Spatiotemporal Variation Assessment and Improved Prediction Of Cyanobacteria Blooms in Lakes Using Improved Machine Learning Model Based on Multivariate Data.

Cyanobacterial blooms in shallow lakes pose a significant threat to aquatic ecosystems and public health worldwide, highlighting the urgent need for advanced predictive methodologies. As impounded lakes along the Eastern Route of the South-to-North Water Diversion Project, Lakes Hongze and Luoma play a key role in water resource management, making the prediction of cyanobacterial blooms in these lakes particularly important. To address this, satellite remote sensing data were utilized to analyze the spatiotemporal dynamics of cyanobacterial blooms in these lakes.

Gene‒Environment Interaction Between CAST Gene and Eye-Rubbing in the Chinese Keratoconus Cohort Study: A Case-Only Study.

Purpose: Keratoconus (KC), characterized by progressive corneal protrusion and thinning, is a complex disease influenced by the combination of genetic and environmental factors. The purpose of this study was to explore potential gene‒environment interaction between the calpastatin (CAST) gene and eye-rubbing in KC.

Methods: A case-only study including 930 patients (676 patients with eye-rubbing and 254 patients without eye-rubbing) from the Chinese Keratoconus (CKC) cohort study was performed in the present study.

Integrated gold nanorods-based dual-signal platform for accurate total antioxidant capacity assessment in food samples.

Accurate assessment of Total Antioxidant Capacity (TAC) in food is crucial for evaluating nutritional quality and potential health benefits. This study aims to enhance the sensitivity and reliability of TAC detection through a dual-signal method, combining colorimetric and photothermal signals. Gold nanorods (AuNRs) were utilized to establish a dual-signal method duo to the colorimetric and photothermal properties.

Controlled and orthogonal partitioning of large particles into biomolecular condensates.

Biomolecular condensates arising from liquid-liquid phase separation contribute to diverse cellular processes, such as gene expression. Partitioning of client molecules into condensates is critical to regulating the composition and function of condensates. Previous studies suggest that client size limits partitioning, with dextrans >5 nm excluded from condensates.

Association of Novel Loci With Keratoconus Susceptibility in a Chinese Genome-Wide Association Study.

Purpose: Keratoconus (KC) is a progressive corneal disease that can lead to corneal blindness if not properly managed. The purpose of this study was to identify genetic associations with KC in China and to investigate whether these genetic variants are associated with corneal thickness and corneal curvature in KC cases.

Methods: A genome-wide association study was conducted on 853 patients with KC and 6248 controls.

The Chinese keratoconus (CKC) cohort study.

The Chinese keratoconus (CKC) cohort study is a population-based longitudinal prospective cohort study in the Chinese population involving a clinical database and biobanks. This ongoing study focuses on the prevention of KC progression and is the first to involve the effect of gene‒environment interactions on KC progression. The CKC cohort is hospital-based and dynamic and was established in Zhengzhou, China; KC patients (n = 1114) from a large geographical area were enrolled from January 2019 to June 2023, with a mean age of 22.

Electrochemical coalescence of oil-in-water droplets in microchannels of TiO/Ti anode via polarization eliminating electrostatic repulsion and ·OH oxidation destroying oil-water interface film.

Electrochemistry is a sustainable technology for oil-water separation. In the common flat electrode scheme, due to a few centimeters away from the anode, oil droplets have to undergo electromigration to and electrical neutralization at the anodic surface before they coalesce into large oil droplets and rise to water surface, resulting in slow demulsification and easy anode fouling. Herein, a novel strategy is proposed on basis of a TiO/Ti anode with microchannels to overcome these problems.

Machine learning analysis with the comprehensive index of corneal tomographic and biomechanical parameters in detecting pediatric subclinical keratoconus.

Keratoconus (KC) occurs at puberty but diagnosis is focused on adults. The early diagnosis of pediatric KC can prevent its progression and improve the quality of life of patients. This study aimed to evaluate the ability of corneal tomographic and biomechanical variables through machine learning analysis to detect subclinical keratoconus (SKC) in a pediatric population.

A high body mass index strengthens the association between the time of eye rubbing and keratoconus in a Chinese population: a case control study.

Background: Although body mass index (BMI) and eye rubbing are linked to an increased risk of keratoconus (KC), the interactive effect of eye rubbing and BMI on KC is largely unknown. This study aimed to evaluate the independent and interactive effects of BMI and eye rubbing on KC and to further explore the role of environmental factors on the occurrence of KC.

Methods: A total of 621 individuals (291 KC patients and 330 control individuals) were enrolled in this hospital‑based study on KC patients in Central China after individuals missing BMI data were excluded.

CircularRNA Hsa_circ_0093335 promotes hepatocellular carcinoma progression via sponging miR-338-5p.

Circular RNAs play an important role in the development of various malignancies, including hepatocellular carcinoma (HCC). Nevertheless, the role of Hsa_circ_0093335 (circ0093335) in HCC has not yet been explored. To investigate the biological effects and molecular mechanisms of circ0093335 on HCC.

Accuracy of tomographic and biomechanical parameters in detecting unilateral post-LASIK keratoectasia and fellow eyes.

Patients with unilateral post-LASIK keratectasia (KE) have clinical ectasia in one eye but not in the fellow eye. As serious complications, these cases are rarely reported but are worth investigating. This study aimed to explore the characteristics of unilateral KE and the accuracy of corneal tomographic and biomechanical parameters to detect KE and distinguish fellow eyes from control eyes.

Facilitated OH¯ diffusion via bubble motion and water flow in a novel electrochemical reactor for enhancing homogeneous nucleation of CaCO.

Electrochemistry is a potential method for water softening. An essential disadvantage is OH¯ ions from water electrolysis accumulate on cathode surface, inducing the generation of the insulating CaCO layer and then interrupting the electrochemical reaction. In order to propel OH¯ diffusion into the bulk solution instead of aggregation at cathode, we designed an electrochemical reactor, whose electrodes were placed horizontally in the middle of the reactor, and the bubbles created by water electrolysis move upward, while the water flows downward.

Portable smartphone-assisted ratiometric fluorescence sensor for visual detection of glucose.

Fluorescence-based visual assays have sparked tremendous attention in on-site detection due to their obvious color gradient changes and high sensitivity. In this study, a novel emission wavelength shift-based visual sensing platform is constructed to detect glucose based on the oxidation of Rhodamine B (RhB). MnO nanosheets (MnO NS) with strong oxidizing properties were introduced to oxidize RhB, which resulted in a blue shift in the emission wavelength, and a visual color changed of the fluorescence from orange-red to green.

Bioinformatics analysis of key candidate genes and pathways in Chinese patients with keratoconus.

Keratoconus (KC) is a multifactorial disease in which genetic factors played important roles in its pathogenesis. The purpose of the current study was to identify the key candidate genes and pathways in Chinese patients with KC through bioinformatics analysis. Totally, we identified 71 candidate genes by analyzing the results of whole exome sequencing on 51 Chinese patients with KC, combining with previous reports on differential expression at transcription and protein levels in KC.

A novel technique to quantify bone-to-implant contact of zygomatic implants: a radiographic analysis based on three-dimensional image registration and segmentation.

Objectives: The purpose of this study is to establish a novel, reproducible technique to obtain the BIC area (BICA) between zygomatic implants and zygomatic bone based on post-operative cone-beam computed tomography (CBCT) images. Three-dimensional (3D) image registration and segmentation were used to eliminate the effect of metal-induced artifacts of zygomatic implants.

Methods: An ex-vivo study was included to verify the feasibility of the new method.

Trio-based exome sequencing broaden the genetic spectrum in keratoconus.

Keratoconus (KC) is a complex corneal disorder with genetic factors involving in its pathogenesis. The genetic etiology of KC has not been fully elucidated. In this study, we aimed to expand the genetic spectrum in KC by trio-based exome sequencing.

Family-based exome sequencing identifies candidate genes related to keratoconus in Chinese families.

Keratoconus (KC) is a complex corneal disorder with a strong genetic component. The present study aimed to identify candidate genes related to KC in Chinese families. Family-based exome sequencing was performed in ten patients suffering from KC who belong to five families with two affected members in each.

Bacterial Keratitis Following Small Incision Lenticule Extraction.

Purpose: To describe the development of bacterial keratitis after small incision lenticule extraction in 5 patients and to explore its appropriate therapies.

Methods: We retrospectively summarized the clinical treatments of five patients with postoperative bacterial infection after small incision lenticule extraction, who were referred to our hospital from 2019 to 2021.

Results: Five male patients had undergone bilateral SMILE in the local hospital due to myopia aged from 18 to 26 years.

Distribution of pediatric keratoconus by different age and gender groups.

Purpose: To evaluate the distribution of pediatric keratoconus patients and the disease severity based on different age and gender groups in China.

Materials And Methods: A total of 446 keratoconus eyes in 266 pediatric patients from January 2019 to January 2022 were included in the cross-sectional study. The clinical findings and severity of keratoconus were recorded and Kruskal-Wallis test, chi-squared test, and Cochran-Mantel-Haenszel (CMH) test were used to compare the parameters between different gender and age groups.

Heritability of Corneal Parameters in Nuclear Families With Keratoconus.

Purpose: This study aimed to investigate the heritability of corneal parameters obtained by Pentacam in nuclear families with keratoconus (KC).

Methods: A total of 82 patients with KC and their biological parents (n = 164) were recruited in the current study. All subjects underwent corneal tomography with Pentacam.

A Bibliometric Analysis of 100 Most-Cited Articles on Corneal Cross-Linking.

Background: Highly cited papers are expected to have high-quality data that significantly contribute to the body of knowledge. The study aimed to evaluate the characters of the 100 most-cited articles on corneal cross-linking (CXL) through a bibliometric analysis.

Materials And Methods: The Web of Science database was searched to identify papers published from 1950 to 2020.

A Hospital-Based Study on the Prevalence of Keratoconus in First-Degree Relatives of Patients with Keratoconus in Central China.

Purpose: The present study investigated the prevalence of keratoconus (KC) among first-degree relatives of KC patients in Central China.

Methods: From July 2018 to March 2022, 661 first-degree relatives of 384 KC patients were included in the present study. Corneal tomography, uncorrected distance visual acuity, manifest refraction with corrected distance visual acuity, intraocular pressure, slit-lamp microscopy, and fundus examination were performed.

A bibliometric analysis of the top 100 most-cited articles on keratoconus.

Purpose: To explore the characteristics of the top 100 most-cited articles on keratoconus research.

Methods: The Web of Science database was searched to identify papers published from 1950 to 2020. A bibliometric analysis of the top 100 most-cited articles was conducted in the current study.