Lactiplantibacillus plantarum SG5 inhibits neuroinflammation in MPTP-induced PD mice through GLP-1/PGC-1α pathway.

Mounting evidence suggests that alterations in gut microbial composition play an active role in the pathogenesis of Parkinson's disease (PD). Probiotics are believed to modulate gut microbiota, potentially influencing PD development through the microbiota-gut-brain axis. However, the potential beneficial effects of Lactiplantibacillus plantarum SG5 (formerly known as Lactobacillus plantarum, abbreviated as L.

A variable speed limit control approach for freeway tunnels based on the model-based reinforcement learning framework with safety perception.

To improve the traffic safety and efficiency of freeway tunnels, this study proposes a novel variable speed limit (VSL) control strategy based on the model-based reinforcement learning framework (MBRL) with safety perception. The MBRL framework is designed by developing a multi-lane cell transmission model for freeway tunnels as an environment model, which is built so that agents can interact with the environment model while interacting with the real environment to improve the sampling efficiency of reinforcement learning. Based on a real-time crash risk prediction model for freeway tunnels that uses random deep and cross networks, the safety perception function inside the MBRL framework is developed.

MSLTE: multiple self-supervised learning tasks for enhancing EEG emotion recognition.

. The instability of the EEG acquisition devices may lead to information loss in the channels or frequency bands of the collected EEG. This phenomenon may be ignored in available models, which leads to the overfitting and low generalization of the model.

Neuroprotective Effects of Bifidobacterium animalis subsp. lactis NJ241 in a Mouse Model of Parkinson's Disease: Implications for Gut Microbiota and PGC-1α.

Intestinal dysbiosis plays a critical role in the pathogenesis of Parkinson's disease (PD), and probiotics have emerged as potential modulators of central nervous system function through the microbiota-gut-brain axis. This study aimed to elucidate the anti-inflammatory effects and underlying mechanisms of the probiotic strain Bifidobacterium animalis subsp. lactis NJ241 (NJ241) in a mouse model of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

A chromatographic method for determining the interaction between a drug and two target proteins by fabricating a dual-heterogeneous surface.

Characterization of the drug-target interactions is pivotal throughout the whole procedure of drug development. Most of the current assays, particularly, chromatographic methods lack the capacity to reveal drug adsorption on the muti-target surface. To this end, we derived a reliable and workable mathematical equation for revealing drug bindings to dual targets on the heterogeneous surface starting from the mass balance equation.

Light-Induced TaHY5-7A and TaBBX-3B Physically Interact to Promote Expression in Purple-Grained Wheat.

Purple-grained wheat ( L.) is an important germplasm source in crop breeding. Anthocyanin biosynthesis in the pericarps of purple-grained wheat is largely light-dependent; however, the regulatory mechanisms underlying light-induced anthocyanin accumulation in the wheat pericarp remain unknown.

SFXN3 is Associated with Poor Clinical Outcomes and Sensitivity to the Hypomethylating Therapy in Non-M3 Acute Myeloid Leukemia Patients.

Background: DNA hypermethylation plays a critical role in the occurrence and progression of acute myeloid leukemia (AML). The mitochondrial serine transporter, SFXN3, is vital for onecarbon metabolism and DNA methylation. However, the impact of SFXN3 on the occurrence and progression of AML has not been reported yet.

Metallo-β-lactamase SMB-1 evolves into a more efficient hydrolase under the selective pressure of meropenem.

Metallo-β-lactamases (MβLs) are the primary mechanism of resistance to carbapenem antibiotics. To elucidate how MβLs have evolved with the introduction and use of antibiotics, the mutation and evolution of SMB-1 from Serratia marcescens were investigated in microbial evolution plates containing discontinuous meropenem (MEM) concentration gradients. The results revealed 2-point mutations, A242G and S257R; 1 double-site mutation, C240G/E258G; and 3 frameshift mutations, M5, M12, and M13, which are all missense mutations situated at the C-terminus.

Genome-wide analysis of Hsp40 and Hsp70 gene family in four cotton species provides insights into their involvement in response to and abiotic stress.

Cotton is an important economic crop to provide natural fibers as raw materials to textile industry, and is significantly affected by biotic and abiotic stress during the whole growth stage, in which wilt (VW) caused by is one of the most destructive disease to lead to a significant yield reduction. Heat shock proteins (Hsps) are important molecular chaperones, and play crucial roles in plant growth, development, resistance to biotic and abiotic stress. Hsp40 and Hsp70 are two key Hsps in cell chaperone network, however, the function and regulatory mechanism of Hsp40 and Hsp70 members in VW resistance and abiotic stress in cotton are largely unknown.

An Efficient Hybrid Linear Clustering Superpixel Decomposition Framework for Traffic Scene Semantic Segmentation.

Superpixel decomposition could reconstruct an image through meaningful fragments to extract regional features, thus boosting the performance of advanced computer vision tasks. To further optimize the computational efficiency as well as segmentation quality, a novel framework is proposed to generate superpixels from the perspective of hybridizing two existing linear clustering frameworks. Instead of conventional grid sampling seeds for region clustering, a fast convergence strategy is first introduced to center the final superpixel clusters, which is based on an accelerated convergence strategy.

Treatment of COVID-19 by monoclonal antibodies and the traditional Chinese medicine.

The mortality rate of the recent global pandemic corona virus disease 2019 (COVID-19) is currently as high as 7%. The SARS-CoV-2 virus is the culprit behind COVID-19. SARS-CoV-2 is an enveloped single-stranded RNA virus, the genome encodes four types of the structural proteins: S protein, E protein (envelope protein), M protein (matrix protein) and N protein (nucleocapsid protein).

Molecular Design, Supramolecular Assembly, and Excellent Dye Adsorption Capacity of Natural Rigid Dehydroabietic Acid-Tailored Amide Organogelators.

It is very appealing to synthesize functional soft materials from natural and abundant plant diterpenes because they have conformationally rigid and chiral properties. Herein, dehydroabietic-based monoamide (DA-1) and diamide (DA-2) were designed by introducing device interactions, π-π stacking and hydrogen bonding, with an aromatic group, C═O, and N-H. DA-1 and DA-2 can be gelled in a mixed solvent and a single solvent, respectively.

Liraglutide Regulates Mitochondrial Quality Control System Through PGC-1α in a Mouse Model of Parkinson's Disease.

Parkinson's disease (PD) is a multifactorial disorder, and there is strong evidence that mitochondria play an essential role in the disorder. Factors that regulate the mechanism of the mitochondrial quality control system have been drawing more and more attention. PGC-1α (peroxisome proliferator-activated receptor-γ coactivator-1α) is a powerful transcription factor involved in regulation of mitochondrial function.

Neuroprotective effects of liraglutide against inflammation through the AMPK/NF-κB pathway in a mouse model of Parkinson's disease.

Parkinson's disease (PD) is a neurodegenerative disease with increasing incidence in aged populations, second only to Alzheimer's disease. Increasing evidence has shown that inflammation plays an important role in the occurrence and development of Parkinson's disease. Growing evidence has shown that AMP-activated protein kinase (AMPK) and NF-κB are closely related to inflammation.

Boosting transparent electromagnetic interference shielding by multi-cavity resonances.

We propose a multi-cavity resonant architecture that is established by employing two opposing ultrathin silver-based films to form a Fabry-Pérot (F-P) cavity and inserting one or two metallic mesh layers in between. Compared with the single F-P cavity, the multi-cavity architecture with one metallic mesh layer experimentally exhibits a ∼37 improvement in the average shielding effectiveness and maintains a transmittance over 80% at 550 nm. A more significant improvement of ∼108 in shielding effectiveness (SE) can be achieved by inserting two metallic mesh layers.

Record-High Transparent Electromagnetic Interference Shielding Achieved by Simultaneous Microwave Fabry-Pérot Interference and Optical Antireflection.

As a potential risk to human and environmental health, radio frequency (RF) radiation should be studied due to the higher frequencies and larger bandwidths that may be employed. Electromagnetic interference (EMI) shielding materials can prevent exposure to RF radiation, but most of them are visibly opaque. In this work, we propose and fabricate visibly transparent EMI shielding materials using an ultrathin silver layer sandwiched by oxides (SLSO) as building blocks.

Draft Genome Sequence of a Selenite- and Tellurite-Reducing Marine Bacterium, Lysinibacillus sp. Strain ZYM-1.

Lysinibacillus sp. ZYM-1, a Gram-positive strain isolated from marine sediments, reduces selenite and tellurite efficiently. Meanwhile, it also exhibits high resistance to Zn2+ and Mn2+.