Publications by authors named "Yuya Iwahashi"

Background: We compare the oncological outcomes and health-related quality of life (HRQOL) in men with high-risk prostate cancer after robot-assisted radical prostatectomy (RARP) versus that after high-dose-rate brachytherapy + external beam radiotherapy + hormone therapy (hereafter: "HDR+").

Methods: We included 233 men who underwent RARP and 179 men who underwent HDR+ for high-risk prostate cancer at our hospital. We investigated the following oncologic outcomes: time to biochemical recurrence, time to development of castration-resistant prostate cancer (CRPC), cancer-specific survival, and overall survival.

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Background: We investigated potential disparities in health-related quality of life, particularly concerning urinary function, between patients with preserved and those with impaired sexual function after robot-assisted radical prostatectomy (RARP).

Materials And Methods: Between December 2012 and April 2020, 704 men underwent RARP in our hospital. This study included 155 patients with a preoperative 5-item International Index of Erectile Function (IIEF-5) of ≥12 points and an assessable IIEF-5 at 12 months postoperatively.

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Purpose: Stone extraction is an important treatment option when performing flexible ureteroscopic lithotripsy (f-URSL) for upper urinary stones. We used a f-URSL simulator model to investigate surgical factors affecting the efficacy of stone extraction with the one-surgeon basketing technique.

Materials And Methods: This simulator-based study involved eight urologists and eight residents.

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Article Synopsis
  • Cisplatin is a commonly used chemotherapy drug for solid tumors but can cause acute kidney injury (AKI), which currently has no effective treatment.
  • Thrombomodulin (TM) shows promise in reducing nephrotoxicity caused by cisplatin, as it lowers harmful substances like blood urea nitrogen and serum creatinine levels in mice.
  • TM works by decreasing oxidative stress and ER stress in kidney cells, indicating its potential as a protective agent against cisplatin-induced kidney damage.
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Ureteroscopic lithotripsy for impacted stones is challenging, but it is important to predict impacted stones preoperatively. Hydronephrosis, which is evaluated by a grading system, is often apparent in impacted stones. However, the currently used grading system is a qualitative evaluation.

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Introduction: We aimed to investigate the detection rate of causative organisms in stone-related pyelonephritis and to compare their distribution according to patient backgrounds.

Methods: We retrospectively identified patients with stone-related pyelonephritis. Clinical data were collected between November 2012 and August 2020 at Wakayama Medical University Hospital, including on patient backgrounds and causative organisms.

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A 44-year-old man with osteogenesis imperfecta presented with left renal colic. Non-contrast computed tomography revealed a stone (10×9 mm) in the left upper ureter. Ureteroscopic lithotripsy was performed twice and stone-free status was achieved.

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Article Synopsis
  • Researchers investigated how different laser pulse modes affect temperature changes during laser lithotripsy using thermography.
  • An artificial kidney model was tested with four modes: short pulse, long pulse, virtual basket, and Moses mode, focusing on temperature areas above 43°C over 60 seconds.
  • The study found that the long pulse and Moses modes created larger high-temperature areas compared to the short pulse and virtual basket modes, which could help in reducing thermal injuries during renal surgeries.
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This study aims to evaluate changes in irrigation fluid temperatures during laser activation by using thermography, with comparison between Moses mode (MM) and virtual basket mode (VBM). Experiments were performed using an unroofed pyelocaliceal model. The laser was fired for 60 seconds at 0.

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Impacted stones typically make it difficult to perform ureteroscopic lithotripsy (URSL), so it is useful to preoperatively predict such impaction. We focused on CT attenuation values of the ureter above and below the stone ('HU above' and 'HU below') and calculated their ratio (HAB ratio; HU above/HU below ratio). The aim was to investigate whether HAB ratio could predict impacted stones preoperatively.

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Evidence of the prognostic value of pretreatment systemic immune-inflammation index (SII) after radical cystectomy (RC) for bladder cancer is limited. This study aims to assess the association between preoperative SII and prognosis after RC for bladder cancer. In this multicenter retrospective study, we calculated preoperative SII as well as the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in 237 patients who underwent RC for bladder cancer between March 2009 and March 2018.

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Introduction: Prostate sarcoma is an extremely rare disease with a poor prognosis. Undifferentiated pleomorphic sarcoma has never been described in the prostate. A 27-year-old man complained of frequent urination and dysuria for several years.

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This study aims to evaluate the influence of myosteatosis on survival of patients after radical cystectomy (RC) for bladder cancer. We retrospectively identified 230 patients who underwent RC for bladder cancer at our three institutions between 2009 and 2018. Digitized free-hand outlines of the left and right psoas muscles were made on axial non-contrast computed tomography images at level L3.

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The association between mean stone density (MSD) and ureteroscopic lithotripsy outcome remains controversial. MSD automatically measured by 3D images of stones (3D-MSD) was recently reported to be more useful than manual measuring methods for predicting outcomes of shock-wave lithotripsy. This study aims to investigate whether 3D-MSD can predict ureteroscopic lithotripsy outcome.

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Kidney stones are a major public health concern with continuously increasing worldwide prevalence. Shock wave lithotripsy (SWL) is the first line treatment choice for upper urinary tract calculi with ureteroscopy and has advantages of safety and noninvasiveness, but the treatment success rate of SWL is lower than that of other therapies. It is therefore important to identify predictive factors for SWL outcome and select a suitable treatment choice for patients with upper urinary tract calculi.

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Article Synopsis
  • The study aimed to evaluate how effective three-dimensional images of kidney stones are in predicting the success of shock wave lithotripsy by measuring mean stone density.
  • Researchers analyzed data from 239 patients, using a high-functional viewer to measure stone density and compared it to traditional methods; results showed that 48.5% of treatments were successful.
  • Findings indicated that mean stone density measured through three-dimensional images was a better predictor of treatment outcomes than other methods, highlighting its potential for enhancing clinical predictions.
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