Novel Monomethoxy Poly(Ethylene Glycol) Modified Hydroxylated Tung Oil for Drug Delivery.

Novel monomethoxy poly(ethylene glycol) (PEG) modified hydroxylated tung oil (HTO), denoted as PEG-HTO-PEG, was designed and synthesized for drug delivery. PEG-HTO-PEG consists of a hydroxylated tung oil center joined by two PEG blocks via a urethane linkage. The properties of PEG-HTO-PEG were affected by the length of the mPEG chain.

Raman and FTIR spectroscopic studies on two hydroxylated tung oils (HTO) bearing conjugated double bonds.

Tung oil (TO) was used as a model compound to study two hydroxylated tung oils (HTO), prepared from TO by either aminolysis (HTO-am) or alcoholysis (HTO-al). Main bands in Raman and FTIR spectra were initially assigned based on the detailed analysis of the compound spectra before and after exposure to elevated temperature (200°C). The effect of heat treatment in air on spectral bands, and especially on the changes associated with double bonds, were then investigated.

Sulfated modification promotes the immunomodulatory bioactivities of Lyciumbarbarum polysaccharides in vitro.

Three kinds of purified Lyciumbarbarum polysaccharides (LBPSs), LBPS30, LBPS70 and total LBPS (LBPSt), were modified using chlorosulfonic acid-pyridine method based on the previous experiment, forming three sulfated LBPS (sLBPS), sLBPSt, sLBPS30 and sLBPS70 respectively. They were characterized by ultrasonic-acidic barium chromate spectrophotometry, infrared (FT-IR) and high performance gel permeation chromatography (HPGPC). The immunomodulatory activity of each kind of LBPSs and sLBPSs was further examined to determine the relationship between the structure and bioactivity, and the sLBPS with the highest activity was selected.