Prediction of Disordered Linkers Using APOD.

Intrinsically disordered linkers (DLs) connect protein domains and structural elements within domains and facilitate allosteric regulation. Computational studies suggest that thousands of proteins have DLs. Since there are only about 250 proteins with manually curated DL annotations (DisProt database ver.

One-year outcomes of a novel venous stent for symptomatic iliofemoral venous obstruction: prospective cohort study.

Background: A stent with characteristics of a hybrid design may have advantages in improving the patency of symptomatic iliofemoral vein obstruction. This study assessed the safety and effectiveness of the V-Mixtent Venous Stent in treating symptomatic iliofemoral outflow obstruction.

Methods: Eligible patients had a Clinical-Etiologic-Anatomic-Physiologic (CEAP) C classification of ≥ 3 or a Venous Clinical Severity Score (VCSS) pain score of ≥ 2.

Efficacy of percutaneous mechanical thrombus removal in acute lower extremity deep venous thrombosis.

Background: Acute lower extremity deep venous thrombosis (LEDVT) is a common vascular emergency with significant morbidity risks, including post-thrombotic syndrome (PTS) and pulmonary embolism. Traditional treatments like catheter-directed thrombolysis (CDT) often result in variable success rates and complications.

Aim: To investigate the therapeutic efficacy of percutaneous mechanical thrombus removal in acute LEDVT.