Publications by authors named "Yuya Kimijima"
Article Synopsis
- This study analyzed changes in treatment patterns for Japanese patients with resectable gastric cancer from 2008 to 2022, focusing on adjuvant and recurrent therapy.
- In the adjuvant cohort, the use of S-1 decreased as new regimens were adopted, with S-1 making up 65% of treatments by 2019-2022, compared to 95.7% earlier.
- The recurrent cohort showed common first-line treatments like paclitaxel plus ramucirumab and S-1 combinations, aligning with Japanese Gastric Cancer Association guidelines.
Nitric oxide (NO) is implicated in neuronal cell survival. However, excessive NO production mediates neuronal cell death, in part via mitochondrial dysfunction. Here, we report that the mitochondrial ubiquitin ligase, MITOL, protects neuronal cells from mitochondrial damage caused by accumulation of S-nitrosylated microtubule-associated protein 1B-light chain 1 (LC1).
View Article and Find Full Text PDF