A novel quantitative method for the determination of B-carrier boronophenylalanine in rat plasma by UHPLC-MS/MS and comparison with ICP-MS.

L-Boronophenylalanine (BPA), a widely used B carrier for clinical boron neutron capture therapy (BNCT), was quantified in rat plasma through a simple, effective and stable ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method. Chromatographic separation was performed on an ACQUITY UPLC HSS T3 (100 mm × 2.1 mm, 1.

Single-cell sequencing decodes the secrets of the RAP phenomenon of corticotomy.

Introduction: Corticotomy-assisted tooth movement is commonly performed in clinics, however, its time-limited efficacy and the fear of surgery among patients significantly limit its clinical application. Hence, researchers have investigated non-invasive methods to accelerate tooth movement. However, the molecular mechanisms underlying corticotomy-assisted tooth movement are not fully understood.

Identification and characterization of QSFS.sau-MC-5A for sterile florets genetically independent of fertile ones per spike in wheat.

A major and stable QTL for sterile florets per spike and sterile florets per spikelet was identified, it was mapped within a 2.22-Mb interval on chromosome 5AL, and the locus was validated using two segregating populations with different genetic backgrounds. Both the number of fertile florets per spike (FFS) and the number of sterile florets per spike (SFS) significantly influence the final yield of wheat (Triticum aestivum L.

Naringenin modulates the NO‑cGMP‑PKG signaling pathway by binding to AKT to enhance osteogenic differentiation in hPDLSCs.

Naringenin (NAR) is a prominent flavanone that has been recognized for its capacity to promote the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs). The present study aimed to explore how NAR promotes the osteogenic differentiation of hPDLSCs and to assess its efficacy in repairing alveolar bone defects. For this purpose, a protein‑protein interaction network of NAR action was established by mRNA sequencing and network pharmacological analysis.

{Mo}-directed structural evolution of highly reduced molybdenum red clusters for efficient proton conduction.

A series of highly reduced Mo red clusters {Mo} (1), {Mo} (2), and {Mo} (3) are synthesized from the rational assembly of planar {MoV4} building blocks and employed for proton conduction. 3 exhibits the best conductivity of 7.56 × 10 S cm under optimal conditions due to the most efficient hydrogen-bonding network.

CoCl-Induced hypoxia promotes hPDLSCs osteogenic differentiation through AKT/mTOR/4EBP-1/HIF-1α signaling and facilitates the repair of alveolar bone defects.

Bone defects are characterized by a hypoxic environment, which affects bone tissue repair. However, the role of hypoxia in the repair of alveolar bone defects remains unclear. Human periodontal ligament stem cells (hPDLSCs) are high-quality seed cells for repairing alveolar bone defects, whose behavior changes under hypoxia.

Brain potentials reveal how emotion filters native language access when bilinguals read words in their second language.

It is now well established that reading words in a second language (L2) automatically activates native language (L1) translations in bilinguals. Although there is evidence that access to such representations is inhibited when words have a negative emotional valence, the mechanism underlying such inhibition is elusive, and it is unknown whether inhibition arises online as L2 is being processed or whether negative valence affects subsequent L1 processing. Here, we recorded event-related brain potentials in Chinese-English bilinguals engaged in an implicit translation-priming paradigm involving L2 (English) word pairs.

Design, synthesis and mechanism study of novel natural-derived isoquinoline derivatives as antifungal agents.

In screening for natural fungicidal leads, two series of novel 3-aryl-isoquinoline derivatives 8 and 9 were designed and synthesized based on sanguinarine, chelerythrine and berberine. Their structures were confirmed by 1D, 2D NMR and HRMS. Most of the title compounds showed medium to excellent antifungal activity in vitro at 50 mg/L, which were much more active than the lead of sanguinarine.

Personality Counts More Than Appearance for Men Making Affective Judgments of Verbal Comments.

Previous research has shown that that evaluative verbal information (praise and criticism) conveys different affective values: criticism is perceived as unpleasant while praise is generally considered pleasant. Here, using praise and criticism in Chinese, we investigated how affective value is modulated in men and women, depending on the particular attribute (personality vs. appearance) targeted by social comments.

Utilization of washed MSWI fly ash as partial cement substitute with the addition of dithiocarbamic chelate.

The management of the big amount of fly ash as hazardous waste from the municipal solid waste incinerator (MSWI) has encountered many problems in China. In this study, a feasibility research on MSWI fly ash utilization as partial cement substitute in cement mortars was therefore carried out. MSWI fly ash was subjected to washing process to reduce its chlorine content (from 10.

[Distribution and characters of heavy metals from municipal solid waste incinerator fly ash].

The distribution and characters of heavy metals from municipal solid waste incinerator fly ash was studied in East China. The result indicate that heavy metals in fly ash were mainly distributed in fine particles. The heavy metals including Cd, Pb, Mg, and Cu could migrate easily from fly ash while Ag and Sn would be more stable.