Publications by authors named "Yuxuan Lin"

Preparing chiral polymers by using achiral building blocks in an achiral reaction environment is very demanding because this strategy avoids the use of expensive chiral reagents. Here, a surface-confined and sequence-controlled chiral copolymer is synthesized by the organometallic reactions between the achiral precursors 4,4″-dibromo-1,1':3',1''-terphenyl and 1-ethynyl-4-[2-(4-ethynylphenyl)ethynyl]benzene on an achiral Ag(111) surface. Combined scanning tunneling microscopy and density functional theory explorations show that the terminal alkyne and aromatic bromide precursors undergo dehydrogenated and debrominated metalations with surface Ag adatoms to yield the organometallic polymeric products.

View Article and Find Full Text PDF

To assess a subject with multiple factors or attributes, a comprehensive evaluation index, or say a composite indicator, is often constructed to make a holistic judgement. The key problem is to assign weights to the factors. There are various weighting methods in the literature, but a gold standard is lacking.

View Article and Find Full Text PDF

Background: The role of angiotensin system inhibitors (ASIs) in modifying the prognosis for patients undergoing pancreatic cancer resection is not yet definitively established. This meta-analysis endeavors to consolidate existing real-world data to provide a robust, evidence-based assessment of their impact on clinical outcomes.

Methods: A meticulous search strategy was devised and executed across PubMed, Embase, and Web of Science databases to retrieve all relevant studies evaluating the prognostic impact of ASIs in patients who have undergone resection for pancreatic cancer.

View Article and Find Full Text PDF

The bulk phase of transition metal nitrides (TMNs) has long been a subject of extensive investigation due to their utility as coating materials, electrocatalysts, and diffusion barriers, attributed to their high conductivity and refractory properties. Downscaling TMNs into two-dimensional (2D) forms would provide valuable members to the existing 2D materials repertoire, with potential enhancements across various applications. Moreover, calculations have anticipated the emergence of uncommon physical phenomena in TMNs at the 2D limit.

View Article and Find Full Text PDF

Purpose: The prognostic significance of concomitant statin use in cancer treatment with immune checkpoint inhibitors (ICIs) remains a subject of ongoing investigation. This study aims to clarify the prognostic value of statin use in this patient population and to provide a robust, evidence-based foundation to guide therapeutic decisions.

Methods: A systematic search strategy was used across a multitude of digital archives to exhaustively identify all relevant academic literature published up until June 20, 2024.

View Article and Find Full Text PDF

Background: Shared decision-making (SDM) is crucial in healthcare to facilitate effective communication between providers and patients, aiding in making optimal medical decisions. Communication skills training (CST) can improve physicians' ability in SDM. However, SDM CST for medical students in Taiwan is scarce, and research comparing online versus in-person CST outcomes is lacking.

View Article and Find Full Text PDF

: To evaluate the value of the postvascular phase of contrast-enhanced ultrasound (CEUS) in differentiating between benign and metastatic lymph nodes (LNs) in patients with breast cancer (BC). : This study retrospectively analyzed 96 suspicious LNs in the lymphatic drainage area of the breast from 90 patients with BC. All LNs were assessed by conventional ultrasound (US) and CEUS following intravenous Sonazoid injection.

View Article and Find Full Text PDF

Good lattice point (GLP) sets are a type of number-theoretic method widely utilized across various fields. Their space-filling property can be further improved, especially with large numbers of runs and factors. In this paper, Kullback-Leibler (KL) divergence is used to measure GLP sets.

View Article and Find Full Text PDF
Article Synopsis
  • * It explores properties of the GAST distribution, including moment calculations and the relationship between distribution peaks and parameters, alongside three methods (Monte Carlo, quasi-Monte Carlo, and mean square error) for generating representative points (RPs).
  • * The study finds that mean square error RPs are most effective for estimating moments and densities of the GAST distribution, and compares a revised maximum likelihood estimation method against traditional methods, proving its suitability for certain GAST distribution patterns with real data applications.
View Article and Find Full Text PDF
Article Synopsis
  • - The study investigates "pinhead," a condition affecting farmed fish like milkfish, characterized by extreme weight loss and lack of appetite, comparing it to healthy and starved fish.
  • - Results show that pinhead milkfish exhibit lower overall health metrics and signs of internal water imbalance, with high levels of the anorexigenic hormone leptin A, possibly contributing to their anorexia.
  • - This research highlights the physiological impacts of pinhead condition for the first time, indicating a need for further exploration of stress factors leading to this issue and potential solutions to improve fish health.
View Article and Find Full Text PDF
Article Synopsis
  • Concentrated Growth Factor (CGF) is a biomaterial that helps in tissue regeneration, and while it's well-studied in intraoral procedures, its effectiveness in maxillary sinus lifting is less documented.
  • A thorough literature review was conducted, which identified 13 out of 783 studies that looked at CGF's impact on maxillary sinus augmentation, emphasizing clinical, radiographic, and histological results.
  • Most studies indicated that CGF positively affected maxillary sinus augmentation by improving new bone formation and implant survival, though more rigorous clinical trials are needed to confirm these findings.
View Article and Find Full Text PDF

Background: Liver is one of the most preferred destinations for distant metastasis of gastric cancer (GC) and liver metastasis usually predicts poor prognosis. The achievement of liver metastasis requires continued cross-talk of complex members in tumor microenvironment (TME) including tumor associated macrophages (TAMs).

Methods: Results from 35 cases of ex vivo cultured living tissues of GC liver metastasis have elucidated that circadian rhythm disorder (CRD) of key molecules involved in circadian timing system (CTS) facilitates niche outgrowth.

View Article and Find Full Text PDF
Article Synopsis
  • * Researchers conducted single-cell RNA sequencing in mice to identify differences in gene expression between healthy and mutated pituitary cells, discovering a transitional cell state that may influence the development of endocrine cells.
  • * The study found that the gene being overexpressed in mutant mice does not impact normal pituitary development, suggesting that the loss of Prophet of Pit-1 is not a direct cause of CPHD, prompting further investigation into the role of other upregulated genes in affected cells.
View Article and Find Full Text PDF

Atomically precise graphene nanoribbons (GNRs) synthesized from the bottom-up exhibit promising electronic properties for high-performance field-effect transistors (FETs). The feasibility of fabricating FETs with GNRs (GNRFETs) has been demonstrated, with ongoing efforts aimed at further improving their performance. However, their long-term stability and reliability remain unexplored, which is as important as their performance for practical applications.

View Article and Find Full Text PDF
Article Synopsis
  • The study examines how previous pelvic radiotherapy impacts bone marrow suppression in 129 recurrent cervical cancer patients undergoing chemotherapy, comparing those with and without a history of radiotherapy.
  • Results showed that 94.8% of patients with prior radiotherapy experienced bone marrow suppression, while 75.0% of those without prior treatment did, indicating a significant difference (P < 0.05).
  • Severe bone marrow suppression (grades III-IV) was notably higher in patients with radiotherapy history (41.6%) compared to those without (13.5%), with specific radiotherapy methods identified as risk factors.
View Article and Find Full Text PDF

Extending the inventory of two-dimensional (2D) materials remains highly desirable, given their excellent properties and wide applications. Current studies on 2D materials mainly focus on the van der Waals (vdW) materials since the discovery of graphene, where properties of atomically thin layers have been found to be distinct from their bulk counterparts. Beyond vdW materials, there are abundant non-vdW materials that can also be thinned down to 2D forms, which are still in their early stage of exploration.

View Article and Find Full Text PDF
Article Synopsis
  • A study focused on the 70% ethanol extract of a fruit led to the discovery of three new triterpenoids, alongside twenty-seven already known compounds.
  • The structure of these compounds was determined using advanced techniques like NMR spectroscopy and mass spectrometry.
  • The research found that some triterpenoids exhibited significant neuroprotective effects against neurotoxicity in human neuroblastoma cells, suggesting their potential role in protecting nerve cells.
View Article and Find Full Text PDF

Aims: Cellular senescence (CS) represents an intracellular defense mechanism responding to stress signals and can be leveraged as a "vulnerability" in cancer treatment. This study aims to construct a CS atlas for gastric cancer (GC) and uncover potential therapeutics for GC patients.

Materials And Methods: 38 senescence-associated regulators with prognostic significance in GC were obtained from the CellAge database to construct Gastric cancer-specific Senescence Score (GSS).

View Article and Find Full Text PDF

Flexible and stretchable thin-film transistors (TFTs) are crucial in skin-like electronics for wearable and implantable applications. Such electronics are usually constrained in performance owing to a lack of high-mobility and stretchable semiconducting channels. Tellurium, a rising semiconductor with superior charge carrier mobilities, has been limited by its intrinsic brittleness and anisotropy.

View Article and Find Full Text PDF
Article Synopsis
  • The study compares the cost-effectiveness of two treatments for advanced liver cancer: tislelizumab and sorafenib in China.
  • A cost-effectiveness analysis using a partitioned survival model found that tislelizumab costs $16,181.24 with a gain of 0.18 quality-adjusted life years (QALYs), while sorafenib costs $14,306.87.
  • The incremental cost-effectiveness ratio (ICER) for tislelizumab is $10,413.17 per QALY, which is below the willingness-to-pay threshold, indicating it is a cost-effective option compared to sorafenib.
View Article and Find Full Text PDF

Electrons not only serve as a "reactant" in redox reactions but also play a role in "catalyzing" some chemical processes. Despite the significance and ubiquitousness of electron-induced chemistry, many related scientific issues still await further exploration, among which is the impact of molecular assembly. In this work, microscopic insights into the vital role of molecular assembly in tweaking the electron-induced surface chemistry are unfolded by combined scanning tunneling microscopy and density functional theory studies.

View Article and Find Full Text PDF

Background: Patients with malignancies have an increased risk of suffering ischemic stroke via several mechanisms such as coagulation dysfunction and other malignancy-related effects as well as iatrogenic causes. Moreover, stroke can be the first sign of an occult malignancy, termed as malignancy-associated ischemic stroke (MAS). Therefore, timely diagnostic assessment and targeted management of this complex clinical situation are critical.

View Article and Find Full Text PDF
Article Synopsis
  • * The compounds were isolated using various chromatography techniques, and their structures were analyzed with different spectroscopy methods.
  • * Five of the isolated compounds showed significant cytotoxic effects against human glioma cells (LN229), suggesting potential anti-cancer properties.
View Article and Find Full Text PDF

Background: Cervical cancer survivors can experience vaginal length shortening, vaginal stenosis, vaginal elasticity deterioration, sexual frequency reduction and sexual dysfunction. This prospective, uncontrolled, monocentric clinical interventional study aimed to evaluate the effect of vaginal dilation therapy on vaginal condition and sexual function of cervical cancer survivors who had not received timely vaginal dilation.

Methods: A total of 139 patients completed the study.

View Article and Find Full Text PDF

Objective: The aim of this study was to develop and prospectively validate a prediction model for superficial lymphadenopathy differentiation using Sonazoid contrast-enhanced ultrasound (CEUS) combined with ultrasound (US) and clinical data.

Methods: The training cohort comprised 260 retrospectively enrolled patients with 260 pathological lymph nodes imaged between January and December 2020. Two clinical US-CEUS models were created using multivariable logistic regression analysis and compared using receiver operating characteristic curve analysis: Model 1 included clinical and US characteristics; Model 2 included all confirmed predictors, including CEUS characteristics.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionj4to82iesuurbqqn0p34m0k2v7nqjnoi): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once