Publications by authors named "Yuuichi Nagase"
J Bone Miner Res
December 2012
Article Synopsis
- Class IA PI3Ks are crucial for osteoclast function, activated by growth factors like α(v) β(3) integrin and c-Fms, which influence bone resorption.
- The deletion of p85 genes in osteoclasts leads to an osteopetrotic phenotype due to impaired bone-resorbing activity and defects in necessary cellular processes.
- This study highlights the importance of the class IA PI3K-Akt pathway in osteoclast activity and suggests potential therapeutic targets for treating bone diseases.
