Targeting both death and paracaspase domains of MALT1 with antisense oligonucleotides overcomes resistance to immune-checkpoint inhibitors.

Targeting MALT1's paracaspase activity has been explored for B cell lymphoma and solid tumors. While the role of MALT1 in promoting cancer cell proliferation has been investigated, its involvement in immune evasion is unclear. Here we report that MALT1 promotes immune evasion through its paracaspase and death domain.

OPG promotes lung metastasis by reducing CXCL10 production of monocyte-derived macrophages and decreasing NK cell recruitment.

Background: Lung metastasis is a critical and often fatal progression in cancer patients, with monocyte-derived macrophages (Mo-macs) playing multifaceted roles in this process. Despite the recognized importance of Mac-macs, most studies focus on these cells themselves, while the precise mechanisms through which tumor cells manipulate Mo-macs to promote metastasis remain poorly understood.

Methods: We developed an in vivo CRISPR screening system to identify genes involved in macrophage-dependent metastasis by depleting Mo-macs.

Lymphotoxin-β promotes breast cancer bone metastasis colonization and osteolytic outgrowth.

Bone metastasis is a lethal consequence of breast cancer. Here we used single-cell transcriptomics to investigate the molecular mechanisms underlying bone metastasis colonization-the rate-limiting step in the metastatic cascade. We identified that lymphotoxin-β (LTβ) is highly expressed in tumour cells within the bone microenvironment and this expression is associated with poor bone metastasis-free survival.

Driving forces and recovery potential of the macrophyte decline in East Taihu Lake.

Macrophytes are of key importance to the structure and ecological services of shallow lakes and are sensitive to anthropogenic and natural perturbations. Ongoing eutrophication and hydrological regime change affect macrophytes through changes in water transparency and water level, which lead to a dramatic decrease in bottom light availability. Here an integrated dataset (2005-2021) of multiple environmental factors is used to demonstrate the driving forces and recovery potential of the macrophyte decline in East Taihu Lake by using a critical indicator, which is the ratio of the Secchi disk depth to the water depth (SD/WD).

CeO supported MOFs derived LaBFeO (B=Mn, Co) perovskite catalysts for degradation of toluene.

In this work, LaCoO and LaMnO perovskites with the higher specific surface area were synthesized using MOFs as precursor, then, the composite catalysts CeO-LaCoFeO and CeO-LaMnFeO were prepared by using CeO as support and Fe element doping LaCoO and LaMnO, respectively. The as-prepared samples were characterized by XRD, SEM, XPS, H-TPR, and N physisorption techniques. Subsequently, toluene was used as the probe molecule for volatile organic compounds (VOCs) to test the catalytic activity of these as-prepared catalysts.

Effect of A, B-site cation on the catalytic activity of LaAMnBO (A = Ce, B = Ni) perovskite-type oxides for toluene oxidation.

ABO-type perovskites (A = La, Ce; B = Mn, Ni) were prepared by sol-gel method, and applied for catalytic oxidation of toluene. The activity test results show that the activity of LaMnO can be improved when a small amount of Ce and Ni are doped into the A and B sites of LaMnO, respectively. The effects of different calcination temperatures and different calcination time on the preparation of La-based perovskites were also investigated.

Influence of the impoundment of the Three Gorges Reservoir on hydrothermal conditions for fish habitat in the Yangtze River.

The thermal regimes of rivers play an important role in the overall health of aquatic ecosystems. Modifications to water temperature regimes resulting from dams and reservoirs have important consequences for river ecosystems. This study investigates the impacts of the impoundment of the Three Gorges Reservoir (TGR) on the water temperature regime of fish spawning habitats in the middle reach of the Yangtze River, China.

Tumor-derived Jagged1 promotes cancer progression through immune evasion.

Immune checkpoint inhibitor (ICI) therapy is generating remarkable responses in individuals with cancer, but only a small portion of individuals with breast cancer respond well. Here we report that tumor-derived Jagged1 is a key regulator of the tumor immune microenvironment. Jagged1 promotes tumorigenesis in multiple spontaneous mammary tumor models.

Anti-inflammatory and antibacterial activities of Pyrrosia petiolosa ethyl acetate (PPEAE) against Staphylococcus aureus in mice.

P. petiolosa as a typical Chinese herbal medicine has been generally utilized as Chinese native medicine formulation for treatment of chronic bronchitis, bronchial asthma and pneumoconiosis. The objective of this study was to evaluate the anti-inflammatory and antibacterial activities of P.

Anti-inflammatory and antibacterial activities of P. petiolosa (Christ) Ching ethyl acetate extract against S. aureus in mice.

P. petiolosa as a typical Chinese herbal medicine has been generally utilized as Chinese native medicine formulation for treatment of chronic bronchitis, bronchial asthma and pneumoconiosis. The objective of this study was to evaluate the anti-inflammatory and antibacterial activities of P.

A novel high-performance CeO-CuMnO catalyst for toluene degradation.

A series of spinel CuMO (M = Mn, Fe, and Al) was used as the catalyst to investigate the effective degradation of toluene, and then CuMnO with better catalytic activity was selected as the research object to study its activity at different ratios of Cu and Mn. Meanwhile, CeO was introduced to modify CuMn bimetallic oxide to improve its catalytic performance. The structure, morphology, and valence states of surface elements of as-prepared catalysts were characterized by XRD, TEM, SEM, N adsorption-desorption, XPS, and H-TPR.

Water temperature forecasting based on modified artificial neural network methods: Two cases of the Yangtze River.

Water temperature is a controlling indicator of river habitat since many physical, chemical and biological processes in rivers are temperature dependent. Highly precise and reliable predictions of water temperature are important for river ecological management. In this study, a hybrid model named BP_PSO3, based on the BPNN (back propagation neural network) optimized by the PSO (particle swarm optimization) algorithm, is proposed for water temperature prediction using air temperature (Ta), discharge (Q) and day of year (DOY) as input variables.

Improved comprehensive ecological risk assessment method and sensitivity analysis of polycyclic aromatic hydrocarbons (PAHs).

Based on the existing comprehensive ecological risk assessment methods of PAHs, this paper proposed an improved hierarchical Archimedean copula integral assessment (HACIA) model with the optimization in the model selection mechanism and accelerating the calculation speed, and according to which performed the sensitivity analysis of the integrated risk relative to the underlying grouped risk probability. Taihu Lake in China and the Bay of Santander in Spain were taken as study areas, whose samples were obtained and extracted concentrations of 16 priority polycyclic aromatic hydrocarbons (PAHs). After briefly analyzing their concentration characteristics and source, their comprehensive ecological risks were evaluated by the improve HACIA model and their sensitivity was also analyzed.

Vine copula selection using mutual information for hydrological dependence modeling.

Hydrological risk analysis and management entails multivariate modeling which requires modeling the structure of dependence among different variables. Vine copulas have been increasing applied in multivariate modeling wherein the selection of vine copula structure plays a critical role. Inspired by the relationship between Mutual information (MI) and copula entropy (CE), this study discussed the connection between conditional mutual information (CMI) and CE and developed a mutual information-based sequential approach to select a vine structure which was based on original observations, and model-independent.

A probabilistic modeling framework for assessing the impacts of large reservoirs on river thermal regimes - A case of the Yangtze River.

Hydrological and thermal river regimes have changed greatly due to the construction of reservoirs and dams. Water temperature changes have important significance for aquatic habitats and freshwater ecosystems. To investigate the impact of large reservoirs on the water temperature regime along the middle reach of the Yangtze River, we present a probabilistic modeling framework to ascertain the joint dependence structures of air-water temperature and discharge-water temperature between pre-reservoir and post-reservoir periods based on the copula theory.

Direct Z-scheme LaCeMnO catalyst for photothermal degradation of toluene.

A series of Ce-doped LaMnO (LaCeMnO) were prepared and were tested for gaseous toluene oxidation in order to investigate the effect of cerium doping in LaMnO on activity under photothermal conditions. It was found that the activity and CO yield of the catalyst can be effectively increased when x = 0.25.

Quantifying the change in streamflow complexity in the Yangtze River.

Hydrological processes of the Yangtze River have changed over the past decades due to environmental change and human activity. This paper uses sample entropy to investigate the spatial distribution and dynamic change in streamflow series complexity in the Yangtze River, China. In this study, the complexity of the streamflow series is quantified by entropy analysis.

Effects of the RNA-binding protein, KSRP, on innate immune response against Helicobacter pylori infection in mice.

Helicobacter pylori (H. pylori) contributes to various gastric diseases such as chronic gastritis, gastric ulcer, and gastric carcinoma. Host innate immune response against the pathogen plays a significant role in elimination of pathogen infection.