BEOL Three-Dimensional Stackable Oxide Semiconductor CMOS Inverter with a High Voltage Gain of 233 at Cryogenic Temperatures.

Targeting high-performance computing at cryogenic temperatures, we report back-end-of-line (BEOL)-compatible p-type Te-TeO field effect transistors (FETs) deposited using a sputtering method that is cost-effective, large-scale manufacturable, and highly controllable. Combined with the indium tin oxide channel n-FETs employing a common gate and HfO gate dielectric, BEOL three-dimensional stackable oxide semiconductor complementary metal oxide semiconductor (CMOS) inverters were further realized, demonstrating excellent threshold voltage matching, with a high voltage gain of 132 with a 2 V supply voltage () at room temperature. At cryogenic temperatures, the CMOS inverter exhibits significantly enhanced performance, achieving a voltage gain of 233 at a of 2 V with a wide noise margin of 86%.

Establishment and validation of a prognostic model for idiopathic pulmonary fibrosis based on mitochondrial-related genes.

Background: The prognosis for patients diagnosed with idiopathic pulmonary fibrosis (IPF) is exceedingly grim, and there are currently no pharmacological interventions available that effectively reduce mortality rates. Emerging evidence underscores the intimate connection between mitochondrial dysfunction and the onset and advancement of IPF. However, there remains a scarcity of prognostic models for assessing the risk associated with mitochondrial-related genes in IPF.

Detection of human brain cancers using genomic and immune cell characterization of cerebrospinal fluid through CSF-BAM.

Unlabelled: Patients who have radiographically detectable lesions in their brain or other symptoms compatible with brain tumors pose challenges for diagnosis. The only definitive way to diagnose such patients is through brain biopsy, an obviously invasive and dangerous procedure. Here we present a new workflow termed "CSF-BAM" that simultaneously identifies cell or T cell receptor rearrangements, neuploidy, and using PCR-mediated amplification of both strands of the DNA from CSF samples.

Bottom-up approaches to prepare ultrathin TiO nanosheets.

Atomically thin two-dimensional (2D) materials are promising platforms to explore the unusual physical and chemical properties in surface chemistry, various catalysis, and devices. Most 2D materials derive from inherently layer-structured compounds through top-down exfoliation, but it is usually challenging to directly prepare ultrathin nanosheets of non-layered materials. TiO contains at least 8 non-layered polymorphs, and some of them have found wide applications in heterogeneous catalysis, photocatalysis, solar cells, lithium-ion batteries, In this review, we summarize typical bottom-up wet-chemistry synthetic systems of atomically thin TiO nanosheets.

Giant Cysticercosis of the Right Kidney: A Case Report.

Cysticercosis, although reported in several parts of the body, especially the liver, lesions occurring in the kidney are particularly rare. We report a 58-year-old female patient with intermittent epigastric pain, who was found to have a huge occupancy of the right kidney on computed tomography (CT) and magnetic resonance imaging (MRI), which was confirmed to have a predominantly cystic component, with no clear enhancement on CT images after injection of contrast medium, and significant enhancement of the peritoneum and septum visible on MRI. This case reports a case and its rarity of cysticercosis occurring in the kidney.

Transcriptome-wide mapping of internal mRNA N-methylguanosine in sporulated and unsporulated oocysts of Eimeria tenella reveals stage-specific signatures.

Background: Growing evidence indicates that N-methylguanosine (mG) modification plays critical roles in epigenetic regulation. However, no data regarding mG modification are currently available in Eimeria tenella, a highly virulent species causing coccidiosis in chickens.

Methods: In the present study, we explore the distribution of internal messenger RNA (mRNA) mG modification in sporulated and unsporulated oocysts of E.

Synthesis of nitrogen-doped carbon dot/tin disulfide nanosheet composite electro-catalysts for dye-sensitized solar cells.

Nitrogen-doped carbon dots (N-CDs) and vertically-grown tin disulfide (SnS) nanosheets are synthesized via hydrothermal method and chemical vapor deposition technique, respectively. The SnSnanosheets are directly fabricated on flexible carbon cloth (CC), and then their basal planes are decorated with N-CDs. The as-prepared composite electrodes are used as the counter electrode for the application in dye-sensitized solar cells (DSSCs).

Increases in PM levels in Houston are associated with a highly recirculating sea breeze.

Local land-sea breezes play an important role in coastal air quality because they circulate air between coastal/urban and marine areas, potentially causing the accumulation of pollutants. This has been observed for the secondary photochemical pollutant ozone. However, particulate matter (PM) also warrants investigation.

ReaL-MGE is a tool for enhanced multiplex genome engineering and application to malonyl-CoA anabolism.

The complexities encountered in microbial metabolic engineering continue to elude prediction and design. Unravelling these complexities requires strategies that go beyond conventional genetics. Using multiplex mutagenesis with double stranded (ds) DNA, we extend the multiplex repertoire previously pioneered using single strand (ss) oligonucleotides.

Generation of antibody-drug conjugates by proximity-driven acyl transfer and sortase-mediated ligation.

We report a sortase-based site-specific antibody-drug conjugation strategy, which involves an affinity peptide-directed acyl transfer reaction and sortase-mediated peptide ligation. Through the affinity peptide-mediated acyl transfer reaction, an LPXTG-containing peptide is conjugated to a specific Lys side chain of an antibody. Under the assistance of sortase, a protein drug bearing a GG motif reacts specifically with the LPXTG moiety to produce an antibody-drug conjugate.

Effects of major air pollutants on cognitive function in middle-aged and elderly adults: Panel data evidence from China Health and Retirement Longitudinal Study.

Background: Although numerous studies have discussed about the impact of air pollution on cognitive function, a consensus has yet to be reached, necessitating further exploration of their relationship. The aim of this study is to reveal the effects of major air pollutants on cognitive function in Chinese middle-aged and older adults, while considering the lagged effects of pollution.

Methods: Panel data were constructed by integrating the air pollutants concentration (particulate matter diameter ≤1 µm (μm) (PM), PM, PM, nitrogen dioxide (NO), and ozone (O)) among 28 provinces in China and the personal characteristics from China Health and Retirement Longitudinal Study participants during the period of 2011-2015.

Causal relationship between ankylosing spondylitis and ocular inflammatory diseases: a Mendelian randomization study.

Background: Observational studies have shown an increased risk of ocular inflammatory diseases in patients with ankylosing spondylitis (AS), but the genetically predicted association remains unclear. The aim of this study was to systematically assess the causal relationship between AS and ocular inflammatory diseases.

Methods: We conducted a two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between AS and several common ocular inflammatory diseases based on genome-wide association study (GWAS) data and public health data.

Simultaneous removal of nitrate, copper, carbamazepine, and calcium from micropolluted water by fulvic acid through promotion of denitrification and microbial-induced calcium precipitation: Performance and mechanism.

In this paper, a study of the denitrification strain Cupriavidus sp. W12 was conducted to remove copper (Cu), carbamazepine (CBZ), and calcium (Ca) by microbial-induced calcium precipitation (MICP) after adding fulvic acid (FA). After the addition of 20 mg/L FA, the removal efficiencies of nitrate (NO-N), Cu, CBZ, and Ca reached 100.

Preparation and Application of Polyclonal Antibodies for the Rapid Detection of Actinidia Chlorotic Ringspot-Associated Virus.

Actinidia chlorotic ringspot-associated virus (AcCRaV, ) is prevalent in Chinese kiwifruit, leading to substantial yield reduction. The intricate nature of symptoms presents diagnostic challenges, underscoring the necessity for a rapid and accurate detection method that facilitates effective control. In this investigation, AcCRaV isolates from key kiwi-producing regions in Sichuan province were collected and analyzed, with representative strains chosen as experimental materials.

GHRH-stimulated pituitary small extracellular vesicles inhibit hepatocyte proliferation and IGF-1 expression by its cargo miR-375-3p.

Small extracellular vesicles (sEV) have emerged as a novel mode of intercellular material transport and information transmission. It has been suggested hormones may regulate the production and function of sEV. However, the specific impact of growth hormone-releasing hormone (GHRH) on pituitary sEV production and the role of sEV in the regulation of the GHRH-GH-IGF axis has not been previously reported.

Factors influencing the turnover intention for disease control and prevention workers in Northeast China: an empirical analysis based on logistic-ISM model.

Purpose: This study aimed to determine the current turnover intention among workers at Centers for Disease Control and Prevention (CDCs) in Northeast China and to investigate the factors contributing to this phenomenon.

Materials And Methods: The cross-sectional study was conducted in May 2023 across four northeastern provinces of China. The study included a total of 11,912 valid participants who were CDC workers selected using a stratified cluster sampling method.

A Three-Dimensional Modeling Approach for Carbon Nanotubes Filled Polymers Utilizing the Modified Nearest Neighbor Algorithm.

Carbon nanotubes (CNTs) are extensively utilized in the fabrication of high-performance composites due to their exceptional mechanical, electrical, and thermal characteristics. To investigate the mechanical properties of CNTs filled polymers accurately and effectively, a 3D modeling approach that incorporates the microstructural attributes of CNTs was introduced. Initially, a representative volume element model was constructed utilizing the modified nearest neighbor algorithm.