Accumulated inflammation and fibrosis participate in atrazine induced ovary toxicity in mice.

Atrazine is a widely used herbicide in agricultural production. Previous studies have shown that atrazine affects hormone secretion and oocyte maturation in female reproduction. However, the specific mechanism by which atrazine affects ovarian function remains unclear.

HucMSC extracellular vesicles increasing SATB 1 to activate the Wnt/β-catenin pathway in 6-OHDA-induced Parkinson's disease model.

Parkinson's disease (PD) is a degenerative disorder of the nervous system characterized by the loss of dopaminergic neurons and damage of neurons in the substantia nigra (SN) and striatum, resulting in impaired motor functions. This study aims to investigate how extracellular vesicles (EVs) derived from human umbilical cord mesenchymal stem cells (HucMSC) regulate Special AT-rich sequence-binding protein-1 (SATB 1) and influence Wnt/β-catenin pathway and autophagy in PD model. The PD model was induced by damaging SH-SY5Y cells and mice using 6-OHDA.

Modeling of Burial History, Source Rock Maturity, and Hydrocarbon Generation of Marine-Continental Transitional Shale of the Permian Shanxi Formation, Southeastern Ordos Basin.

The Ordos Basin is characterized by abundant natural gas resources, and the marine-continental transitional shale gas of the Permian Shanxi Formation has great exploration and development potential. However, few systematic studies have focused on the burial history, thermal maturity, and hydrocarbon generation of the shale, which limits the understanding of shale gas enrichment and resource evaluation. To reveal the shale gas resource potential, we focused on the Shanxi Formation shale in the southeastern Ordos Basin.

Human neural stem cells promote mitochondrial genesis to alleviate neuronal damage in MPTP-induced cynomolgus monkey models.

Currently, there is no effective treatment for Parkinson's disease (PD), and the regenerative treatment of neural stem cells (NSCs) is considered the most promising method. This study aimed to investigate the protective effect and mechanism of NSCs on neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced cynomolgus monkey (Macaca fascicularis) model of PD. We first found that injecting NSCs into the subarachnoid space relieved motor dysfunction in PD cynomolgus monkeys, as well as reduced dopaminergic neuron loss and neuronal damage in the substantia nigra (SN) and striatum.

Rosmarinic acid mitigates acrylamide induced neurotoxicity via suppressing endoplasmic reticulum stress and inflammation in mouse hippocampus.

Background: Acrylamide (ACR) is a widely used compound that is known to be neurotoxic to both experimental animals and humans, causing nerve damage. The widespread presence of ACR in the environment and food means that the toxic risk to human health can no longer be ignored. Rosmarinic acid (RA), a natural polyphenolic compound extracted from the perilla plant, exhibits anti-inflammatory, antioxidant, and other properties.

Molecular Aggregation Strategy for Pore Generation in SiOC Ceramics Induced by the Conjugation Force of Phenyl.

Porous silicon oxycarbide (SiOC) ceramics with tailorable microstructure and porosity were fabricated using phenyl-substituted cyclosiloxane (C-Ph) as a molecular-scale porogen are analyzed in this study. A gelated precursor was synthesized via the hydrosilylation of hydrogenated and vinyl-functionalized cyclosiloxanes (CSOs), followed by pyrolysis at 800-1400 °C in flowing N gas. Tailored morphologies, such as closed-pore and particle-packing structures, with porosities in the range 20.

Ultrahigh Energy Efficiency and Large Discharge Energy Density in Flexible Dielectric Nanocomposites with PbLa(ZrSnTi)O Antiferroelectric Nanofillers.

Flexible dielectric capacitors have been widely studied recently on account of their fast charge-discharge speed, high power density, and superior wearable characteristics. Inorganic ferroelectric fillers/polymer matrix composites combining large maximum electric displacement () of ferroelectric materials with good flexibility and high electric breakdown strength () of the polymer are regarded as the most promising materials for preparing flexible dielectric capacitors with superior energy storage properties. However, simultaneously achieving large discharge energy density () and high energy efficiency (η) in these composites remains challenging on account of a large remnant electric displacement () and low - values of ferroelectric fillers.

Experimental Study of the Relationship Between Particle Size and Methane Sorption Capacity in Shale.

The amount of adsorbed shale gas is a key parameter used in shale gas resource evaluation and target area selection, and it is also an important standard for evaluating the mining value of shale gas. Currently, studies on the correlation between particle size and methane adsorption are controversial. In this study, an isothermal adsorption apparatus, the gravimetric sorption analyzer, is used to test the adsorption capacity of different particle sizes in shale to determine the relationship between the particle size and the adsorption capacity of shale.

Preparation of multi-layer nylon-6 nanofibrous membranes by electrospinning and hot pressing methods for dye filtration.

We report the formation of multi-layer nylon-6 (PA-6) nanofibrous membranes by electrostatic spinning coupled with a hot pressing process. The structure and porosity of multi-layer PA-6 nanofibrous membranes were characterized using a scanning electron microscope and the N nitrogen adsorption and desorption isotherms. We show that multi-layer PA-6 nanofibrous membranes can be used for efficient and continuous indigo dye filtration.

Design and simulation of betavoltaic battery using large-grain polysilicon.

In this paper, we present the design and simulation of a p-n junction betavoltaic battery based on large-grain polysilicon. By the Monte Carlo simulation, the average penetration depth were obtained, according to which the optimal depletion region width was designed. The carriers transport model of large-grain polysilicon is used to determine the diffusion length of minority carrier.