Publications by authors named "Yuwei Kou"
Multidrug combination therapy in the inner ear faces diverse challenges due to the distinct physicochemical properties of drugs and the difficulties of overcoming the oto-biologic barrier. Although nanomedicine platforms offer potential solutions to multidrug delivery, the access of drugs to the inner ear remains limited. Micro/nanomachines, capable of delivering cargo actively, are promising tools for overcoming bio-barriers.
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- Hearing loss is primarily caused by damage to outer hair cells in the cochlea, and local drug delivery through the round window membrane shows promise but faces challenges in effectively reaching certain cochlear regions.
- Researchers developed poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) modified with a targeting peptide (A665) that binds to prestin, improving drug uptake in all cochlear turns.
- The study demonstrated that curcumin-loaded A665-PLGA NPs significantly protected outer hair cells in treated guinea pigs compared to standard PLGA NPs, showing great potential for targeted therapy in treating severe hearing loss.