular pressure (IOP) lowering effect of 0.004% travoprost and 2% carteolol in patients with ocular hypertension (OHT) after laser peripheral iridotomy (LPI) or trabeculectomy in primary angle-closure glaucoma (PACG).
Methods: Clinical case control trial.
[A novel mutation in the myocilin gene identified in a Chinese primary open angle glaucoma family].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
December 2007
Objective: To determine the possible myocilin molecular genetic defect underlying POAG in China and to identify the pathogenic mutation causing the disease.
Methods: The majority of 1 branch of a large Chinese POAG family were personally examined by two senior ophthalmologists. The diagnoses were made by both doctors according to the signs of elevated intraocular pressure, glaucomatous optic neuropathy and glaucomatous visual field defect.