Review of Biomass-Derived Carbon Nanomaterials-From 0D to 3D-For Supercapacitor Applications.

The transition to sustainable energy storage solutions has driven significant interest in supercapacitors, which offer high power density, rapid charge-discharge capabilities, and exceptional cycle stability. Biomass-derived carbon nanomaterials have emerged as compelling candidates for supercapacitor electrodes due to their renewable origins, environmental compatibility, and cost-effectiveness. This study explores recent advancements in tailoring structural properties, for example in preparation methods and activation, which are essential for efficient charge storage and rapid ion transport.

A three-site recognition cytosensor for accurate detection of circulating tumor cells based on novel branched Pt Au nanospheres and MnO-GO-Au nanosheets.

A novel electrochemical cytosensor was developed with a three-protein recognition strategy, employing branched Pt Au nanospheres (B-Pt-Au NPs) as tags and MnO-GO-Au nanosheet-modified electrodes for circulating tumor cells (CTC) detection. This system integrates specific magnetic separation and CTC enrichment with sensitive electrochemical detection to identify rare A549 cells in whole blood. MnO-GO-Au nanosheets, known for their high conductivity and biocompatibility, were used to modify a bare electrode, improving the electrochemical interface for biomolecules.

N-acetylcysteine remodels the tumor microenvironment of primary and recurrent mouse glioblastoma.

Purpose: Glioblastoma (GBM) exhibits a high ROS character, giving rise to an immunosuppressive microenvironment and tumor vascular abnormality. This study investigated the potential effect of N-acetylcysteine (NAC), an antioxidant, on primary and recurrent mouse brain tumors.

Methods: We measured reactive oxygen species (ROS)/ glutathione (GSH) levels in human GBM.

Simultaneous Determination and Pharmacokinetics of Three Steroidal Alkaloids in Rat Plasma by UHPLC-MS After Oral Administration of Three Different Preparations of Fritillaria ussuriensis Maxim Bulb.

Pharmacokinetic studies can provide a method for optimizing preparations. In this study, three most abundant compounds from Fritillaria ussuriensis bulb were isolated, and a selective, sensitive new analytical method was developed. This method aims for the simultaneous determination of peimisine-3-O-β-D-glucopyranoside (1), karelinine (2), and peimisine (3) in rat plasma after oral administration of F.

Depressive intensity, duration, and their associations with cognitive decline: a population-based study in Korea.

Existing epidemiological studies have ignored the effect of depressive duration on cognitive decline despite the presence of biological cues and understudied the depression-cognition association in Asian countries in the context of increasing cognitive burden worldwide. We aimed to comprehensively characterize the effects of depressive duration and intensity on cognitive decline at the population level. A total of 6406 individuals from the Korean Longitudinal Study of Aging (KLoSA) from 2010 to 2018 were included to generate four datasets with durations of 2, 4, 6, and 8 years.

Xanthones explore the mechanism of p53/p21 signaling pathway to prevent cardiac aging and epigenetic regulation of Nrf2 gene.

Gentianella acuta (GA) is a folk medicine used by Ewenki people in Inner Mongolia to treat heart disease. Transcriptional inhibition caused by the increase of DNMT1/3A/3B levels inhibited Nrf2, an anti-aging factor with antioxidant effect in aging myocardia, and the level of Nrf2 decreased with the increase of age. The main chemical component of GA, xanthones, can reverse this inhibition.

Association Between Multimorbidity and Depression in Older Adults: Evidence From Six Large Longitudinal Cohorts.

Background: Multimorbidity may increase the risk of depression in older adults, but the global average effect of multimorbidity on depression remains unknown. This research aimed to exclude the regional heterogeneity to quantify the exposure-response association between multimorbidity and depression in older adults worldwide.

Method: We collected 23,947 participants aged 65 years or above from six large prospective cohorts from developed and developing countries, including Mexico, South Korea, Europe, America, China, and England.

A layered Janus metastructure for multi-physical quantity detection based on the second harmonic wave.

In the field of nonlinear optics and physical quantity detection, the use of the second harmonic wave (SHW) generated in ferroelectric crystals is proposed to realize multi-physical quantity detection with the Janus property. In view of the single physical quantity detected by the current research and the single application scenario, this paper proposes a multi-functional and novel nonlinear Janus metastructure (NJMS), which exploits the SHW to achieve highly sensitive multi-physical quantity detection in the terahertz frequency range and shows Janus properties in both the forward and backward directions of the system. The NJMS is realized to detect refractive indices, thicknesses, and angles with different modes in the forward and backward directions.

Association between cognitive decline and depression in middle-aged and older adults: Findings from six large cohorts in different countries.

Background: The relationship between depression and cognition in middle-aged adults is a topic of interest. Whether poor cognitive function exacerbates depression remains controversial. We clarified the association between cognitive decline and depression based on six nationwide cohorts.

Second harmonic generation based on graphene hyperstructure for higher resolution and performance on top of achieving fundamental wave detection in theory.

In this paper, an innovative one-dimensional graphene hyperstructure (GHS) is proposed, allowing for the concurrent detection of multiple physical parameters in both the fundamental and second harmonic generation. The sensing characteristics of GHS pertaining to magnetic field strength (B), incident electromagnetic wave angle (θ), and graphene thickness (d) are systematically investigated. Moreover, through the incorporation of second harmonic generation alongside fundamental detection, higher resolution and performance are achieved.

In Situ Gelling Eye Drops of Tacrolimus with Improved Ocular Delivery and Therapeutic Efficacy.

In situ gelling eye drops of tacrolimus (FK506 Gel) were developed to address the formulation challenge of tacrolimus for anterior ocular inflammatory diseases. Both in silico and in vitro investigations were conducted to screen a suitable cyclodextrin species to increase the drug solubility. Guanosine was employed as the gelator and combined with inclusion complexes of tacrolimus in the presence of borate anions to obtain FK506 Gel, which gelated when came into contact with cations in tear fluid and led to the formation of a nanofibrous hydrogel.

Ring-Opening α,β-Difunctionalization of Cyclopropanols with Azides Enables 4-Keto-Functionalized 1,2,3-Triazole Synthesis.

Selective C-C bond cleavage and transformation of organic small molecules to create products of increased value are one of the central goals in organic chemistry. In this study, we have developed a novel TEMPO-mediated ring-opening α,β-difunctionalization of cyclopropyl alcohols with organic azides to prepare structurally important 4-keto-1,2,3-triazoles under metal- and additive-free conditions. This protocol not only provides a straightforward and efficient method for the synthesis of 4-keto-functionalized 1,2,3-triazoles in one pot but also accomplishes the goal of constructing α,β-double C-N bonds via the ring opening of cyclopropyl alcohols for the first time.

Pharmacokinetics of two triterpenoid saponins and three flavonoids in Astragalus membranaceus leaves by UHPLC-MS/MS.

Astragalus membranaceus (A. membranaceus) leaves can be used both as a medicine and food material. Their main chemical components are flavonoids and triterpenoid saponins.

Association between depressive duration and cognitive decline in middle-aged and older adults: Evidence from the Health and Retirement Study 2010-2018.

Background: Depression has been found to be associated with cognitive decline, but whether longer depressive durations lead to more severe cognitive declines has not been investigated. We aimed to estimate the association between depressive duration and cognitive decline in middle-aged and older Americans based on a large-scale representative population study.

Methods: We included 27,886 participants from the Health and Retirement Study (HRS) in 2010-2018.

Polypyrrole deposited on the core-shell structured nitrogen-doped porous carbon@Ag-MOF for signal amplification detection of chloride ions.

An electrochemical platform for signal amplification probing chloride ions (Cl) is constructed by the composite integrating core-shell structured nitrogen-doped porous carbon@Ag-based metal-organic frameworks (NC@Ag-MOF) with polypyrrole (PPy). It is based on the signal of solid-state AgCl derived from Ag-MOF, since both NC and PPy have good electrical conductivity and promote the electron transport capacity of solid-state AgCl. NC@Ag-MOF was firstly synthesized with NC as the scaffold and then, PPy was anchored on NC@Ag-MOF by chemical polymerization.

Gallic acid-selenium nanoparticles with dual anti-inflammatory and antioxidant functions for synergistic treatment of acute kidney injury.

The overexpression of inflammatory factors is closely related to the pathogenesis of acute kidney injury (AKI). Additionally, the overproduction of reactive oxygen species (ROS) further exacerbates the inflammatory response. In light of this, monotherapies focused solely on inflammation have proven to be suboptimal.

Bufotalin enhances apoptosis and TMZ chemosensitivity of glioblastoma cells by promoting mitochondrial dysfunction via AKT signaling pathway.

Glioblastoma multiforme (GBM) is the most prevalent and lethal primary intracranial neoplasm in the adult population, with treatments of limited efficacy. Recently, bufotalin has been shown to have anti-cancer activity in a variety of cancers. This investigation aims to investigate the effect of bufotalin on GBM and elucidate its potential underlying mechanism.