Publications by authors named "Yuuki Wazawa"
Cell Signal
September 2023
Article Synopsis
- c-Src tyrosine kinase is involved in various signaling pathways and is often overactive in many cancers, while v-Src, its oncogenic form, leads to disruptions in cell division, specifically cytokinesis.
- The study investigates how v-Src causes Aurora B protein, which is crucial for proper cell division, to mislocalize during monopolar cytokinesis.
- Findings reveal that v-Src reduces Aurora B's autophosphorylation and kinase activity, leading to its delocalization, suggesting v-Src indirectly inhibits Aurora B's function rather than directly modifying it.
