A pilot clinical risk model to predict polymyxin-induced nephrotoxicity: a real-world, retrospective cohort study.

Objectives: Polymyxin-induced nephrotoxicity (PIN) is a major safety concern and challenge in clinical practice, which limits the clinical use of polymyxins. This study aims to investigate the risk factors and to develop a scoring tool for the early prediction of PIN.

Methods: Data on critically ill patients who received intravenous polymyxin B or colistin sulfate for over 24 h were collected.

TOM40 mediates the effect of TSPO on postpartum depression partially through regulating calcium homeostasis in microglia.

Aims: To assess the effect of the translocator protein 18 kDa (TSPO) on postpartum depression and explore its mechanism.

Methods: Postpartum depression (PPD) mouse model was established, and flow cytometry, immunofluorescence, Western blot analysis, real-time quantitative PCR, adeno-associated virus (AAV), co-immunoprecipitation-mass spectrometry and immunofluorescence co-staining were used to detect the effect of TSPO ligand ZBD-2 on PPD mice.

Results: ZBD-2 inhibits the overactivation of microglia in the hippocampus and amygdala of PPD model mice.

Pd-IHept-Catalyzed Ring-Opening of -Difluorocyclopropanes with Malonates Via Selective C-C Bond Cleavage: Synthesis of Monofluoroalkenes.

Monofluoroalkene scaffolds are frequently found in various functional molecules. Herein, we report a Pd-IHept-catalyzed (NHC = N-heterocyclic carbene) defluorinative functionalization approach for the synthesis of monofluoroalkenes from -difluorocyclopropanes and malonates. The flexible yet sterically hindered ,'-bis(2,6-di(4-heptyl)phenyl)imidazol-2-ylidene ligand plays a key role in ensuring the high reaction efficiency.

Nine-fold symmetry of centriole: The joint efforts of its core proteins.

The centriole is a widely conserved organelle required for the assembly of centrosomes, cilia, and flagella. Its striking feature - the nine-fold symmetrical structure, was discovered over 70 years ago by transmission electron microscopy, and since elaborated mostly by cryo-electron microscopy and super-resolution microscopy. Here, we review the discoveries that led to the current understanding of how the nine-fold symmetrical structure is built.

Schrödinger principal-component analysis: On the duality between principal-component analysis and the Schrödinger equation.

Principal component analysis (PCA) has been applied to analyze random fields in various scientific disciplines. However, the explainability of PCA remains elusive unless strong domain-specific knowledge is available. This paper provides a theoretical framework that builds a duality between the PCA eigenmodes of a random field and eigenstates of a Schrödinger equation.

Superresolution characterization of core centriole architecture.

The centrosome is the main microtubule-organizing center in animal cells. It comprises of two centrioles and the surrounding pericentriolar material. Protein organization at the outer layer of the centriole and outward has been studied extensively; however, an overall picture of the protein architecture at the centriole core has been missing.

Research of the three-dimensional tracking and registration method based on multiobjective constraints in an AR system.

To match the virtual image and actual environment in an augmented reality (AR) system, it is necessary to complete the task of three-dimensional (3D) tracking registration. This paper proposes a new method for 3D tracking registration. Previous methods extract feature points in images to realize tracking registration.

[Efficacy of acupuncture-moxibustion periodic therapy on follicular maldevelopment differentiated as spleen and kidney deficiency].

Objective: To observe the clinical efficacy of acupuncture and moxibustion periodic therapy on folli-cular maldevelopment differentiated as spleen and kidney deficiency.

Methods: Sixty patients of follicular maldevelopment differentiated as spleen and kidney deficiency were randomized as an observation group and a control group, 30 cases in each one. The conventional acupuncture-moxibustion therapy was used in the control group and the acupuncture-moxibustion periodic therapy was applied to the observation group.