Injectable and adhesive MgO-potentiated hydrogel with sequential tumor synergistic therapy and osteogenesis for challenging postsurgical osteosarcoma treatment.

The clinical treatment of osteosarcoma faces great challenges of residual tumor cells leading to tumor recurrence and irregular bone defects difficult to repair after surgery removal of the primary tumor tissue. We developed an injectable and in-situ cross-linkable hydrogel (named MOG hydrogel) using MgO nanoparticles and dopamine-conjugated gelatin as main components. MgO was rationally designed as a multifunctional active ingredient to mediate in situ gelation, tumor therapy, and bone repair sequentially.

Rapid Detection of Total Petroleum Hydrocarbons in Soil Using Advanced Fluorescence Imaging Techniques.

Chemical methods for measuring soil organic content are often slow and yield inaccurate results due to significant errors. Simple summation of components may not accurately determine total organic content. In contrast, fluorescence imaging techniques offer rapid, in situ monitoring without complex pretreatment and demonstrate rapid and accurate assessment of soil organic content.

Plasmonic dielectric antennas for hybrid optical nanotweezing and optothermoelectric manipulation of single nanosized extracellular vesicles.

This paper showcases an experimental demonstration of near-field optical trapping and dynamic manipulation of an individual extracellular vesicle. This is accomplished through the utilization of a plasmonic dielectric nanoantenna designed to support an optical anapole state-a non-radiating optical state resulting from the destructive interference between electric and toroidal dipoles in the far-field, leading to robust near-field enhancement. To further enhance the field intensity associated with the optical anapole state, a plasmonic mirror is incorporated, thereby boosting trapping capabilities.

Propagation and control of congestion risk in scale-free networks based on information entropy.

To study the propagation pattern of congestion risk in the traffic network and enhance risk control capabilities, a model has been developed. This model takes into account the probabilities of five threats (the risk occurrence probability; the risk of loss; the unpredictability of risk; the uncontrollability of risk; the transferability of risk) in the traffic network to define the risk entropy and determine the risk capacity, analyze the mechanism of congestion risk propagation, and explore the impact of risk resistance, the average degree of risk capacity at intersections, and the degree of correlation on congestion risk propagation. Further, a control method model for risk propagation is proposed.

Multifunctional roles of inflammation and its causative factors in primary liver cancer: A literature review.

Primary liver cancer is a severe and complex disease, leading to 800000 global deaths annually. Emerging evidence suggests that inflammation is one of the critical factors in the development of hepatocellular carcinoma (HCC). Patients with viral hepatitis, alcoholic hepatitis, and steatohepatitis symptoms are at higher risk of developing HCC.

Reaction induced thermally stabilized TS-1 zeolite as a novel long-lasting catalyst for methyl lactate production.

Commercial TS-1 zeolite was functionalized as a stable catalyst for the one-pot transformation of fructose to methyl lactate (MLA) by the reaction solvent (methanol) to generate increased catalytic activity. As a result, TS-1 was recycled for 14 cycles without a regeneration process by calcination and accompanied by a surprising increased catalytic activity. This work is expected to provide a new option for the industrial production of biomass-based MLA by heterogeneous chemocatalysis.

Multidimensional conservation analysis decodes the expression of conserved long noncoding RNAs.

Although long noncoding RNAs (lncRNAs) experience weaker evolutionary constraints and exhibit lower sequence conservation than coding genes, they can still conserve their features in various aspects. Here, we used multiple approaches to systemically evaluate the conservation between human and mouse lncRNAs from various dimensions including sequences, promoter, global synteny, and local synteny, which led to the identification of 1,731 conserved lncRNAs with 427 high-confidence ones meeting multiple criteria. Conserved lncRNAs, compared with non-conserved ones, generally have longer gene bodies, more exons and transcripts, stronger connections with human diseases, and are more abundant and widespread across different tissues.

A 3D biomimetic optoelectronic scaffold repairs cranial defects.

Bone fractures and defects pose serious health-related issues on patients. For clinical therapeutics, synthetic scaffolds have been actively explored to promote critical-sized bone regeneration, and electrical stimulations are recognized as an effective auxiliary to facilitate the process. Here, we develop a three-dimensional (3D) biomimetic scaffold integrated with thin-film silicon (Si)-based microstructures.

Photobiomodulation therapy for management of inferior alveolar nerve injury post-extraction of impacted lower third molars.

Purpose: Inferior alveolar nerve (IAN) injury is one of the most serious complications after extraction of impacted lower third molars. Photobiomodulation (PBM) therapy has been noted to reduce pain and inflammation while promoting tissue healing. This study examined the efficacy of PBM therapy tested in a case series of patients with postoperative IAN injury.

Identification of spp in Tian Shan wapiti deer () in Xinjiang, China.

spp. are important zoonotic tick-borne pathogens that impact on human health. There are few reports on the prevalence and molecular genetic characteristics of Cervidae species in China.

Antimicrobial Activity of an Implantable Wireless Blue Light-Emitting Diode Against Root Canal Biofilm .

We developed an implantable wireless blue micro light-emitting diode (micro-LED) device and evaluated the utility of continuous antimicrobial blue light (aBL) irradiation emitted from this micro-LED for root canal disinfection. An implantable wireless blue micro-LED device (peak wavelength: 410 nm, maximum power: 15 mW) was developed to be placed in the root canal. Optical transmission of the device in human dentin tissue was simulated using Monte Carlo ray-tracing method.

Molecular characterization of Cryptosporidium spp. in minks (Neovison vison), blue foxes (Vulpes lagopus), and raccoon dogs (Nyctereutes procyonoides) in farms from Xinjiang, Northwest China.

The objective of this study was to determine the infection rate and genetic diversity of Cryptosporidium spp. in minks, foxes, and raccoon dogs, farmed in the Xinjiang Uygur Autonomous Region, Northwest China. Fresh fecal specimens were collected from individual cages of farmed minks (n = 214), blue foxes (n = 35), and raccoon dogs (n = 39) and examined using nested PCR based on the Cryptosporidium spp.

Molecular identification of Cryptosporidium spp. in pet snakes in Beijing, China.

Few reports of Cryptosporidium spp. in snakes in China have been published. To determine the infection rate and document the presence of Cryptosporidium in pet snakes using molecular methods, 273 fecal samples were collected from eight species of pet snakes from 13 pet households in Beijing, China, and were examined by PCR amplification of the small subunit ribosomal RNA gene.

First Report of Blastocystis Infection in Pigs from Large Farms in Xinjiang, China.

Blastocystis is a common intestinal protozoan in humans and various animals worldwide. A few studies have reported the genetic characterization of Blastocystis in pigs in China, but no epidemiological data are available from the Xinjiang Uygur Autonomous Region. In this study, 801 fecal samples were collected from seven scale pig farms in Xinjiang and tested by polymerase chain reaction and sequence analysis of the partial SSU rRNA gene.

A Landscape of Murine Long Non-Coding RNAs Reveals the Leading Transcriptome Alterations in Adipose Tissue during Aging.

Aging is an inevitable process that involves profound physiological changes. Long non-coding RNAs (lncRNAs) are emerging as important regulators in various biological processes but are not systemically studied in aging. To provide an organism-wide lncRNA landscape during aging, we conduct comprehensive RNA sequencing (RNA-seq) analyses across the mouse lifespan.

Molecular detection of Anaplasma spp. in dairy cattle in southern Xinjiang, China.

Bovine anaplasmosis is caused by a group of obligate intracellular bacteria belonging to the genus Anaplasma, which are transmitted by ticks. This study was conducted to determine the prevalences and molecular characterization of Anaplasma spp. in dairy cattle in the upper reaches of the Tarim River in Xinjiang, China.

Molecular identification and subtyping of Blastocystis sp. in laboratory rats in China.

Blastocystis sp. is a ubiquitous protist that has been frequently reported in humans and animals worldwide. A total of 355 fecal samples of experimental rats were collected from four laboratory rearing facilities in China, and Blastocystis sp.

Molecular identification and genotyping of Enterocytozoon bieneusi in experimental rats in China.

Experimental rats are important animal models, and a history of pathogenic infections in these animals will directly affect the animal trial results. Enterocytozoon bieneusi is a ubiquitous potential pathogen transmitted via the fecal-oral route. To determine the prevalence and genotypic distributions of E.

Genotyping and Zoonotic Potential of in Pigs in Xinjiang, China.

is an obligate intracellular fungus, infecting various invertebrate and vertebrate hosts, it is common in humans and causes diarrhea in the immunocompromised. In the present study, 801 fecal specimens were collected from pigs on seven large-scale pig farms in Xinjiang, China. Nested polymerase chain reaction (PCR) amplification of the internal transcribed spacer (ITS) gene showed that the overall i infection rate was 48.

Dual functional electrospun core-shell nanofibers for anti-infective guided bone regeneration membranes.

In clinic infection is the paramount cause for failure of guided bone regeneration (GBR) membranes. Therefore, it is crucial to develop anti-infective GBR membranes for clinical bone repair application. In this research, we successfully prepared electrospun core-shell nanofibers loaded with metronidazole (MNA) and nano-hydroxyapatites (nHA), which could be employed for anti-infective GBR membranes due to the achievement of dual functions with enhanced osteogenesis and slow MNA release.

Strontium ion attenuates lipopolysaccharide-stimulated proinflammatory cytokine expression and lipopolysaccharide-inhibited early osteogenic differentiation of human periodontal ligament cells.

Background And Objective: Periodontitis is a chronic inflammatory disease characterized by the destruction of the periodontium. The strontium ion (Sr ) can prevent the bone loss associated with periodontitis and promote the regeneration of the bone. The mechanisms by which the Sr works remain poorly understood.

Evaluation of thermal expansion coefficient of carbon fiber reinforced composites using electronic speckle interferometry.

An optical system for measuring the coefficient of thermal expansion (CTE) of materials has been developed based on electronic speckle interferometry. In this system, the temperature can be varied from -60°C to 180°C with a Peltier device. A specific specimen geometry and an optical arrangement based on the Michelson interferometer are proposed to measure the deformation along two orthogonal axes due to temperature changes.

DLX3 promotes bone marrow mesenchymal stem cell proliferation through H19/miR-675 axis.

The underlying molecular mechanism of the increased bone mass phenotype in Tricho-dento-osseous (TDO) syndrome remains largely unknown. Our previous study has shown that the TDO point mutation c.533A>G, Q178R in DLX3 could increase bone density in a TDO patient and transgenic mice partially through delaying senescence in bone marrow mesenchymal stem cells (BMSCs).