Background: Smoking is a factor for hypertension. We aim to reveal novel plasma proteins mediating the relationship of smoking with hypertension and identify potential drug targets for hypertension on the basis of Mendelian randomization design.
Methods And Results: Data for smoking were selected from the largest genome-wide association study meta-analysis performed by the Genome-Wide Association Study and Sequencing Consortium of Alcohol and Nicotine Use.
Mustard gas and other chemical warfare agents (CWAs) are a global threat to public security, arising from unpredictable emergencies and chemical spill accidents. So far, photocatalysts such as metal clusters, polyoxometalates and porous solids have been exploited for oxidative degradation of mustard gas, commonly with O as reactive species. However, the production of O is oxygen-dependent and requires a high oxygen concentration to sustain the detoxication process.
View Article and Find Full Text PDFBackground: Toxoplasma gondii is an intracellular opportunistic pathogenic protozoan that poses serious threats, particularly in immunocompromised individuals. In the absence of a robust prophylactic measure, the mitigation and management of toxoplasmosis present formidable challenges to public health. We recently found that GRA72 plays an important role in parasitophorous vacuole (PV) morphology, growth and virulence of T.
View Article and Find Full Text PDFIn recent years, solid-state lithium metal batteries (SSLMBs) have become a new development trend, and it has become a top priority to design solid-state electrolytes (SSEs) that can rapidly and stably transport lithium ions in a variety of climatic environments. In this work, an integrated "rigid-flexible" dual-functional strategy is proposed to develop a cationic covalent organic framework (EO-BIm-iCOF) with well-defined flexible oligo(ethylene oxide) (EO) chains as an SSE for SSLMBs. As expected, the synergistic effects of the rigid cationic framework and flexible EO chains not only promote the dissociation of LiTFSI salts, but also greatly improve the transport of lithium ions, which endows LITFSI@EO-BIm-iCOF SSEs with a high Li conductivity of 1.
View Article and Find Full Text PDFBackground: Live dietary microbes have been hypothesized to promoting human health. However, there has been lacking perceptions to crystallize nexus between consumption of foods with live microbes and mortality.
Objective: To investigate the association of consumption of foods with medium to high amounts of live microbes with all-cause, cancer-specific, and cardiovascular disease (CVD)-specific mortality.
Purpose: Osteoporosis is a common generalized skeletal disorder characterized by compromised bone strength predisposing a person to an increased risk of fracture. This study aims to crystallize associations of physical activity (PA) and sedentary behaviour with the survival of adults with osteoporosis or osteopenia.
Methods: A total of 3103 participants aged 50 years or older from the National Health and Nutrition Examination Survey (NHANES) were included in the study.
Aqueous zinc-iodine batteries (AZIBs) are attracting increasing attention because of their high safety and abundance of resources. However, the performance of AZIBs is compromised by inadequate confinement of soluble polyiodides, the undesired shuttle effect, and slow reaction kinetics. In this study, a porous aromatic framework (PAF) with abundant benzene motifs and a well-organized pore structure is adopted as the iodine host, which exhibits high iodine adsorption capacity and robust polyiodide confinement.
View Article and Find Full Text PDFPorous aromatic frameworks (PAFs) are highly promising functional porous solids known for their feasible amenability and extraordinary stability. When the framework was modified by ionic functional groups, these ionic PAFs (iPAFs) exhibited charged channels for adsorption, separation, and catalysis. However, the surface areas of ionic porous frameworks are usually lower than that of neutral frameworks, and their synthesis is limited by specific strategies and complex modification processes.
View Article and Find Full Text PDFBackground: T plays a pivotal role in the suppression of Th2 cell and the maintenance of immune homeostasis. The precise molecular mechanism underlying the disruption of T suppression of Th2 cell and the promotion of Th2 type inflammation in allergic diseases remains elusive.
Objective: This study aims to investigate the molecular mechanism underlying quantitative and functional changes of T in AD.
Objective: Little has been known on the effect of chronic glyphosate exposure on osteoarthritis (OA). The aim of this study was to investigate the association between glyphosate exposure and OA and to further investigate the different moderating effects of leisure time physical activity (LTPA) and body mass index (BMI) types on the association between glyphosate exposure and OA.
Methods: Cross-sectional data from 2540 participants in the 2015-2018 National Health and Nutrition Examination Survey (NHANES) were used to explore the association between glyphosate exposure and OA.
Objective: To report the efficacy and safety of combination therapy with selinexor, palbociclib, pembrolizumab, and umbilical cord blood NK cells for advanced hepatocellular carcinoma (HCC).Advanced HCC has a poor prognosis and limited effective treatment options. Exploring personalized combination treatment strategies is critically important for improving outcomes in patients with advanced HCC.
View Article and Find Full Text PDFBackground: The 2022-2023 mpox (monkeypox) outbreak has spread rapidly across multiple countries in the non-endemic region, mainly among men who have sex with men (MSM). In this study, we aimed to evaluate mpox's importation risk, border screening effectiveness and the risk of local outbreak in Chinese mainland.
Methods: We estimated the risk of mpox importation in Chinese mainland from April 14 to September 11, 2022 using the number of reported mpox cases during this multi-country outbreak from Global.
This study explores the room-temperature synthesis of porous materials and the immobilization of CO without the use of metals. The porous aromatic frameworks synthesized at room temperature retain the important functional group structure, and the abundance of carbon-chlorine bonds creates an excellent environment for imidazole linkage. Consequently, a catalyst conducive to the cycloaddition of carbon dioxide is obtained.
View Article and Find Full Text PDFJ Psychiatr Res
January 2024
Since the introduction of the concept of narcolepsy, there has been a proliferation of discussions about its association with psychiatry. To elucidate the causal role of narcolepsy in the three psychiatric disorders [i.e.
View Article and Find Full Text PDFTransition metal diborides represented by MoB have attracted widespread attention for their excellent acidic hydrogen evolution reaction (HER). Nevertheless, their electrocatalytic performance is generally unsatisfactory in high-pH electrolytes. Heterogeneous interface engineering is one of the most promising methods for optimizing the composition and structure of electrocatalysts, thereby greatly affecting their electrochemical performance.
View Article and Find Full Text PDFBackground: With the restriction of organophosphorus and other insecticides, pyrethroids are currently the second most-used group of insecticides worldwide due to their advantages such as effectiveness and low toxicity for mammalian. Animal studies and clinical case reports have documented associations between adverse health outcomesand exposure to pyrethroids. At present, the association between chronic pyrethroid exposure and osteoarthritis (OA) remains elusive.
View Article and Find Full Text PDFAngelman Syndrome (AS) is a severe cognitive disorder caused by loss of neuronal expression of the E3 ubiquitin ligase UBE3A. In an AS mouse model, we previously reported a deficit in brain-derived neurotrophic factor (BDNF) signaling, and set out to develop a therapeutic that would restore normal signaling. We demonstrate that CN2097, a peptidomimetic compound that binds postsynaptic density protein-95 (PSD-95), a TrkB associated scaffolding protein, mitigates deficits in PLC-CaMKII and PI3K/mTOR pathways to restore synaptic plasticity and learning.
View Article and Find Full Text PDFA hierarchical metal-organic framework, H-mMOF-1 (representing hierarchical medi-MOF-1), was successfully synthesized by the coassembly of MOF starting reagents and a triblock copolymer surfactant F127. The obtained H-mMOF-1 retained its microporous structure but also exhibited mesopores with a size range from 3 to 10 nm. The mesopores were able to accommodate protein Cyt with a loading capacity of 160 mg g.
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