Publications by authors named "Yuya Uehara"
Background: Examining human coding and non-coding RNAs present in skin surface lipids (SSL-RNAs) offers a promising approach to understanding the physiological state of the skin. Benralizumab treatment can reduce exacerbations and improve symptom control and quality of life in patients with severe eosinophilic asthma. Although this treatment effectively depletes peripheral blood eosinophils, the impact of benralizumab on SSL-RNA remains completely unknown.
View Article and Find Full Text PDFImpact of Dupilumab on Skin Surface Lipid-RNA Profile in Severe Asthmatic Patients.
Curr Issues Mol Biol
October 2024
The analysis of skin surface lipid-RNAs (SSL-RNAs) provides a non-invasive method for understanding the molecular pathology of atopic dermatitis (AD), but its relevance to asthma remains uncertain. Although dupilumab, a biologic drug approved for both asthma and AD, has shown efficacy in improving symptoms for both conditions, its impact on SSL-RNAs is unclear. This study aimed to investigate the impact of dupilumab treatment on SSL-RNA profiles in patients with severe asthma.
View Article and Find Full Text PDFAcute myeloid leukemia (AML) cells are highly dependent on oxidative phosphorylation and the mitochondrial dynamics regulated by fusion-related genes MFN1, MFN2, and OPA1 and fission-related genes DNM1L and MFF. An analysis of previously published gene expression datasets showed that high expression of MFF was significantly associated with poor prognosis in patients with AML. Based on this finding, we investigated the impact of mitochondrial dynamics in AML.
View Article and Find Full Text PDFmRNAs in skin surface lipids unveiled atopic dermatitis at 1 month.
J Eur Acad Dermatol Venereol
July 2023
Background: The molecular pathogenesis of atopic dermatitis (AD), presenting skin barrier dysfunction and abnormal inflammations around 1-2 months, is unreported.
Objective: We aimed to examine the molecular pathogenesis of very early-onset AD by skin surface lipid-RNA (SSL-RNA) using a non-invasive technology in infants aged 1 and 2 months from a prospective cohort.
Methods: We collected sebum by oil-blotting film of infants aged 1 and 2 months and analysed RNAs in their sebum.
Article Synopsis
- Non-invasive collection of mRNA from skin surface lipids (SSLs) offers insights into skin health and diseases by analyzing the genetic material found in the skin's natural oils.
- Research shows that human mRNAs are protected in SSLs, particularly from sebaceous glands, epidermis, and hair follicles, making them viable for study.
- In patients with atopic dermatitis, there are notable changes in gene expression related to inflammation and skin function, highlighting the potential of SSL-RNA analysis for better understanding skin conditions.
Article Synopsis
- Parkinson's disease (PD) is a progressive condition that affects motor and non-motor functions, with associated skin disorders and changes in sebum production.
- A new method called SSL-RNAs, which analyzes RNA from skin surface lipids non-invasively, has been developed to study gene expression related to PD.
- In research involving two cohorts, over 100 genes were identified as differentially expressed in PD patients compared to controls, and machine learning techniques were effective in distinguishing PD patients, suggesting this approach could aid in early diagnosis.
Article Synopsis
- Sensitive skin is a condition marked by heightened sensitivity to various environmental factors, and while its causes aren't fully understood, it is diagnosed through subjective symptoms and tests, though objective measures like biomarkers are still needed.
- This study analyzed skin surface lipids from people reporting sensitive and non-sensitive skin to compare gene expression profiles, identifying 417 genes that differ between the two groups, with notable findings in immune response pathways and olfactory receptor genes.
- The findings suggest that olfactory receptor gene expression could serve as an indicator of sensitive skin, as the study demonstrated a strong ability to differentiate between subjective skin sensitivity levels based on these gene profiles.
In March, 2011, large amounts of radioactive materials were released from the Fukushima Daiichi nuclear power plant after the nuclear accident. Especially, for humans, internal exposure to ¹³⁷Cs and ⁹⁰Sr radionuclides presents very high risks because of their very long physical half-lives (¹³⁷Cs: 30.2 years, ⁹⁰Sr: 28.
View Article and Find Full Text PDF[A case of mediastinal pancreatic pseudocyst accompanied by pancreatic pleural effusion].
Nihon Shokakibyo Gakkai Zasshi
April 2012
A 62-year-old man was admitted with dyspnea. Computed tomography (CT) revealed left massive pleural effusion and a cystic lesion in the posterior mediastinal compartment extending to the pancreatic head via the esophageal hiatus. The pleural effusion had a high amylase content.
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