Long-Life Quasi-Solid-State Lithium-Oxygen Battery Enabled by the Gel Polymer Electrolyte and Redox Moieties Anchored in the Cathode.

The practical development of Li-O batteries is often hindered by poor cycling stability, which arises from volatile liquid electrolytes, an unstable anode/electrolyte interface, and sluggish reaction kinetics related to LiO. In this study, we design a long-life quasi-solid-state Li-O battery by integrating a gel polymer electrolyte (GPE) with a tetramethylpiperidinyloxy (TEMPO) redox mediator anchored in a poly(2,2,6,6-tetramethylpiperidinyloxy-4-methacrylate) (PTMA) cathode. During cycling, the GPE stabilizes the lithium/electrolyte interface and retains the electrolyte, while the TEMPO moieties anchored in the PTMA cathode effectively enhance the catalytic selectivity for LiO formation and decomposition.

Metabolomic signature of sperm in men with obesity-associated asthenozoospermia.

Purpose: Obese men have a significantly increased risk of developing asthenozoospermia. Sperm motility is directly related to cellular energy supply and metabolic status. Sperm metabolomics research based on Gas chromatography-mass spectrometry (GC-MS) technology can provide useful information for the pathological mechanism, diagnosis, and treatment of obesity-associated asthenozoospermia.

Cordycepin alleviates diabetes mellitus-associated hepatic fibrosis by inhibiting SOX9-mediated Wnt/β-catenin signal axis.

Diabetes mellitus can induce liver injury and easily progress to liver fibrosis. However, there is still a lack of effective treatments for diabetes-induced hepatic fibrosis. Cordycepin (COR), a natural nucleoside derived from Cordyceps militaris, has demonstrated remarkable efficacy in treating metabolic diseases and providing hepatoprotective effects.

A novel signature constructed by cuproptosis-related RNA methylation regulators suggesting downregulation of YTHDC2 may induce cuproptosis resistance in colorectal cancer.

Background: A newly identified type of cell death due to intracellular copper accumulation is known as cuproptosis and RNA methylation is a post-transcriptional modification mechanism, both of which perform vital roles in the immune microenvironment of colorectal cancer (CRC), but the link between the two needs more research.

Methods: TCGA database provided RNA-seq data and details clinically of CRC samples. Cuproptosis-related RNA methylation regulators (CRRMRs) were identified by correlation analysis.

NMAAP1 regulated macrophage polarizion into M1 type through glycolysis stimulated with BCG.

Bacillus Calmette Guerin (BCG) perfusion is widely used as cancer adjuvant therapy, in which macrophages play an important role. Novel macrophage activated associated protein 1 (NMAAP1), upregulated after BCG's activation, was proved to promote macrophage polarization to the M1 type. We found that BCG could stimulate mice BMDM to the M1 type and kill tumor cells.

PDGFRA exhibits potential as an indicator of angiogenesis within the tumor microenvironment and is up-regulated in BLCA.

Bladder cancer (BLCA) is a common type of urogenital malignancy worldwide. The recurrence and metastasis of bladder cancer are closely related to angiogenesis, but the underlying mechanisms are unclear. In this study, we developed a method to predict survival outcomes among BLCA patients, which could be used to guide immunotherapy and chemotherapy.

Microbial signatures of neonatal bacterial meningitis from multiple body sites.

As a common central nervous system infection in newborns, neonatal bacterial meningitis (NBM) can seriously affect their health and growth. However, although metagenomic approaches are being applied in clinical diagnostic practice, there are some limitations for whole metagenome sequencing and amplicon sequencing in handling low microbial biomass samples. Through a newly developed ultra-sensitive metagenomic sequencing method named 2bRAD-M, we investigated the microbial signatures of central nervous system infections in neonates admitted to the neonatal intensive care unit.

Is glucocorticoid use associated with a higher clinical pregnancy rate of fertilization and embryo transfer? A meta-analysis.

Background: It has been reported that the use of glucocorticoids may be able to improve clinical pregnancy rates in patients receiving in vitro fertilization and embryo transfer (IVF-ET). The purpose of this study was to investigate the association between glucocorticoid use and clinical pregnancy rate in IVF-ET patients.

Methods: This study has been registered on the International Register of Prospective Systems Evaluation (PROSPERO) (ID: CRD42022375427).

Prognostic capacity of the systemic inflammation response index for functional outcome in patients with aneurysmal subarachnoid hemorrhage.

Objective: We aimed to investigate the relationship between systemic inflammatory response index (SIRI) and functional outcome after aneurysmal subarachnoid hemorrhage (aSAH).

Methods: A retrospective cohort study was performed involving all consecutive aSAH patients admitted to our institution. The modified Rankin Scale (mRS) score was performed to determine the functional outcomes of all patients at 3 months after aSAH.

Metabolomics profiling of seminal plasma in obesity-induced asthenozoospermia.

Background: Asthenozoospermia is one of the essential causes of male infertility, and its incidence is significantly higher in obese men. Due to its complex etiology and unknown pathomechanism, the diagnosis and treatment of obesity-induced asthenozoospermia is a prevalent problem in reproductive medicine.

Objective: This study aims to explore major differential metabolites and metabolic pathways in seminal plasma and pathological mechanisms for obesity-induced asthenozoospermia.

RuO-Incorporated CoO Nanoneedles Grown on Carbon Cloth as Binder-Free Integrated Cathodes for Tuning Favorable LiO Formation.

Developing ideal Li-O batteries (LOBs) requires the discharge product to have a large quantity, have large contact area with the cathode, and not passivate the porous surface after discharge, which put forward high requirement for the design of cathodes. Herein, combining the rational structural design and high activity catalyst selection, minor amounts of RuO-incorporated CoO nanoneedles grown on carbon cloth are successfully synthesized as binder-free integrated cathodes for LOBs. With this unique design, plenty of electron-ion-oxygen tri-phase reaction interface is created, the side reaction from carbon is isolated, and oxygen reduction reaction/oxygen evolution reaction (OER) kinetics are significantly facilitated.

Study on the preparation and properties of CaCO ultrafine powder derived from waste eggshell.

In this study, eggshell-derived CaCO ultrafine powder was prepared from waste eggshell with the method of omnidirectional planetary ball mill. The particle size distribution was measured by laser particle size analyzer. Then, the parameters of grinding kinetic equation of eggshell powder were obtained by software fitting, and the grinding model and characteristic equation of particle-size distribution of the eggshell-derived CaCO powder were discussed.

Morphological evaluation of the risk of posterior communicating artery aneurysm rupture: a mirror aneurysm model.

Objective: The aim of this study was to use morphological parameters of mirror posterior communicating artery (PCoA) aneurysms to evaluate aneurysm rupture risk.

Methods: The morphological parameters of 45 pairs of ruptured mirror PCoA aneurysms were analyzed. Conditional univariate and multivariate logistic regression of the following paired morphological parameters was performed: aneurysm with a daughter sac, aneurysm height, aneurysm width, neck width, internal carotid artery diameter, PCoA diameter, flow angle, PCoA angle, aspect ratio, bottleneck factor, size ratio, height/width ratio, fetal posterior cerebral artery, and aneurysm with height > width.

Prognostic significance of combined score of fibrinogen and neutrophil-lymphocyte ratio for functional outcome in patients with aneurysmal subarachnoid hemorrhage.

Objective: To explore the relationship between fibrinogen and neutrophil to lymphocyte ratio (F-NLR) score and functional outcomes after aneurysmal subarachnoid hemorrhage (aSAH).

Method: A retrospective study was conducted that involved all consecutive patients with aSAH admitted to our institution from March 2018 to October 2021. Factors, such as demographics, comorbidities, clinical characteristics, neuroradiological data, and laboratory parameters, were collected from institutional databases.

Strategies toward anode stabilization in nonaqueous alkali metal-oxygen batteries.

Alkali metal-O batteries exhibit ultra-high theoretical energy density which is even on par with fossil energy and are expected to become the next generation energy storage devices. However, to maintain the advantages of high energy density of alkali metal-O batteries, the reversibility of alkali metal anodes with high capacity is of vital importance. But the alkali metal anode with high chemical activity often faces a variety of challenges, including various side reactions, dendrite formation and volume expansion.

Architectural Narrative Shapes Brain Activities Underlying Approach-Avoidance Response: A Case Study of the Stadium.

Each great architecture tells a story to make its space meaningful. What the stadium tells matters how the individual interacts with it. The potent influence of narrative in shaping our cognitive processing has been revealed and widely used.

Additive-Assisted Hydrophobic Li -Solvated Structure for Stabilizing Dual Electrode Electrolyte Interphases through Suppressing LiPF Hydrolysis.

Lithium-metal batteries have attracted much attention due to their high energy density. However, the hydrolysis of LiPF leads to uncontrollable Li dendrites growth and fast capacity fading. Herein, a hydrophobic Li -solvated structure is designed by inducing the hexafluoroisopropyl acrylate into the electrolyte system.

Predictors of complete recovery of oculomotor nerve palsy induced by posterior communicating artery aneurysms in patients aged eighteen to sixty.

Objective: To explore prognostic factors of complete recovery of oculomotor nerve palsy (ONP) induced by posterior communicating artery aneurysm (PcomAA).

Method: PcomAA patients aged 18-60 years combined with ONP who underwent surgical clipping or endovascular embolization at our institution between January 2014 and January 2020 were enrolled. Characteristics included maximum diameter of aneurysm, width of aneurysm, subarachnoid hemorrhage (SAH), duration of ONP, age, sex, ONP type, treatment method were compared.

Li O Formation Electrochemistry and Its Influence on Oxygen Reduction/Evolution Reaction Kinetics in Aprotic Li-O Batteries.

Aprotic Li-O batteries are regarded as the most promising technology to resolve the energy crisis in the near future because of its high theoretical specific energy. The key electrochemistry of a nonaqueous Li-O battery highly relies on the formation of Li O during discharge and its reversible decomposition during charge. The properties of Li O and its formation mechanisms are of high significance in influencing the battery performance.

The role of HIF-1α in BCG-stimulated macrophages polarization and their tumoricidal effects in vitro.

BCG is widely used for cancer treatment, where macrophages play an important role. However, the mechanism of BCG affecting macrophages remains poorly understood. In this study, we used BCG to stimulate myeloid-derived macrophages lacking HIF-1α, the levels of TNF-α, IL-1β, CD86 of macrophages and their effects on the growth of tumor cells MCA207 and B16-F10 were detected.

Inflammation-associated factors for predicting in-hospital mortality in patients with COVID-19.

The aim is to explore the relation between inflammation-associated factors and in-hospital mortality and investigate which factor is an independent predictor of in-hospital death in patients with coronavirus disease-2019. This study included patients with coronavirus disease-2019, who were hospitalized between February 9, 2020, and March 30, 2020. Univariate Cox regression analysis and least absolute shrinkage and selection operator regression (LASSO) were used to select variables.

Gradient Solid Electrolyte Interphase and Lithium-Ion Solvation Regulated by Bisfluoroacetamide for Stable Lithium Metal Batteries.

The structures and components of solid electrolyte interphase (SEI) are extremely important to influence the performance of full cells, which is determined by the formulation of electrolyte used. However, it is still challenging to control the formation of high-quality SEI from structures to components. Herein, we designed bisfluoroacetamide (BFA) as the electrolyte additive for the construction of a gradient solid electrolyte interphase (SEI) structure that consists of a lithophilic surface with C-F bonds to uniformly capture Li ions and a LiF-rich bottom layer to guide the rapid transportation of Li ions, endowing the homogeneous deposition of Li ions.

Development and validation of a nomogram using on admission routine laboratory parameters to predict in-hospital survival of patients with COVID-19.

To develop and validate a nomogram using on admission data to predict in-hospital survival probabilities of coronavirus disease 2019 (COVID-19) patients. We analyzed 855 COVID-19 patients with 52 variables. The least absolute shrinkage and selection operator regression and multivariate Cox analyses were used to screen significant factors associated with in-hospital mortality.

The novel target：exosoms derived from M2 macrophage.

More and more exosome-based therapeutics are being developed with advances in nanotechnology and precision medicine. Exosome is a kind of tiny vesicles with a bilayer of phospholipids, which can transfer biological macromolecules to recipients to influence the biological process. M2 macrophages are closely related to the occurrence and development of serious diseases such as tumor.