Hypoxia-inducible factors (HIFs) in early pregnancy: implications for miscarriage†.

Miscarriage poses a significant threat to both maternal and fetal health. Its etiology remains unknown, and there are no established effective identification or prevention strategies. A low-oxygen environment in early pregnancy is a physiological necessity for embryonic and placental growth.

A lithium ore grade measurement based on the neutron & X-ray bi-modal imaging system.

The grades of the minerals significantly affects the energy consumption and chemical pollution along with the beneficiation process for extracting lithium element from the ores. Based on the large neutrons' macro cross section of the LiO cluster inside the ores, the grades of lithium ores could be analyzed by the thermal neutron penetrating information. In this work, a bimodal imaging method, which utilizes both the information of penetrating neutrons and X-rays delivered by the same electron linear accelerator driven photoneutron system, was proposed to investigate the lithium concentration of each ore.

Robust Thermal Neutron Detection by LiInP Se Bulk Single Crystals.

Direct neutron detection based on semiconductor crystals holds promise to transform current neutron detector technologies and further boosts their widespread applications. It is, however, long impeded by the dearth of suitable materials in the form of sizeable bulk crystals. Here, high-quality centimeter-sized LiInP Se single crystals are developed using the Bridgman method and their structure and property characteristics are systematically investigated.

A Design for the High Yield Photoneutron Source Target Station.

Low energy accelerator driven neutron sources are promising candidates to obtain a neutron yield as high as 10 n/s, which is required for a variety of applications, such as boron neutron capture therapy, neutron imaging, and neutron scattering. The methods to generate neutrons can be divided into two categories: hadron-based and photon-based methods. In order to better understand which kind of source would be the better choice for delivering a brilliant neutron beam robustly, in this paper, the underlying principles of neutron production, as well as the simulation results of neutron yield, target heat dissipation, thermal stress, and reaction byproducts concentration of these two types of neutron sources, will be elaborated on.

Molecular Imprinting Polymers Electrochemical Sensor Based on AuNPs/PTh Modified GCE for Highly Sensitive Detection of Carcinomaembryonic Antigen.

A novel molecular imprinted polymer (MIP) electrochemical sensor was successfully fabricated for sensitive detection of carcinomaembryonic antigen (CEA). We used CEA as template, dopamine (DA) as imprinted monomers. Through controlling electropolymerization, a "PDA-CEA"complex was achieved.

Immunosensors Based on Nanomaterials for Detection of Tumor Markers.

Nanomaterials have been widely used to immobilize biomolecules, amplify the signals and concentrate the analytes for detection with good properties including large surface area, good adsorption capacity and high surface activity. In recent years, nanomaterials such as carbon nanomaterials, noble metal nanomaterials, polymers, are widely applied to research and develop immunosensors with high sensitivity and selectivity, which monitor the antigen-antibody reaction for the detection of tumor markers. This review provides an introduction of immunosensors and focuses on the design of electrochemical (EC) immunosensors, electrochemical luminscence (ECL) immunosensors and photoelectrochemical (PEC) immunosensors based on nanomaterials in nearly three years.