Aquaculture source of atmospheric NO in China: Comparison of system types, management practices and measurement methods.

Aquaculture systems contribute to atmospheric NO, but the magnitude of this NO source is largely uncertain. Here, we synthesized data from 139 aquaculture sites based on 59 peer-reviewed publications, and estimated that China's aquaculture systems emitted 9.68 Gg N yr (4.

Trait divergence and opposite above- and below-ground strategies facilitate moso bamboo invasion into subtropical evergreen broadleaf forest.

Understanding the invasion of moso bamboo () into adjacent evergreen broadleaf forest based on functional traits is crucial due to its significant influence on ecosystem processes. However, existing research has primarily focused on above- or below-ground traits in isolation, lacking a comprehensive integration of both. In this study, we conducted a trait-based analysis including 23 leaf traits and 11 root traits in three forest types - bamboo forest, mixed bamboo and broadleaf forest, and evergreen broadleaf forest - to investigate trait differences, phenotypic integration, and above- and below-ground resource strategies in bamboo and broadleaf species.

Rainstorm and strong wind weathers largely increase greenhouse gases flux in shallow ponds.

Shallow-water ponds represent the hotspots of greenhouse gas (GHG) emissions. Most current studies focus on the temporal dynamics for GHGs in water, with little consideration given to the effects of weather changes. In this study, we measured and compared the concentrations and fluxes of CO, CH, and NO from a pond in Northeast China under different meteorological conditions.

A designed cyclic peptide based on Trastuzumab used to construct peptide-drug conjugates for its HER2-targeting ability.

Human epidermal growth factor receptor 2 (HER2) has been recognized as an important therapeutic target for its overexpression in many cancers. Trastuzumab is a monoclonal antibody targeting HER2, which has been approved by FDA to treat HER2-positive cancer. In this research, cyclic peptide Cyclo-GCGPep1 was designed based on the binding mode between antibody and HER2 protein in silico, which has been confirmed possessing good affinity with HER2.

[Stoichiometry of carbon, nitrogen and phosphorus and their allometric relationship between leaves and fine roots of three functional tree seedlings.].

We analyzed the contents and stoichiometric ratios of carbon (C), nitrogen (N) and phosphorus (P) in leaves and fine roots of (an evergreen broad-leaved species), (a deciduous broad-leaved species) and (an evergreen coniferous species) to compare the leaf and root stoichiometry and allometric relationship between different functional groups of trees. There were significant difference in the contents and stoichiometry of C, N and P in the leaves and fine roots among different functional groups. C content, C/N and C/P of the leaves and roots were the highest in .

Discovery of a novel GLP-1/GIP dual receptor agonist CY-5 as long-acting hypoglycemic, anti-obesity agent.

Glucagon-like peptide-1 (GLP-1) receptor agonists as an effective approach for type 2 diabetes mellitus (T2DM) has been explored extensively, multi agonists based on GLP-1 may have better clinical benefits on obesity, Nonalcoholic steatohepatitis (NASH) and other metabolic diseases. To get multi agonists based on GLP-1, 15 conjugates were designed, synthesized, and tested for biological activity. GLP-1/glucagon dual receptor agonist E1 showed moderate long-acting hypoglycemic effect, CY-5 and CY-16 with GLP-1/GIP dual receptor agonistic activity exhibited longer duration of continuous blood glucose stabilization.

GLP-1R agonists for the treatment of obesity: a patent review (2015-present).

Introduction: Glucagon-like peptide-1 (GLP-1) is an endogenous peptide which is secreted by enteroendocrine L cells, GLP-1 receptor agonists (GLP-1 RAs) can exhibit glucoregulation by stimulating insulin release, promote satiety, delay gastric emptying, and reduce energy intake. Liraglutide is the only GLP-1 RA approved for the treatment of obesity. The phase III clinical study of semaglutide has completed and the result showed significant weight loss effect.

Design, synthesis and biological evaluation of novel 6-phenyl-1,3a,4,10b-tetrahydro-2H-benzo[c]thiazolo[4,5-e]azepin-2-one derivatives as potential BRD4 inhibitors.

Bromodomain-containing protein 4 (BRD4) is a key epigenetic regulator in cancer, and inhibitors targeting BRD4 exhibit great anticancer activity. By replacing the methyltriazole ring of the BRD4 inhibitor I-BET-762 with an N-methylthiazolidone heterocyclic ring, fifteen novel BRD4 inhibitors were designed and synthesized. Compound 13f had a hydrophobic acetylcyclopentanyl side chain, showing the most potent BRD4 inhibitory activity in the BRD4-BD1 inhibition assay (IC value of 110 nM), it also significantly suppressed the proliferation of MV-4-11 cells with high BRD4 level (IC value of 0.

Discovery of novel potent GPR40 agonists containing imidazo[1,2-a]pyridine core as antidiabetic agents.

Free fatty acid receptor 1 (FFA1 or GPR40) has been studied for many years as a target for the treatment of type 2 diabetes mellitus. In order to increase potency and reduce hepatotoxicity, a series of novel compounds containing imidazo[1,2-a]pyridine scaffold as GPR40 agonist were synthesized. Compound I-14 was identified as an effective agonist as shown by the conspicuous drop in blood glucose in normal and diabetic mice.