Rational design of NIR-II molecule-engineered nanoplatform for preoperative downstaging and imaging-guided surgery of orthotopic hepatic tumor.

Orthotopic advanced hepatic tumor resection without precise location and preoperative downstaging may cause clinical postoperative recurrence and metastasis. Early accurate monitoring and tumor size reduction based on the multifunctional diagnostic-therapeutic integration platform could improve real-time imaging-guided resection efficacy. Here, a Near-Infrared II/Photoacoustic Imaging/Magnetic Resonance Imaging (NIR-II/PAI/MRI) organic nanoplatform IRFEP-FA-DOTA-Gd (IFDG) is developed for integrated diagnosis and treatment of orthotopic hepatic tumor.

Discovery of the Diphenyl 6-Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the JNK2-NF-κB/MAPK Pathway.

Acute lung injury (ALI) and sepsis are both serious and complex conditions associated with high mortality, yet there are no effective treatments. Herein, we designed and synthesized a series of diphenyl 6-oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide analogues exhibiting anti-inflammatory activity. The optimal compound decreased the release of TNF-α and IL-6 in mouse and human cells J774A.

Synthesis and SAR study of novel diimide skeleton compounds with the anti-inflammatory activities in vitro and in vivo.

Amide bonds widely exist in the structure of natural products and drugs, and play an important role in biological activities. However, due to the limitation of synthesis conditions, there are few studies on biscarbonyl diimides. In this paper, a series of new compounds with diimide skeleton were synthesized by using CDI and NaH as condensation agents.

Design, Synthesis, and Bioevaluation of Novel MyD88 Inhibitor c17 against Acute Lung Injury Derived from the Virtual Screen.

Myeloid differentiation primary response protein 88 (MyD88) is crucial to immune cascades mediated by Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). MyD88 dysregulation has been linked to a wide variety of inflammatory diseases, making it a promising new target for anti-inflammatory and cancer therapy development. In this study, 46 compounds were designed and synthesized inspired by virtual screen hit.

Mining phosphorus from waste streams at wastewater treatment plants: a review of enrichment, extraction, and crystallization methods.

Two interrelated problems exist: the non-renewability of phosphate rock as a resource and the excess phosphate in the water system lead to eutrophication. Removal and recovery of phosphorus (P) from waste streams at wastewater treatment plants (WWTPs) is one of the promising solutions. This paper reviews strategies for P recovery from waste streams in WWTPs are reviewed, and the main P recovery processes were broken down into three parts: enrichment, extraction, and crystallization.

Transformation and fate of non-reactive phosphorus (NRP) in enhanced biological phosphorus removal process with sidestream phosphorus recovery.

Recovery of phosphorus (P) from wastewater can help establish a new P cycle. However, there are many P forms in wastewater, not always in reactive forms, which are the most suitable for direct recovery. The enhanced biological phosphorus removal process with sidestream phosphorus recovery (EBPR-SPR) is an effective way to remove and recover P resources in wastewater, but there is a lack of research on the transformation and fate of non-reactive phosphorus (NRP) in it.

Effects of dissolved organic matter on phosphorus recovery via hydroxyapatite crystallization: New insights based on induction time.

Recovery of phosphorus from sewage can help establish a new phosphorus cycle and hydroxyapatite (HAP) crystallization is a promising way. HAP crystallization is an amorphous calcium phosphate (ACP) mediated process, and its induction time reflects the rate of HAP nucleation, and seriously affects the efficiency of phosphorus recovery. In this study, the effects of different types of dissolved organic matter (DOM) on the induction time and phosphorus recovery performance of ACP-mediated HAP phosphorus recovery were studied, and the mechanism was analyzed by X-Ray Diffraction, Fourier transform infrared spectroscopy, and scanning electron micrograph with energy dispersive spectrometry.

Application of membrane separation processes in phosphorus recovery: A review.

The depletion of phosphorus resources and the excess discharge of phosphorus into waste streams are contrasting problems. The key to solving both problems is to recover phosphorus from the waste streams. Current phosphorus recovery technologies require high phosphorus concentrations and lack the ability to separate toxic substances from recovered phosphorus products.