Heterologous expression of a nonconventional terpene biosynthetic gene cluster from the deepsea-derived Streptomyces amphotericinicus DS22-01 led to the production of a novel cyclic diterpene, ostamycin A (1). Anti-influenza A virus activity evaluation revealed that compound 1 showed significant activity with an IC value of 4.72 μM, which was much stronger than that of the positive control ribavirin (IC = 20.
View Article and Find Full Text PDFRedox imbalance induced by the accumulation of reactive oxygen species (ROS) accelerates age-related processes, often accompanied by a decrease in circadian rhythm amplitude. However, the underlying mechanisms by which ROS modulate circadian rhythms remain poorly understood. In this study, we found that ROS disrupt circadian rhythms in both zebrafish, as indicated by changes in diurnal behavior and clock gene expression, and in a human cell model.
View Article and Find Full Text PDFAlcoholic fatty liver disease (AFLD) is characterized by the accumulation of hepatic lipid and has no effective treatment yet. Fructus Corni is a traditional Chinese medicinal herb, and its extractions have demonstrated hepatoprotective properties. We hypothesize that the polysaccharides in Fructus Corni might have therapeutic effects on AFLD.
View Article and Find Full Text PDFUnlabelled: African swine fever (ASF) is a highly contagious and often lethal disease caused by African swine fever virus (ASFV) in pigs. Protein palmitoylation is a prevalent posttranslational lipid modification that can modulate viral replication. In this study, we investigated the palmitoylation of ASFV proteins.
View Article and Find Full Text PDFSuperoxide dismutases (SODs) are key enzymes for scavenging insects' excess reactive oxygen species (ROS) and play a crucial role in resisting a variety of stresses. The deletion of SOD genes can alter the response of insects to abiotic stresses. In this study, four genes of the superoxide dismutase family in Tetranychus urticae were identified and analyzed, among which three copper/zinc SODs and a manganese SOD.
View Article and Find Full Text PDFAfrican swine fever (ASF), a highly infectious and devastating disease affecting both domestic pigs and wild boars, owes its etiology to African swine fever virus (ASFV). ASFV encodes more than 165 proteins. However, novel immunogenic proteins remain unknown.
View Article and Find Full Text PDFAs environmental awareness increases, the use of recyclable plastics has risen. However, it is currently unclear whether recycled microplastics (MPs) pose a lesser or greater environmental risk than pristine MPs. Cadmium (Cd), known for its toxicity to most organisms, can bind with MPs and accumulate in sediments.
View Article and Find Full Text PDFAfrican swine fever virus (ASFV) is the causative agent of African swine fever (ASF), a highly contagious disease that can kill up to 100% of domestic pigs and wild boars. It has been shown that the pigs inoculated with some ASF vaccine candidates display more severe clinical signs and die earlier than do pigs not immunized. We hypothesize that antibody-dependent enhancement (ADE) of ASFV infection may be caused by the presence of some unidentified antibodies.
View Article and Find Full Text PDFIntroduction: In dental clinical practice, cone-beam computed tomography (CBCT) is commonly used to assist practitioners to recognize the complex morphology of root canal systems; however, because of its resolution limitations, certain small anatomical structures still cannot be accurately recognized on CBCT. The purpose of this study was to perform image super-resolution (SR) processing on CBCT images of extracted human teeth with the help of a deep learning model, and to compare the differences among CBCT, super-resolution computed tomography (SRCT), and micro-computed tomography (Micro-CT) images through three-dimensional reconstruction.
Methods: The deep learning model (Basicvsr++) was selected and modified.
Aim: To understand how liver sinusoidal endothelial cells (LSECs) respond to nonalcoholic steatohepatitis (NASH).
Methods: We profiled single-LSEC from livers of control and MCD-fed mice. The functions of C-Kit-LSECs were determined using coculture and bone marrow transplantation (BMT) methods.
Melittin, a classical antimicrobial peptide, is a highly potent antitumor agent. However, its significant toxicity seriously hampers its application in tumor therapy. In this study, we developed novel melittin analogs with pH-responsive, cell-penetrating and membrane-lytic activities by replacing arginine and lysine with histidine.
View Article and Find Full Text PDFIn this article, we report a Si/Ge waveguide phototransistor with high responsivity and low dark current under low bias voltages, due to an engineered electric field distribution. The photodetector consists of n-i-p-i-n doping regions and shows a responsivity of 606 A/W at 1 V bias, and 1032 A/W at 2.8V bias with an input optical power of -50 dBm, and dark current of 4 µA and 42 µA respectively.
View Article and Find Full Text PDFBull Environ Contam Toxicol
December 2023
Recent studies have shown that the microplastics in waste activated sludge (WAS) can directly reduce the microbial activity and influence the performance of anaerobic digestion. Unfortunately, few studies paid attention on the interactions between WAS and MPs, since MPs could impact the contact between sludge flocs and microorganisms. We found that PVC-MP changed the interfacial energy properties of the WAS surface and affected methane production.
View Article and Find Full Text PDFThe present study aimed to investigate potential functional network brain-activity abnormalities in individuals with orbital fracture (OF) using the voxel-wise degree centrality (DC) technique. The present study included 20 patients with OF (12 males and 8 females) and 20 healthy controls (HC; 12 males and 8 females), who were matched for gender, age and educational attainment. Functional magnetic resonance imaging (fMRI) in the resting state has been widely applied in several fields.
View Article and Find Full Text PDFLight intensity is a determinant for submerged macrophytes. Little is known about their molecular responses to low-light exposure, despite more informative and responsive than morphological traits. For erect-type submerged macrophytes, the stem is more crucial relative to the leaf in acclimation to low-light stress, but receives less attention.
View Article and Find Full Text PDFIEEE Trans Neural Netw Learn Syst
December 2024
In this article, a dynamic event-triggered adaptive antidisturbance (ETAAD) switching control strategy is proposed for switched systems subject to multisource disturbances. The disturbances are divided into two categories: the available unmodeled disturbance and the unavailable dynamic neural network modeled disturbance. First, a dynamic ET criterion is set based on the system state.
View Article and Find Full Text PDFSaline-alkali soils constitute a globally important carbon pool that plays a critical role in soil carbon dioxide (CO) and methane (CH) fluxes. However, the relative importance of microorganisms in the regulation of CH emissions under elevated salinity remains unclear. Here, we report the composition of CH production and oxidation microbial communities under five different salinity levels in the Yellow River Delta, China.
View Article and Find Full Text PDFObjectives: Osteoarthritis (OA) is the most common joint disease. The occurrence and progression of OA are regulated by epigenetics. A large number of studies have shown the important regulatory role of noncoding RNAs in joint diseases.
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