circAFF2 promotes the development of AML by binding to PML mRNA.

AML is a complex disease caused by multiple molecular mechanisms. As an important regulatory molecule, the role of circRNA in AML is not fully understood. By performing high-throughput sequencing on clinical samples, we systematically identified the differences in circRNA expression and distribution between AML and healthy donor samples.

The effect of different visual feedback interfaces of music training games on speech rehabilitation in hearing-impaired children: An fNIRS study.

Singing plays a critical role in enhancing musicality, sound discrimination, and attention, and proves advantageous for speech rehabilitation in children with hearing impairments. Computer-based training games are well-suited to the learning behaviors of children, with substantial evidence suggesting that music training augments speech training capabilities in this demographic. Despite this, there is a lack of detailed exploration into the design of interactive online music training interfaces tailored for these needs.

Effect of climate change on (Vaniot) C. Y. Wu & S. J. Hsuan distribution adopting temporal data, ArcGIS, and the MaxEnt model.

(Vaniot) C. Y. Wu & S.

A global view of altered ligand-receptor interactions in bone marrow aging based on single-cell sequencing.

Altered cell-cell communication is a hallmark of aging, but its impact on bone marrow aging remains poorly understood. Based on a common and effective pipeline and single-cell transcriptome sequencing, we detected 384,124 interactions including 2575 ligand-receptor pairs and 16 non-adherent bone marrow cell types in old and young mouse and identified a total of 5560 significantly different interactions, which were then verified by flow cytometry and quantitative real-time PCR. These differential ligand-receptor interactions exhibited enrichment for the senescence-associated secretory phenotypes.

Molecular and circuit mechanisms underlying avoidance of rapid cooling stimuli in C. elegans.

The mechanisms by which animals respond to rapid changes in temperature are largely unknown. Here, we found that polymodal ASH sensory neurons mediate rapid cooling-evoked avoidance behavior within the physiological temperature range in C. elegans.

Effect and mechanism of hydrogen-rich bath on mice with imiquimod-induced psoriasis.

The purpose of this study was to investigate whether hydrogen-rich bath has therapeutic effect on psoriasis and its molecular mechanism. Mice with imiquimod-induced psoriasis were established and divided into groups. The mice were respectively treated with hydrogen-rich water bath and distilled water bath.

A Monte Carlo simulation-based health risk assessment of heavy metals in soils of an oasis agricultural region in northwest China.

In recent years, heavy metal contamination of soils has been increasing, posing a major threat to food security, human health, and soil ecosystems. This study analyzed the spatial characteristics, contamination sources, risks of heavy metals by collecting topsoil samples from farmland in an oasis agricultural region in northwest China. The results found that soil heavy metals in farmland were at a moderate contamination level.

Pollution characteristics of soil heavy metals around two typical copper mining and beneficiation enterprises in Northwest China.

In order to investigate the situation of heavy metal pollution in the heavy metal industry in Gansu Province, a large copper mining province, two large and typical copper mining and beneficiation enterprises with differences in topographic features, climatic conditions, and soil types were selected as the target of this study based on similar ore types and beneficiation processes. Around these two enterprises, geochemical baselines of the six heavy metals were established, while the degree of local soil heavy metal pollution and potential hazards to humans were assessed based on statistical analysis, single-factor and multi-factor index analysis, and health risk evaluation models. In addition, Spearman's correlation analysis and hierarchical cluster analysis were used to explore the intrinsic association between each heavy metal in the two mining industries to reveal the pattern of soil heavy metal pollution in the copper mining and beneficiation industry and to propose targeted measures to improve and prevent soil heavy metal pollution.

Probabilistic risk assessment of heavy metals in urban farmland soils of a typical oasis city in northwest China.

Previous studies lacked quantitative evaluation studies of the probability of ecology and human health risks from soil heavy metals. This study assessed heavy metal risk level by collecting topsoil samples from a typical oasis city (Wuwei) in northwest China and then quantitatively evaluating the ecological risk from heavy metals by incorporating the uncertainty of health risk model parameters into the risk assessment. This study found that anthropogenic activities have influenced the accumulation of heavy metals in the study area and that the risk of contamination of soil heavy metals was characterized as light to moderate contamination and low ecological risk.

Assessing the sustainability of ecosystems over fourteen years of cultivation in Longnan City of China based on emergy analysis method.

Currently, the contradiction between the limited resources of China's cultivated ecosystems and population growth is becoming increasingly evident, and the negative impacts on the environment and human activities need to be curbed. Therefore, it is crucial to quantify the sustainability of cultivated ecosystems and determine these driving factors that affect their development. This study used the emergy method to quantify the input/output flow and sustainable development of the cultivated land ecosystem in Longnan City, combined with the logarithmic mean divisia index decomposition analysis (LMDI) method to evaluate the driving factors of sustainable development in the region.