Publications by authors named "Yuya Nogi"

Article Synopsis
  • This study examines the role of tertiary lymphoid structures (TLSs) in esophageal cancer (EC) and their potential to improve patient outcomes. //! -
  • Researchers analyzed 316 surgical specimens to assess the density and maturity of TLSs, finding that higher density was linked to earlier cancer stages, fewer invasions, better nutrition indicators, and longer survival. //! -
  • In a follow-up study involving 34 patients receiving anti-PD-1 therapy, higher TLS density correlated with better response to treatment and increased survival rates, highlighting the significance of TLS characteristics in cancer prognosis. !*
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Background: Peri- or intra-tumor lymphangiogenesis is induced in several types of cancer. However, the significance of peritumoral lymphatic vessels (LVs) in esophageal cancer (EC) remains to be clarified.

Methods: This study included 162 eligible EC patients with or without neoadjuvant chemotherapy (NAC).

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The patient was a 63-year-old man with a chief complaint. Upper endoscopic examination revealed a semicircular type 2 lesion, sized 24-28 cm, on the incisor teeth and a 3 cm sized elevated lesion directly above the EGJ. When biopsy was performed, squamous cell carcinoma(SCC)was detected.

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A 72-year-old man underwent endoscopic submucosal dissection for early gastric cancer at antrum in July 2015. The histopathological examination revealed an adenocarcinoma invading the deep submucosal layer(SM2)with lymphatic invasion, consistent with the diagnosis of non-curative resection. Additional surgery was recommended, and he underwent laparoscopic distal gastrectomy in August 2015.

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A 63-year-old woman had recurrences of metastatic rectal cancer in the lung, peritoneum, and ovary. Regorafenib was administered at 160mg/day as third-line chemotherapy. The patient developed Grade(Gr)3 hand-foot syndrome(HFS) and Gr 2 rash, but the abdominal distension and pain were relieved by the 1st course.

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