Discovered cassane diterpenoids from Caesalpinia mimosoides lam. Exhibited anti-renal fibrosis activity via regulating TGF-β1/Smads signaling pathway.

Renal fibrosis is marker and common pathway of progressive chronic kidney disease (CKD), eventually leading to renal dysfunction. So far, there is still a lack of secure drugs and effective therapeutic strategies. Caesalpinia mimosoides is an edible Dai folk medicinal plant and exhibits good effect on inducing diuresis to alleviate edema, hinting that C.

Proteomic analysis reveals immune-related proteins of coelomic fluid in Urechis unicinctus.

Urechis unicinctus is a marine benthic invertebrate that relies primarily on humoral immunity within the nonspecific immune system for body defense. In order to elucidate the protein components of the coelomic fluid and investigate its immune response mechanism, proteomic analysis and antimicrobial characterization of the coelomic fluid of U. unicinctus were carried out.

A large-scale open image dataset for deep learning-enabled intelligent sorting and analyzing of raw coal.

Under the strategic objectives of carbon peaking and carbon neutrality, energy transition driven by new quality productive forces has emerged as a central theme in China's energy development. Among these, the intelligent sorting and analysis of raw coal using deep learning constitute a pivotal technical process. However, the progress of intelligent coal preparation in China has been constrained by the absence of accurate and large-scale data.

A tortoise-inspired quadrupedal pneumatic soft robot that adapts to environments through shape change.

Multi-terrain adaptation and landing capabilities pose substantial challenges for pneumatic bionic robots, particularly in crossing obstacles. This paper designs a turtle-inspired quadrupedal pneumatic soft crawling robot with four deformable bionic legs to mimic the structure and movement of turtle legs. Finite element software is used to design and optimize the wall thickness of the soft actuator.

Metabolomics combined with network pharmacology reveals the effects of ripening stages and edible parts on bioactive ingredients of Luohan Guo (Siraitia grosvenorii).

Luohan Guo (Siraitia grosvenorii) is a traditional food homologous fruit in China, which is famous owing to its rich natural antioxidant secondary metabolites. However, the impacts of ripening stages and edible parts on high-resolution metabolic profiles of Luohan Guo are poorly understood till now, greatly limiting its comprehensive utilization. In this study, an LC-QTOF/MS-based non-targeted metabolomics approach was carried out to reveal the dynamic accumulation of metabolites in the peel and pulp of Luohan Guo across seven growth stages, and further revelation their potential pharmacological activities and mechanisms in the treatment of oxidative stress using the network pharmacology strategy.

Revealing the key antioxidant compounds and potential action mechanisms of Bauhinina championii honey based on non-targeted metabolomics, mineralogical analysis and physicochemical characterization.

Bauhinia championii (BC) honey, highly regarded for its functional properties, is popular among consumers and holds significant economic potential, particularly in the food and health industries. However, limited knowledge of the bioactivities, especially its outstanding antioxidant activity, hampers the development of functional products. This study comprehensively compared BC honey's physicochemical properties, elemental composition, metabolic profile, and antioxidant properties with five other honeys.

invasion significantly alters the assembly and structure of soil bacterial communities in the Yellow River Delta.

Soil microbial communities are integral to almost all terrestrial biogeochemical cycles, which are essential to coastal wetland functioning. However, how soil bacterial community assembly, composition, and structure respond to native and non-native plant invasions in coastal wetlands remains unclear. In this study of the coastal wetlands of the Yellow River Delta in China, the assembly, community composition, and diversity of soil bacterial communities associated with four wetland plant species (, , , and ) and four soil depths (0-10 cm, 10-20 cm, 20-30 cm, and 30-40 cm) were characterized using high-throughput sequencing.

Infection Alters the Microbiota of the Invasive Leaf-Miner (Diptera: Agromyzidae).

Microbe-microbe interactions within a host drive shifts in the host's microbiota composition, profoundly influencing host physiology, ecology, and evolution. Among these microbes, the maternally inherited endosymbiont is widespread in the invasive pest (Diptera: Agromyzidae). However, its influence on the host microbiota remains largely unexplored.

NK cell immunopotentiators-loaded nanoliposomes enhance ADCC effect for targeted therapy against HER2-positive breast cancer.

Trastuzumab serves as a cornerstone of first-line therapy for HER2-positive (HER2) breast cancer; however, a significant challenge arises due to the emergence of resistance within approximately one year of commencement of treatment, particularly in advanced cases with metastatic disease where its efficacy is limited. Our investigation into the tumor tissue from HER2 breast cancer patients, employing single-cell sequencing and bioinformatics analysis, has elucidated a crucial mechanism underlying the reduced responsiveness of tumors to trastuzumab: the diminished infiltration and activity of natural killer (NK) cells within the tumor microenvironment (TME). To counteract this impediment, we meticulously selected two potent immune-modulating peptides TKD and IP-10p, which are known to recruit and enhance the activity of NK cells.

Biochar-amended constructed wetlands enhance sulfadiazine removal and reduce resistance genes accumulation in treatment of mariculture wastewater.

With the rapid development of mariculture, an increasing amount of antibiotics are being discharged into the marine environment. Effectively removing antibiotics and antibiotic resistance genes (ARGs) in mariculture wastewater with a relatively high salinity and low C/N presents challenges. Biochar-amended constructed wetlands (CWs) can effectively remove antibiotics, However, few studies have compared the impacts of biochar-amended CWs pyrolyzed at different temperatures on the treatment of mariculture wastewater.

Targeting GDF15 to enhance immunotherapy efficacy in glioblastoma through tumor microenvironment-responsive CRISPR-Cas9 nanoparticles.

Despite the outstanding clinical success of immunotherapy, its therapeutic efficacy in glioblastoma (GBM) is still limited. To identify critical regulators of GBM immunity, we constructed a mouse single-guide RNA (sgRNA) library corresponding to all disease-related immune genes, and performed an in vivo CRISPR knockout (KO) screen in syngeneic GBM mouse models. We demonstrated that the deletion of GDF15 in GBM cells ameliorated the immunosuppressive tumor microenvironment (TME) and enhanced the antitumor efficacy of immune checkpoint blockade (ICB) response.

Multimodal radiopathological integration for prognosis and prediction of adjuvant chemotherapy benefit in resectable lung adenocarcinoma: A multicentre study.

Lung adenocarcinoma (LUAD) has a heterogeneous prognosis and controversial postoperative treatment protocols. We aim to develop and validate a multimodal analysis framework that integrates CT images with H&E-stained whole-slide images (WSIs) to enhance risk stratification and predict adjuvant chemotherapy benefit in LUAD patients. We retrospectively collected data from 1039 resectable LUAD patients (stage I-III) across four centres, forming a training dataset (n = 303), two testing datasets (n = 197 and n = 228) for survival analysis, and a feature testing dataset (n = 311) for interpretability analysis.

Synergistic strategies for glioblastoma treatment: CRISPR-based multigene editing combined with immune checkpoint blockade.

Glioblastoma (GBM) is a primary brain tumor known for its high levels of aggressiveness and resistance to current treatments such as radiotherapy and chemotherapy. As a result, there is a pressing need for innovative therapeutic approaches to combat GBM. Thus, we have developed an engineered multifunctional extracellular vesicle (EV) delivery system that offers an "all-in-one" strategy for GBM therapy.

Cyanamide-Based Cyclization Reactions for Nitrogen-Containing Heterocycles Synthesis.

Nitrogen-containing heterocycles, such as indoles and quinolines, serve as the key scaffolds in numerous pharmaceuticals, pesticides, and natural products. The synthesis methods of nitrogen-containing heterocycles show significant scientific and industrial value. As a chemical intermediate featuring dual functional groups, cyanamide plays a crucial role in organic synthesis, directly affecting the development of new drugs and the design of new materials.

Construction of a neutrophil extracellular trap formation-related gene model for predicting the survival of lung adenocarcinoma patients and their response to immunotherapy.

Background: Lung adenocarcinoma (LUAD) is associated with high morbidity and mortality rates. Increasing evidence indicates that neutrophil extracellular traps (NETs) play a critical role in tumor progression, metastasis and immunosuppression in the LUAD tumor microenvironment (TME). Nevertheless, the use of NET formation-related genes (NFRGs) to predict LUAD patient survival and response to immunotherapy has not been explored.

Template-assembly activation of primer exchange reaction for on-site and sensitive detection of copper ions in blood.

The sensitive and accurate detection of copper ions is crucial for public health, medical research, and environmental monitoring. In this study, we developed a sensor based on template-assembly activation of the primer exchange reaction (PER) for the on-site detection of copper ions in blood. Copper ions triggered the assembly of two template fragments into a hairpin structure via a click-chemistry reaction, activating the PER.

Photoexcited CuO/TiO Heterojunction for Photoelectrochemical Sensors for Nonenzymatic Glucose Detection.

Photoelectrochemical sensors have been studied for glucose detection because of their ability to minimize background noise and unwanted reactions. Titanium dioxide (TiO), a highly efficient material in converting light into electricity, cannot utilize visible light. In this regard, we developed a nonenzymatic glucose sensor by using a simple one-step electrospinning technique to combine cupric oxide with TiO to create a heterojunction.

Study on the foam production characteristics of air self-suction foam generator by jet.

Confined space fires could easily cause serious casualties and property damage, and foam is an effective means of preventing confined space fires. The existing foam generator does not have both momentum and foam expansion rate (FER) and is poorly suited to confined spaces. In order to develop a foam generator suitable for confined space fire protection, an in-depth analysis of the physical foaming characteristics of self-suction foam is required, and the structure of the foam generator is optimized accordingly.

Genetic syndromes associated with pancreatic neuroendocrine neoplasms and imaging diagnostic strategies.

Pancreatic neuroendocrine neoplasms (pNENs) are the second most common pancreatic malignancy. While most cases are sporadic, a small proportion is associated with genetic syndromes, such as Multiple Endocrine Neoplasia (MEN), Von Hippel-Lindau Syndrome (VHL), Neurofibromatosis Type 1 (NF1), and Tuberous Sclerosis Complex (TSC). This review aims to use pNENs as a clue to reveal the full spectrum of disease, providing a comprehensive understanding of diagnosis.

BEEx Is an Open-Source Tool That Evaluates Batch Effects in Medical Images to Enable Multicenter Studies.

The batch effect is a nonbiological variation that arises from technical differences across different batches of data during the data generation process for acquisition-related reasons, such as collection of images at different sites or using different scanners. This phenomenon can affect the robustness and generalizability of computational pathology- or radiology-based cancer diagnostic models, especially in multicenter studies. To address this issue, we developed an open-source platform, Batch Effect Explorer (BEEx), that is designed to qualitatively and quantitatively determine whether batch effects exist among medical image datasets from different sites.

The complete genomic sequence of Magnaporthe oryzae polymycovirus 1.

A novel double-stranded RNA virus, designated as "Magnaporthe oryzae polymycovirus 1" (MoPmV1), was identified in Magnaporthe oryzae strain TM02. MoPmV1 has four dsRNA fragments, ranging from 1324 to 2401 bp in length. DsRNA1, 2, and 3 of MoPmV1 each possess a single large open reading frame (ORF), whereas dsRNA4 contains two ORFs.