Association of watching sports games with subsequent health and well-being among adults in Japan: An outcome-wide longitudinal approach.

Objective: Although the health benefits of playing sports are well-known, the association between watching sports and health is not well understood. We examined the longitudinal association of watching sports with 20 different health and well-being outcomes.

Methods: Three-wave cohort data from 6327 adults (4851 workers) in the Meiji Yasuda LifeStyle study were used to draw causal inferences.

Associations of Working From Home Frequency With Accelerometer-Measured Physical Activity and Sedentary Behavior in Japanese White-Collar Workers: A Cross-Sectional Analysis of the Meiji Yasuda LifeStyle Study.

Background: The association of working from home (WFH) with physical activity (PA) and sedentary behavior (SB) has been explored; however, this association during periods without stringent measures to combat coronavirus disease 2019 is undercharacterized. Particularly, few studies have evaluated the potential effect modification on its associations. Therefore, this study aimed to investigate the associations of WFH frequency with accelerometer-measured PA and SB, along with its effect modifiers, among Japanese white-collar workers during the later pandemic period.

Cross-sectional study of the optimal types of physical exercise for cognitive function in older Japanese adults.

Aim: This study aimed to determine whether practicing coordination exercises, compared with other physical exercise types, is associated with better cognitive function in older Japanese adults.

Methods: This cross-sectional study used data from a health checkup project carried out from 2015 to 2019 among older adults living in Kasama City, Ibaraki Prefecture, Japan. Data from 569 participants (mean age 74.

Clinical features and prognosis of conjunctival melanoma in Japanese patients.

Purpose: To evaluate the clinical features and prognosis of conjunctival melanoma in Japanese patients.

Study Design: Retrospective observational case series.

Methods: Twenty patients (8 men and 12 women) diagnosed with conjunctival melanoma at a singlehospital between 2003 and 2017 were analyzed.

Changes in Accelerometer-measured Physical Activity and Sedentary Behavior From Before to After COVID-19 Outbreak in Workers.

Background: The novel coronavirus disease 2019 (COVID-19) pandemic may have reduced opportunities for engaging in physical activity (PA) and increased sedentary behavior (SB) among workers. However, most previous studies used self-reported assessments. This study aimed to examine the changes in accelerometer-measured PA and SB from before to after COVID-19 outbreak among Japanese workers.

Association of 24-h movement behaviors with phase angle in community-dwelling older adults: a compositional data analysis.

Background: Phase angle (PhA) is an indicator of cellular conditions. Recent studies have suggested that PhA supports healthy aging. Identifying modifiable lifestyle factors for PhA is important.

Rhodopsin-positive cell production by intravitreal injection of small molecule compounds in mouse models of retinal degeneration.

We aimed to verify whether the intravitreal injection of small molecule compounds alone can create photoreceptor cells in mouse models of retinal degeneration. Primary cultured mouse Müller cells were stimulated in vitro with combinations of candidate compounds and the rhodopsin expression was measured on day 7 using polymerase chain reaction and immunostaining. We used 6-week-old N-methyl-N-nitrosourea-treated and 4-week-old rd10 mice as representative in vivo models of retinal degeneration.

Impact of exercising alone and exercising with others on the risk of cognitive impairment among older Japanese adults.

Purpose: This longitudinal study investigates the influence of the stratified frequency of exercising alone and exercising with others on the prevention of cognitive impairment among older Japanese adults.

Methods: This four-year follow-up study targeted 4,358 individuals (mean age: 76.9 ± 5.

Acceptable walking and cycling distances and functional disability and mortality in older Japanese adults: An 8-year follow-up study.

We prospectively investigated the association between acceptable travel distances (i.e., walking and cycling) and the incidence of functional disability and mortality among older Japanese adults.

Frail Older Adults without Occupational Dysfunction Maintain Good Subjective Well-Being: A Cross-Sectional Study.

The purpose of this cross-sectional study was to clarify the relationship between frailty/occupational dysfunction (OD), both with and without, and subjective well-being among community-dwelling older adults. A total of 2308 (average age: 72.2 ± 5.

The association of the Japan Science and Technology Agency Index of Competence with physical and cognitive function in community-dwelling older adults.

Aim: To investigate the association of the Japan Science and Technology Agency Index of Competence with physical and cognitive functions in community-dwelling older adults.

Methods: This study used the data of 565 community-dwelling adults aged ≥65 years (mean age: 74.3 ± 5.

Successful treatment with lenvatinib in a patient with thymic carcinoma presenting with cardiac tamponade: a case report and review of literature.

Thymic carcinoma (TC) presenting with cardiac tamponade has a poor prognosis because of the difficulty in controlling malignant pericardial effusion using conventional chemotherapy. Lenvatinib, a multitargeted kinase inhibitor of vascular endothelial growth factor receptor and other kinases, has recently been proven effective against TC. As the inhibition of vascular endothelial growth factor signaling is effective in malignant pericardial effusion, lenvatinib may also be effective in TC presenting with cardiac tamponade.

Physical Activity Intensity and Suspected Dementia in Older Japanese Adults: A Dose-Response Analysis Based on an 8-Year Longitudinal Study.

Background: Moderate- to vigorous-intensity physical activity (PA) may reduce the risk of dementia; however, few studies have examined the effects of PA intensity on dementia risk.

Objective: To prospectively examine the dose-response relationship of PA intensity with the incidence of suspected dementia in community-dwelling older adults.

Methods: We conducted a baseline mail survey with an 8-year follow-up of 3,722 older adults in Japan.

Association of domain-specific physical activity and sedentary behavior with cardiometabolic health among office workers.

Objective: Previous studies have reported opposite effects of occupational or non-occupational physical activity (PA) and sedentary behavior (SB) on health outcomes. However, no study has investigated the relationship between domain-specific movement behaviors and cardiometabolic health (CMH) among office workers, considering the compositional nature of time-use data. We investigated the associations of accelerometer-measured PA and SB for each domain (working time, non-working time on workday, and non-workday) with CMH indicators among office workers, using compositional data analysis.

Electrophilic Spirocyclization of a 2-Biphenylacetylene via Conformational Fixing within a Hollow-Cage Host.

A 2-biphenylacetylene was fixed into a specific conformation within the confined cavity of a hollow cage, where it underwent a regioselective spirocyclization in the presence of an electrophile. A 5-endo-dig cyclization proceeded selectively in the cage, which stands in sharp contrast to the 6-endo-dig cyclization that normally occurs in common organic media. The folded conformation adopted by the substrate within the cage was examined by H NMR spectroscopy and X-ray crystallographic analysis.

Pre-frailty associated with traffic crashes in Japanese community-dwelling older drivers.

Frailty might be useful to identify older drivers who are at risk for traffic crashes. We aim to examine the association between pre-frailty/frailty defined by the Kihon Checklist (KCL) and the involvement of traffic crashes and clarify whether some domains of the KCL are associated with traffic crashes. This cross-sectional study analyzed data from 2,208 Japanese community-dwelling older drivers aged ≥ 65 years in Kasama City, who participated in our postal survey in November 2019.

Combined effect of daily physical activity and social relationships on sleep disorder among older adults: cross-sectional and longitudinal study based on data from the Kasama study.

Background: This study investigated whether daily physical activity of older adults, combined with social relationships, is associated with the risk of sleep disorder. Further, it determined whether a high level of one variable with a low level of the other, leads to a significantly lower risk of sleep disorder than low levels of both.

Methods: The sample comprised 1339 community-dwelling older Japanese adults: 988 in Study 1 and 351 in Study 2.

A case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndrome.

Paraneoplastic neurological syndrome (PNS) is associated with malignancies, such as small-cell lung cancer. However, patients with non-small cell lung cancer (NSCLC) rarely develop PNS. We herein report a 72-year-old man with NSCLC who developed disturbance of consciousness on the day of initiation of treatment with an immune checkpoint inhibitor.

Mediating role of instrumental activities of daily living ability on cognitive function of older adults living alone: A 4-year longitudinal study from the Kasama study.

The aim of this study was to clarify the effect of living alone on the cognitive function of older people and the mediating effect of instrumental activities of daily living (IADL) ability.The data for a final sample of 3276 participants aged 65 years and above who did not require long-term care at the baseline were used from a 4-year prospective cohort study conducted in Kasama City, Japan. Demographic data including age, sex, and depression at baseline were used as covariates.

Association between Occupational Dysfunction and Social Isolation in Japanese Older Adults: A Cross-Sectional Study.

We clarified the relationship between occupational dysfunction and social isolation among community-dwelling adults. We used a self-administered questionnaire with a cross-sectional study for 2879 independently living older adults in Kasama City, Japan. Participants responded to a self-reported questionnaire in November 2019.

Incomplete pseudo-Meigs' syndrome caused by endometrial ovarian cyst: A case report.

A 63-year-old female was admitted to our hospital with history of persistent dyspnea. Right pleural effusion and ovarian tumor were discovered, but here were no significant findings on thoracoscopy under local anesthesia. The pleural effusion was suspected to be secondary to Meigs' syndrome, and a diagnosis of endometriotic ovarian cyst was made.

Successful Re-administration of Atezolizumab for a Non-small-cell Lung Cancer Patient after Cardiac Tamponade Development as a Manifestation of Pseudo-progression Induced by Combination Treatment with Atezolizumab and Cytotoxic Chemotherapy.

Pseudo-progression is a phenomenon induced by treatment with immune checkpoint inhibitors and is characterized by an increase in tumor size or the appearance of new lesions, followed by tumor regression. However, life-threatening conditions, such as cardiac tamponade, can develop in such patients. We herein report on a 69-year-old man with lung adenocarcinoma who developed cardiac tamponade as a manifestation of pseudo-progression induced by treatment with atezolizumab combined with cytotoxic chemotherapy.

Associations between exercising in a group and physical and cognitive functions in community-dwelling older adults: a cross-sectional study using data from the Kasama Study.

[Purpose] To examine the associations of exercise habits, particularly exercising in a group, with physical and cognitive functions in community-dwelling older adults. [Participants and Methods] A total of 615 older adults participated in this cross-sectional study. We conducted three physical performance tests (grip strength, five times sit-to-stand, and 5-meter walk tests) and the Five-Cog test (attention, memory, visuospatial, language, and reasoning).

Translational Research in Retinopathy of Prematurity: From Bedside to Bench and Back Again.

Retinopathy of prematurity (ROP), a vascular proliferative disease affecting preterm infants, is a leading cause of childhood blindness. Various studies have investigated the pathogenesis of ROP. Clinical experience indicates that oxygen levels are strongly correlated with ROP development, which led to the development of oxygen-induced retinopathy (OIR) as an animal model of ROP.